Tuberculosis(TB)is a significant infectious disease caused by Mycobacterium tuberculosis(MTB).In 2017,10.0 million new TB cases and 1.3 million deaths were reported globally,according to World Health Organization(WHO)...Tuberculosis(TB)is a significant infectious disease caused by Mycobacterium tuberculosis(MTB).In 2017,10.0 million new TB cases and 1.3 million deaths were reported globally,according to World Health Organization(WHO)[1].The Mycobacterial culture test is the gold standard for diagnosis but the positive rate is only about 30%[1],and it is eve n lower with extrapulm onary tuberculosis.For sputum-negative pulmonary and extrapulm on ary TB,pathological exami nation playsan importa nt role in diag no sis.The detecti on of MTB in forma I i fixed pa raff i n-embedded(FFPE)tissues iscritical for the definite pathological diagnosis of culture-negative TB.Accurate diagnosis is essentialin reducing TB-related morbidity and mortality[2].Molecular pathological tests detecting MTB DNA have shown advantages in improving diagnostic sen sitivity.展开更多
基金supported by grants from Beijing Municipal Science and Technology Project [Grant Number:Z181100001918027]Beijing Municipal Administration of Hospitals’ Ascent Plan [No.DFL20181601,DFL20151501]Beijing Tongzhou High Level Technique Talents Program [No.YHLD2018006]
文摘Tuberculosis(TB)is a significant infectious disease caused by Mycobacterium tuberculosis(MTB).In 2017,10.0 million new TB cases and 1.3 million deaths were reported globally,according to World Health Organization(WHO)[1].The Mycobacterial culture test is the gold standard for diagnosis but the positive rate is only about 30%[1],and it is eve n lower with extrapulm onary tuberculosis.For sputum-negative pulmonary and extrapulm on ary TB,pathological exami nation playsan importa nt role in diag no sis.The detecti on of MTB in forma I i fixed pa raff i n-embedded(FFPE)tissues iscritical for the definite pathological diagnosis of culture-negative TB.Accurate diagnosis is essentialin reducing TB-related morbidity and mortality[2].Molecular pathological tests detecting MTB DNA have shown advantages in improving diagnostic sen sitivity.
