Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in undergroun...Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.展开更多
针对传统点积注意力缺乏方向性的问题,建立了一种基于余弦相似性的定向注意力模型(directed attention model,DAM)。为有效表示视频帧时空特征间的方向关系,运用余弦相似性理论,定义了注意力机制中关系函数,能够去除特征间关系绝对值;...针对传统点积注意力缺乏方向性的问题,建立了一种基于余弦相似性的定向注意力模型(directed attention model,DAM)。为有效表示视频帧时空特征间的方向关系,运用余弦相似性理论,定义了注意力机制中关系函数,能够去除特征间关系绝对值;为降低注意力机制计算量,从时间和空间两个维度上对运算进行分解;结合线性注意力运算,进一步优化计算复杂度。实验分为两个阶段:对定向注意力各模块开展了4个消融实验,以表现DAM在精确度和效率方面的最佳性能;该模型在Sth-Sth V1(somethingsomething V1)数据集上的精确度较I3D-NL(inflated 3D ConvNet non-local)高7.3%,在UCF101(101 human action classes from videos in the wild)数据集上的识别精确率为95.7%。研究成果在安全监控、自动驾驶等方面应用前景广泛。展开更多
Crohn’s disease(CD)is caused by immune,environmental,and genetic factors.It can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains unclear.Emerging biolog...Crohn’s disease(CD)is caused by immune,environmental,and genetic factors.It can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains unclear.Emerging biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known drugs.To achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost urgency.In this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary data.The supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid metabolism.Another benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic dysfunction.More importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.展开更多
Colorectal cancer liver metastasis(CRLM)presents a clinical challenge,and optimizing treatment strategies is crucial for improving patient outcomes.Surgical resection,a key element in achieving prolonged survival,is o...Colorectal cancer liver metastasis(CRLM)presents a clinical challenge,and optimizing treatment strategies is crucial for improving patient outcomes.Surgical resection,a key element in achieving prolonged survival,is often linked to a heightened risk of recurrence.Acknowledging the potential benefits of preoperative neoadjuvant chemotherapy in managing resectable liver metastases,this approach has gained attention for its role in tumor downsizing,assessing biological behavior,and reducing the risk of postoperative recurrence.However,the use of neoadjuvant chemotherapy in initially resectable CRLM sparks ongoing debates.The balance between tumor reduction and the risk of hepatic injury,coupled with concerns about delaying surgery,necessitates a nuanced approach.This article explores recent research insights and draws upon the practical experiences at our center to address critical issues regarding considerations for initially resectable cases.Examining the criteria for patient selection and the judicious choice of neoadjuvant regimens are pivotal areas of discussion.Striking the right balance between maximizing treatment efficacy and minimizing adverse effects is imperative.The dynamic landscape of precision medicine is also reflected in the evolving role of gene testing,such as RAS/BRAF and PIK3CA,in tailoring neoadjuvant regimens.Furthermore,the review emphasizes the need for a multidisciplinary approach to navigate the comp-lexities of CRLM.Integrating technical expertise and biological insights is crucial in refining neoadjuvant strategies.The management of progression following neoadjuvant chemotherapy requires a tailored approach,acknowledging the diverse biological behaviors that may emerge.In conclusion,this review aims to provide a comprehensive perspective on the considerations,challenges,and advancements in the use of neoadjuvant chemotherapy for initially resectable CRLM.By combining evidencebased insights with practical experiences,we aspire to contribute to the ongoing discourse on refining treatment paradigms for improved outcomes in patients with CRLM.展开更多
