AIM: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood. METHODS: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH...AIM: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood. METHODS: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: Four compounds were isolated and identified as 3α, 3β, 10β-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol(1), 4-hydroxyphenylacetic acid(2), 4-hydroxyphenethyl alcohol(3), and 5-hydroxymethyl-2-furancarboxaldehyde(4). CONCLUSION: Compound 1 was a new compound. Compound 2 showed antibacterial activity against Staphylococcus aureus.展开更多
目的系统评价过敏性鼻炎患者行热敏灸治疗与其他常规疗法的效果。方法检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(SinoMed)、维普中文科技期刊全文数据库和万方数据库以及外文Medline(from 1948),Cochrane Library(for all ...目的系统评价过敏性鼻炎患者行热敏灸治疗与其他常规疗法的效果。方法检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(SinoMed)、维普中文科技期刊全文数据库和万方数据库以及外文Medline(from 1948),Cochrane Library(for all years),Web of Science(from 1926),纳入所有使用热敏灸治疗过敏性鼻炎的临床随机对照试验(RCT),应用RevMan5.3软件对所提取的数据进行异质性检验,由检验结果选定随机效应模型对数据进行合并分析。结果最终纳入7项RCT,共计568例患者。Meta分析结果显示:热敏灸组的有效率显著高于其他常规治疗组(OR=3.31,95%CI:2.16～5.09,P<0.05),差异有统计学意义;进一步的亚组分析得出热敏灸组的有效率分别高于西药组(OR=3.26,95%CI:1.81～5.88,P<0.05)、针刺组(OR=2.93,95%CI:1.41～6.10,P<0.05)、普通艾灸组(OR=4.85,95%CI:1.43～16.42,P<0.05),差异均有统计学意义。鼻部症状体征的改善率,热敏灸组显著高于其他常规治疗组(OR=-1.54,95%CI:-1.97～-1.12,P<0.05),差异有统计学意义。结论热敏灸治疗过敏性鼻炎比其他疗法效果更好,由于纳入文献数量少、样本量少、质量偏低,存在偏倚风险,今后仍需更多大样本多中心的高质量随机对照试验验证。展开更多
基金supported by the Fundamental Research Funds for Central Public Welfare Research Institutes(Chinese Academy of Tropical Agricultural Sciences,No.1630052012014)the National Nonprofit Institute Research Grant of CATAS-ITBB130404
文摘AIM: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood. METHODS: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: Four compounds were isolated and identified as 3α, 3β, 10β-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol(1), 4-hydroxyphenylacetic acid(2), 4-hydroxyphenethyl alcohol(3), and 5-hydroxymethyl-2-furancarboxaldehyde(4). CONCLUSION: Compound 1 was a new compound. Compound 2 showed antibacterial activity against Staphylococcus aureus.
文摘目的系统评价过敏性鼻炎患者行热敏灸治疗与其他常规疗法的效果。方法检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(SinoMed)、维普中文科技期刊全文数据库和万方数据库以及外文Medline(from 1948),Cochrane Library(for all years),Web of Science(from 1926),纳入所有使用热敏灸治疗过敏性鼻炎的临床随机对照试验(RCT),应用RevMan5.3软件对所提取的数据进行异质性检验,由检验结果选定随机效应模型对数据进行合并分析。结果最终纳入7项RCT,共计568例患者。Meta分析结果显示:热敏灸组的有效率显著高于其他常规治疗组(OR=3.31,95%CI:2.16～5.09,P<0.05),差异有统计学意义;进一步的亚组分析得出热敏灸组的有效率分别高于西药组(OR=3.26,95%CI:1.81～5.88,P<0.05)、针刺组(OR=2.93,95%CI:1.41～6.10,P<0.05)、普通艾灸组(OR=4.85,95%CI:1.43～16.42,P<0.05),差异均有统计学意义。鼻部症状体征的改善率,热敏灸组显著高于其他常规治疗组(OR=-1.54,95%CI:-1.97～-1.12,P<0.05),差异有统计学意义。结论热敏灸治疗过敏性鼻炎比其他疗法效果更好,由于纳入文献数量少、样本量少、质量偏低,存在偏倚风险,今后仍需更多大样本多中心的高质量随机对照试验验证。
