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桥梁桩基废弃泥浆制作地聚物胶凝材料试验研究
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作者 游彪 邬俊峰 +1 位作者 董金中 胡国祥 《建材技术与应用》 2024年第4期58-61,共4页
为处理桥梁桩基废弃泥浆,采用工业固废协同泥浆制作地质聚合物胶凝材料,改良其工程性能。基于正交试验设计原理,参考水泥胶砂试验方法研究了泥浆掺量、水固比、养护龄期对地聚物胶凝材料强度的影响。试验结果表明:掺加泥浆的地聚物胶凝... 为处理桥梁桩基废弃泥浆,采用工业固废协同泥浆制作地质聚合物胶凝材料,改良其工程性能。基于正交试验设计原理,参考水泥胶砂试验方法研究了泥浆掺量、水固比、养护龄期对地聚物胶凝材料强度的影响。试验结果表明:掺加泥浆的地聚物胶凝材料28 d抗压强度可达21.65 MPa,抗折强度可达4.11 MPa。在泥浆掺量为30%~50%、水固比为0.35~0.55及养护龄期28 d范围内,地聚物胶凝材料的抗压、抗折强度与泥浆掺量、水固比呈负相关,与养护龄期呈正相关。 展开更多
关键词 桥梁桩基 废弃泥浆 地聚物胶凝材料 粉煤灰 矿渣粉 脱硫石膏
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老年非小细胞肺癌患者和肠道产丁酸菌的相关性研究 被引量:3
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作者 董锦忠 宋吉宁 刘浩明 《临床肺科杂志》 2018年第11期1974-1977,共4页
目的探讨老年非小细胞肺癌患者和肠道产丁酸菌的相关性。方法随机选择2015年2月-2017年8月确诊的40例老年非小细胞肺癌患者,从本院健康体检人群中随机选择体检健康老年人40例作为对照组,对比老年肺癌组和对照组肠道产丁酸菌表达水平。... 目的探讨老年非小细胞肺癌患者和肠道产丁酸菌的相关性。方法随机选择2015年2月-2017年8月确诊的40例老年非小细胞肺癌患者,从本院健康体检人群中随机选择体检健康老年人40例作为对照组,对比老年肺癌组和对照组肠道产丁酸菌表达水平。对老年非小细胞肺癌患者给予培美曲塞+顺铂方案进行化疗,对比化疗前后肠道产丁酸菌表达水平变化。结果老年非小细胞肺癌组的肠道产丁酸菌普拉梭菌、柔嫩梭菌、梭菌组1、直肠真杆菌、Atopobium cluster-specific primes、Roseburia spp. and E. rectale、ClusterⅣRuminococcus spp、Clostridial cluster Xl Va表达显著低于对照组,差异具有统计学意义(P <0. 05);肺癌组化疗后的肠道产丁酸菌普拉梭菌、柔嫩梭菌、梭菌组1、直肠真杆菌、Atopobium cluster-specific primes、Roseburia spp. and E. rectale、ClusterⅣRuminococcus spp、Clostridial cluster Xl Va表达显著低于化疗,差异具有统计学意义(P <0. 05)。结论老年非小细胞肺癌患者体内肠道产丁酸菌产生减少,化疗后肠道产丁酸菌产生显著低于化疗前,肠道微生态化失调可能与非小细胞肺癌患者易发感染有关。 展开更多
关键词 肠道产丁酸菌 化疗 非小细胞肺癌 老年
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芦荟大黄素对胃癌SGC-7901细胞株钙联蛋白/钙网蛋白循环及内质网应激凋亡的影响 被引量:12
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作者 宋吉宁 董锦忠 陈文礼 《中国临床研究》 CAS 2018年第6期725-729,共5页
目的探讨芦荟大黄素对胃癌SGC-7901细胞钙联蛋白(Calnexin)/钙网蛋白(Calreticulin)循环及内质网应激(ERS)所致凋亡的影响。方法将胃癌SGC-7901细胞分为对照组(灭活胎牛血清的MEM培养基培养)、低剂量组(SGC-7901细胞+10μmol/L芦荟大黄... 目的探讨芦荟大黄素对胃癌SGC-7901细胞钙联蛋白(Calnexin)/钙网蛋白(Calreticulin)循环及内质网应激(ERS)所致凋亡的影响。方法将胃癌SGC-7901细胞分为对照组(灭活胎牛血清的MEM培养基培养)、低剂量组(SGC-7901细胞+10μmol/L芦荟大黄素培养30 min)、中剂量组(SGC-7901细胞+30μmol/L芦荟大黄素培养30 min)和高剂量组(SGC-7901细胞+50μmol/L芦荟大黄素培养30 min)。细胞计数试剂盒8(CCK-8)法检测各组细胞培养24、48、72 h的细胞增殖率;脱氧核苷酸末端转移酶(Td T)介导的核苷酸(d UTP)缺口末端标记技术(TUNEL)检测各组细胞凋亡情况;实时荧光定量PCR检测各组细胞中Calnexin、Calreticulin及葡萄糖调节蛋白(GRP)78、肌醇需求酶(IRE)1、CCAAT增强子结合蛋白同源蛋白(CHOP)mRNA的变化;蛋白免疫印迹法检测各组细胞Calnexin、Calreticulin、GRP78、IRE1、CHOP的表达。结果 (1)与对照组相比,低剂量组细胞增殖率、凋亡率未见明显变化(P>0.05),中、高剂量组细胞增殖率降低、凋亡指数升高(P<0.05);(2)与对照组相比,低剂量组细胞Calnexin、Calreticulin mRNA和蛋白表达降低,而GRP78、IRE1、CHOP蛋白及mRNA表达无明显变化(P>0.05),中、高剂量组细胞Calnexin、Calreticulin蛋白及mRNA表达水平降低,GRP78、IRE1、CHOP蛋白及mRNA表达增高(P<0.05)。结论芦荟大黄素可能通过影响SGC-7901细胞Calnexin/Calreticulin循环激活GRP78/IRE1/CHOP信号通路,加重胃癌细胞ERS,引发细胞凋亡,降低细胞增殖率。 展开更多
关键词 芦荟大黄素 胃癌 凋亡 内质网应激 钙联蛋白/钙网蛋白循环
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Effects of synthetic jet frequency on the separated flow in a diffusing S-duct 被引量:1
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作者 HE Peng dong jin-zhong 《航空动力学报》 EI CAS CSCD 北大核心 2016年第2期432-442,共11页
