Dear Editor. Parkinson＇s disease （PD） is the second most prevalent neurodegenerative disorder affecting about 1% of the worldwide population over the age of 60 （EI-Agnaf, 2003; Majbour, Vaikath et al, 2016）. Moto...Dear Editor. Parkinson＇s disease （PD） is the second most prevalent neurodegenerative disorder affecting about 1% of the worldwide population over the age of 60 （EI-Agnaf, 2003; Majbour, Vaikath et al, 2016）. Motor symptoms, which is currently the major trait for PD diagnosis, appear when 50%-60% of dopaminergic neurons in the substantia nigra （SN） and 70%-80% of dopaminergic terminals in the striatum are lost （Kim, Paik et al., 2014; Landeck, Hall et al.,展开更多
A concise synthesis of the mosquito oviposition attractant pheromone, (-)-(5R, 6S)- and (+)-(5S 6R)-6-acetoxy hexadecanolide from L-glutamic acid is described. The key steps are the inversion of the configuration at C...A concise synthesis of the mosquito oviposition attractant pheromone, (-)-(5R, 6S)- and (+)-(5S 6R)-6-acetoxy hexadecanolide from L-glutamic acid is described. The key steps are the inversion of the configuration at C-4 of 7, and the formation of δ-lactone from the γ-lactone through ring enlargement.展开更多
文摘Dear Editor. Parkinson＇s disease （PD） is the second most prevalent neurodegenerative disorder affecting about 1% of the worldwide population over the age of 60 （EI-Agnaf, 2003; Majbour, Vaikath et al, 2016）. Motor symptoms, which is currently the major trait for PD diagnosis, appear when 50%-60% of dopaminergic neurons in the substantia nigra （SN） and 70%-80% of dopaminergic terminals in the striatum are lost （Kim, Paik et al., 2014; Landeck, Hall et al.,
文摘A concise synthesis of the mosquito oviposition attractant pheromone, (-)-(5R, 6S)- and (+)-(5S 6R)-6-acetoxy hexadecanolide from L-glutamic acid is described. The key steps are the inversion of the configuration at C-4 of 7, and the formation of δ-lactone from the γ-lactone through ring enlargement.
