In the southwestern Tianshan,the geologic ages of many strata and their depositional environments are still poorly constrained because of complex structures.The Mada'er area is located in the Kuokesaleling belt,South...In the southwestern Tianshan,the geologic ages of many strata and their depositional environments are still poorly constrained because of complex structures.The Mada'er area is located in the Kuokesaleling belt,Southwestern Tianshan.The cherts from the former Wupata'erkan Group contain abundant radiolarian fossils,including 10 species which are identified as late Devonian to early Carboniferous in age.Eleven chert samples have SiO_2 contents ranging from 88.80 wt%to 93.28 wt%, and 2.02 wt%to 3.72 wt%for Al_2O_3.The SiO_2/Al_2O_3 ratios of all samples vary from 23.84 to 46.11, much lower than those of the pure cherts(80-1400).These values suggest that the cherts contain high ratios of terrigenous materials.The Al_2O_3/(Al_2O_3+Fe_2O_3)ratios vary between 0.64 and 0.77,whereas V and Cu concentrations range from 10.92 ppm to 26.7 ppm and from 2.15 ppm to 34.1 ppm respectively. The Ti/V ratios vary from 25.53 to 44.93.The total REE concentrations of the cherts are between 30.78 ppm and 59.26 ppm,averaging 45.46 ppm.The(La/Ce)_N ratios range from 0.81 to 1.12,and 0.88-1.33 for(La/Yb)_N,averaging 1.09,which suggests a continental margin environment.Consequently,it is inferred that the cherts formed in a residual sea environment during the late Devonian to early Carboniferous time,which suggests that the collision between the Karakum-Tarim and Kazakhstan-Junggar plates did not occur at the time.In addition,the regional geological information indicates that the study area experienced a post-collision stage during the early Permian,and thus it is likely that the collision between the two plates took place in the late Carboniferous.展开更多
目的 检测弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者外周血中白介素-35(interleukin-35,IL-35)表达情况,探讨IL-35在DLBCL发生、发展中的作用.方法 收集40例初诊DLBCL患者和30例健康志愿者外周血,分别采用酶联...目的 检测弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者外周血中白介素-35(interleukin-35,IL-35)表达情况,探讨IL-35在DLBCL发生、发展中的作用.方法 收集40例初诊DLBCL患者和30例健康志愿者外周血,分别采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)及流式细胞术检测外周血中IL-35及调节性T细胞(regulatory T cells,Tregs)表达水平.结果 初诊DLBCL患者外周血IL-35表达水平明显升高,相比对照组差异有统计学意义(P〈0.05).Ⅲ~Ⅳ期患者IL-35表达水平显著高于I~Ⅱ期(P〈0.05).初诊DLBCL患者经过化疗后,外周血IL-35表达水平较治疗前明显下降(P〈0.05);初诊DLBCL患者外周血IL-35表达水平与患者外周血Tregs细胞比例具有正相关性(P〈0.05).结论 初诊DLBCL患者外周血IL-35表达水平升高,IL-35可能在DLBCL的发生、发展中发挥重要作用.展开更多
基金supported by National 305 Project(2007BAB25B05,2011BAB06B02- 04)NSFC grant(40925006,40772045,40572047)111 Project(B07011)
文摘In the southwestern Tianshan,the geologic ages of many strata and their depositional environments are still poorly constrained because of complex structures.The Mada'er area is located in the Kuokesaleling belt,Southwestern Tianshan.The cherts from the former Wupata'erkan Group contain abundant radiolarian fossils,including 10 species which are identified as late Devonian to early Carboniferous in age.Eleven chert samples have SiO_2 contents ranging from 88.80 wt%to 93.28 wt%, and 2.02 wt%to 3.72 wt%for Al_2O_3.The SiO_2/Al_2O_3 ratios of all samples vary from 23.84 to 46.11, much lower than those of the pure cherts(80-1400).These values suggest that the cherts contain high ratios of terrigenous materials.The Al_2O_3/(Al_2O_3+Fe_2O_3)ratios vary between 0.64 and 0.77,whereas V and Cu concentrations range from 10.92 ppm to 26.7 ppm and from 2.15 ppm to 34.1 ppm respectively. The Ti/V ratios vary from 25.53 to 44.93.The total REE concentrations of the cherts are between 30.78 ppm and 59.26 ppm,averaging 45.46 ppm.The(La/Ce)_N ratios range from 0.81 to 1.12,and 0.88-1.33 for(La/Yb)_N,averaging 1.09,which suggests a continental margin environment.Consequently,it is inferred that the cherts formed in a residual sea environment during the late Devonian to early Carboniferous time,which suggests that the collision between the Karakum-Tarim and Kazakhstan-Junggar plates did not occur at the time.In addition,the regional geological information indicates that the study area experienced a post-collision stage during the early Permian,and thus it is likely that the collision between the two plates took place in the late Carboniferous.
文摘目的 检测弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者外周血中白介素-35(interleukin-35,IL-35)表达情况,探讨IL-35在DLBCL发生、发展中的作用.方法 收集40例初诊DLBCL患者和30例健康志愿者外周血,分别采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)及流式细胞术检测外周血中IL-35及调节性T细胞(regulatory T cells,Tregs)表达水平.结果 初诊DLBCL患者外周血IL-35表达水平明显升高,相比对照组差异有统计学意义(P〈0.05).Ⅲ~Ⅳ期患者IL-35表达水平显著高于I~Ⅱ期(P〈0.05).初诊DLBCL患者经过化疗后,外周血IL-35表达水平较治疗前明显下降(P〈0.05);初诊DLBCL患者外周血IL-35表达水平与患者外周血Tregs细胞比例具有正相关性(P〈0.05).结论 初诊DLBCL患者外周血IL-35表达水平升高,IL-35可能在DLBCL的发生、发展中发挥重要作用.