Numerical simulations were carried out to investigate the effects of synthetic jet actuation frequency on the separated flow in a diffusing S-duct.The Reynolds number based on the entrance height was9.78×105.At f... Numerical simulations were carried out to investigate the effects of synthetic jet actuation frequency on the separated flow in a diffusing S-duct.The Reynolds number based on the entrance height was9.78×105.At first,the numerical model was validated with experimental data,and then,the interaction between the separated flow and the synthetic jets at different frequencies was discussed.The results demonstrate that the control effect is significantly dependent on the momentum mixing enhancement between inside of the separated boundary layer and the outer flow.There exists a narrow range of actuation frequency,in which effective separation control can be achieved using synthetic jets.A dimensionless frequency F+=1.0is identified as the optimal frequency,with a momentum coefficient of 1.62×10-3,the separation area is reduced about46%,and the aerodynamic performance of the S-duct is also greatly improved compared to uncontrolled case.Further analysis reveals that the choice of actuation frequency is mainly determined by the momentum flux produced by a single ejection and the spacing between adjacent ejections,the optimal frequency case can be understood as a balance between the two factors.In addition,it is found that the synthetic jets can also suppress the secondary flows while decreasing the separation. 展开更多
关键词 active flow control boundary layer separation SYNTHETIC JET ACTUATION FREQUENCY S-duct
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Experiment of heat transfer in oscillating turbulent flow in a pipe with constant heat flux
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作者 LI Ming-zhen dong jin-zhong 《航空动力学报》 EI CAS CSCD 北大核心 2013年第9期1949-1955,共7页
Heat transfer characteristics of oscillating turbulent air flow in a pipe heated with constant heat flux were experimentally investigated.The experiments were performed over a range of 245.7 to 902 of the kinetic Reyn... Heat transfer characteristics of oscillating turbulent air flow in a pipe heated with constant heat flux were experimentally investigated.The experiments were performed over a range of 245.7 to 902 of the kinetic Reynolds number and 25 to 175 of the dimensionless oscillation amplitude.The effects of these two dimensionless parameters were analyzed.The results show that the cycle-averaged local Nusselt number increases with both the kinetic Reynolds number and the dimensionless oscillation amplitude.The space-cycle averaged Nusselt number also effectively increases with the kinetic Reynolds number and the dimensionless oscillation amplitude.Based on the experimental data,a correlation equation of the space-cycle averaged Nusselt number for air in terms of these two dimensionless parameters has been obtained. 展开更多
关键词 oscillating turbulent flow heat transfer kinetic Reynolds number Nusselt number constant heat flux
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