荔枝是华南地区最具特色的水果之一,目前我国荔枝栽培面积约53万hm^(2),产量230万t。荔枝花序呈聚伞花序圆锥状排列,分枝数量过多会消耗树体大量营养,影响荔枝坐果。SUPPRESSOR OF MAX21-LIKE 7(SMXL7)是独脚金内酯信号途径的重要组分,...荔枝是华南地区最具特色的水果之一,目前我国荔枝栽培面积约53万hm^(2),产量230万t。荔枝花序呈聚伞花序圆锥状排列,分枝数量过多会消耗树体大量营养,影响荔枝坐果。SUPPRESSOR OF MAX21-LIKE 7(SMXL7)是独脚金内酯信号途径的重要组分,是具有抑制子和转录因子双重功能的新型抑制子,参与调控植物的分枝发育。为了鉴定荔枝花穗分枝发育的调控基因,本研究以‘妃子笑/怀枝’砧穗组合荔枝结果树花穗为试材,利用RNA-seq数据克隆荔枝SMXL7基因家族成员LcSMXL7,并对其基因序列、理化性质、保守结构域、进化关系、组织表达特异性,基因功能及亚细胞定位进行分析。分析结果显示,该基因ORF全长3408 bp,编码1135个氨基酸;编码蛋白含有2个Clp结构域和1个AAA_2结构域;在茎、种子和叶片中表达较高,在花穗、雄花和果皮中表达次之,而在雌花、果肉和根中的表达最低;LcSMXL7的分子式为C_(5429)H_(8632)N_(1530)O_(1715)S_(38),理论相对分子质量(Mw)为123.99 kDa,理论等电点(pI)约为5.96,蛋白脂溶指数为83.74,蛋白不稳定指数为46.38,亲水性平均系数为-0.305,与来自木本果树甜橙和杧果的SMXL7蛋白的关系较近,亚细胞定位在细胞核;在拟南芥中过表达LcSMXL7可显著提高拟南芥的分枝数量。推测LcSMXL7可作为转录因子参与基因表达调控,该研究为进一步探索LcSMXL7调控荔枝花穗发育的分子机制奠定了基础。展开更多
基金supported by National Key R&D Program of China(No.2022YFC3004705)the National Natural Science Foundation of China(Nos.52074280,52227901 and 52204249)National Natural Science Foundation of China Youth Fund(No.52104230).
文摘Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.
文摘针对传统点积注意力缺乏方向性的问题,建立了一种基于余弦相似性的定向注意力模型(directed attention model,DAM)。为有效表示视频帧时空特征间的方向关系,运用余弦相似性理论,定义了注意力机制中关系函数,能够去除特征间关系绝对值;为降低注意力机制计算量,从时间和空间两个维度上对运算进行分解;结合线性注意力运算,进一步优化计算复杂度。实验分为两个阶段:对定向注意力各模块开展了4个消融实验,以表现DAM在精确度和效率方面的最佳性能;该模型在Sth-Sth V1(somethingsomething V1)数据集上的精确度较I3D-NL(inflated 3D ConvNet non-local)高7.3%,在UCF101(101 human action classes from videos in the wild)数据集上的识别精确率为95.7%。研究成果在安全监控、自动驾驶等方面应用前景广泛。
文摘Crohn’s disease(CD)is caused by immune,environmental,and genetic factors.It can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains unclear.Emerging biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known drugs.To achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost urgency.In this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary data.The supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid metabolism.Another benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic dysfunction.More importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.
文摘Colorectal cancer liver metastasis(CRLM)presents a clinical challenge,and optimizing treatment strategies is crucial for improving patient outcomes.Surgical resection,a key element in achieving prolonged survival,is often linked to a heightened risk of recurrence.Acknowledging the potential benefits of preoperative neoadjuvant chemotherapy in managing resectable liver metastases,this approach has gained attention for its role in tumor downsizing,assessing biological behavior,and reducing the risk of postoperative recurrence.However,the use of neoadjuvant chemotherapy in initially resectable CRLM sparks ongoing debates.The balance between tumor reduction and the risk of hepatic injury,coupled with concerns about delaying surgery,necessitates a nuanced approach.This article explores recent research insights and draws upon the practical experiences at our center to address critical issues regarding considerations for initially resectable cases.Examining the criteria for patient selection and the judicious choice of neoadjuvant regimens are pivotal areas of discussion.Striking the right balance between maximizing treatment efficacy and minimizing adverse effects is imperative.The dynamic landscape of precision medicine is also reflected in the evolving role of gene testing,such as RAS/BRAF and PIK3CA,in tailoring neoadjuvant regimens.Furthermore,the review emphasizes the need for a multidisciplinary approach to navigate the comp-lexities of CRLM.Integrating technical expertise and biological insights is crucial in refining neoadjuvant strategies.The management of progression following neoadjuvant chemotherapy requires a tailored approach,acknowledging the diverse biological behaviors that may emerge.In conclusion,this review aims to provide a comprehensive perspective on the considerations,challenges,and advancements in the use of neoadjuvant chemotherapy for initially resectable CRLM.By combining evidencebased insights with practical experiences,we aspire to contribute to the ongoing discourse on refining treatment paradigms for improved outcomes in patients with CRLM.
