NCAPD2 serves as a potential prognostic biomarker for lung adenocarcinoma and promotes cell proliferation,migration,invasion and cell cycle in vitro

Objectives:The pro-oncogenic effects of NCAPD2 have been extensively studied across various tumor types;however,its precise role within the context of lung adenocarcinoma(LUAD)remains elusive.This study aims to elucidate the biological functions of NCAPD2 in LUAD and unravel the underlying mechanistic pathways.Methods:Utilizing bioinformatics methodologies,we explored the differential expression of NCAPD2 between normal and tumor samples,along with its correlations with clinical-pathological characteristics,survival prognosis,and immune infiltration.Results:In the TCGA-LUAD dataset,tumor samples demonstrated significantly elevated levels of NCAPD2 expression compared to normal samples(p<0.001).Clinically,higher NCAPD2 expression was notably associated with advanced T,N,and M stages,pathologic stage,gender,smoking status,and diminished overall survival(OS).Moreover,differentially expressed genes(DEGs)associated with NCAPD2 were predominantly enriched in pathways related to cell division.Immune infiltration analysis revealed that NCAPD2 expression levels were linked to the infiltration of memory B cells,naïve CD4+T cells,activated memory CD4+T cells,and M1 macrophages.In vitro experiments demonstrated that silencing NCAPD2 suppressed LUAD cell proliferation,migration,invasion,epithelial-mesenchymal transition(EMT),and cell cycle progression.Conclusions:In summary,NCAPD2 may represent a promising prognostic biomarker and novel therapeutic target for LUAD.

A Survey of English Translation Studies of Lu You’s Poetry Based on the Data Analysis of Domestic Academic Journals (2001-2022)

This article presents a comprehensive analysis of the current state of research on the English translation of Lu You’s poetry, utilizing a data sample comprising research papers published in the CNKI Full-text Database from 2001 to 2022. Employing rigorous longitudinal statistical methods, the study examines the progress achieved over the past two decades. Notably, domestic researchers have displayed considerable interest in the study of Lu You’s English translation works since 2001. The research on the English translation of Lu You’s poetry reveals a diverse range of perspectives, indicating a rich body of scholarship. However, several challenges persist, including insufficient research, limited translation coverage, and a noticeable focus on specific poems such as “Phoenix Hairpin” in the realm of English translation research. Consequently, there is ample room for improvement in the quality of research output on the English translation of Lu You’s poems, as well as its recognition within the academic community. Building on these findings, it is argued that future investigations pertaining to the English translation of Lu You’s poetry should transcend the boundaries of textual analysis and encompass broader theoretical perspectives and research methodologies. By undertaking this shift, scholars will develop a more profound comprehension of Lu You’s poetic works and make substantive contributions to the field of translation studies. Thus, this article aims to bridge the gap between past research endeavors and future possibilities, serving as a guide and inspiration for scholars to embark on a more nuanced and enriching exploration of Lu You’s poetry as well as other Chinese literature classics.

Studies on the evolution process of rockbursts in deep tunnels

This paper focuses on the evolution processes of different types of rockbursts occurring in deep tunnels. A series of laboratory tests and in-situ monitoring in deep tunnels excavated by tunnel boring machine （TBM） and drill-and-blast （D＆B） method have been conducted to understand the mechanisms and processes of the evolution of different types of rockbursts, including strain rockburst, strain-structure slip rockburst, immediate rockburst and time-delayed rockburst. Three different risk assessment methods are proposed to evaluate the intensity and potential failure depth of rockbursts. These methods can be applied before excavation and the results can be updated according to the real-time information during excavation. Two micro-seismicity based real-time warning systems have been established for predicting various intensities ofrockbursts, such as slight, moderate, intensive and extremely intensive rockbursts. Meanwhile, the probability and intensity of the rockburst are also given. The strategy for excavation and support design has been suggested for various intensities of rockbursts before excavation. The strategy for dynamic control of the rockburst evolution process is also proposed according to the monitoring results. The methodology has been successfully applied to rockburst risk reduction for deep tunnels at Jinping II hydropower project. The results have illustrated the applicability of the proposed methodology and techniques concerning rockbursts.

Analysis on Causes of "Micro-corruption" of Rural Cadres in China and Recommendations

This paper mainly introduced major manifestations of corruption of rural cadres in China,and analyzed causes of " micro-corruption" in rural areas. On the basis of analysis,it came up with pertinent recommendations for regulating " micro-corruption" of rural cadres,including improving the overall quality of village cadres,improving treatment of rural grass-roots cadres,improving grass-roots supervision system,activating the functions of rural discipline inspection commissioners,and reinforcing the punishment of " micro-corruption".

Main Problems and Government Action in Rural Land Circulation of China

On the basis of introducing and defining the concept of rural land circulation,this paper discussed the inevitability of rural land circulation in China and analyzed the main problems in the rural land circulation. Finally,it came up with some pertinent recommendations for the government in the rural land circulation in China,including formulating the relevant administrative rules and regulations,improving the rural land circulation policy system,improving the rural social security system and relieving the worry of farmers in land circulation,energetically promoting institutional construction,and actively cultivating rural land circulation market.

Government's Responsibility for Control of Agricultural Environmental Pollution in China

In this paper,the current situation of agricultural environmental pollution caused by the increase of chemicals input in agriculture in China was analyzed,and it is found that agricultural pollution is related to agricultural industrial policies,urban-rural economic structure,funds input in pollution control,comprehensive environmental management,laws of pollution control,and so forth. To control agricultural pollution effectively,it is needed to implement integration of agricultural and environmental policies,establish environmentally friendly agricultural technology popularizing system,implement integrated planning and management of a basin,and set up and improve legislation to protect agricultural environment.

A New Criterion for Defining Inhomogeneous Slope Failure Using the Strength Reduction Method

A new variational method treating the system as a whole with rigorous mathematical and physical derivation was presented in this paper.Combined with classical and engineering examples,variational energy expressions of slopes were derived.In addition,the calculation programs were written in the FISH language set in FLAC3D(fast Lagrangian analysis of continua in three dimensions)software.Factors of safety(FOSs)of the models were determined by the variational method based on the strength reduction method(SRM)and then compared with other criteria or methods.The result showed that the variational method reflected the process of slope plasticity and failure uniformly and was feasible to analyze the stability of inhomogeneous slopes.The method was applicable to both two-dimensional and three-dimensional heterogeneous slopes.The small error with other criteria or methods also showed the accuracy of this method.This method unified other criteria,avoided the artificial error of other criteria,and provided a logical derivation for the instability of heterogeneous slope.This method considered the system as a whole and avoided the shortcomings of the general method of one-sided instability analysis.The proposed method is of great significance as it considers the coupling effect of stress and strain of materials and gives the mechanical basis for the instability of complex slopes.

On the Government Function Orientation in China's Agricultural Management Reform

Since the reform and opening up,China's market-oriented agricultural management reform has achieved remarkable results,but the reform has not yet been put in place,and there are some flaws in some areas of reform.To deepen the reform of government's agricultural management reform under the new situation,it is necessary to further define the boundary between government and market on the basis of following the general rules of world's agricultural development and considering China's special situation of agriculture,nail down the scope of government functions,pinpoint the key areas of reform,and actively promote the rapid development of China's characteristic modern agriculture.

Causes of Corruption in China's Rural Areas in the New Period and Countermeasures

In the new period,corruption in China's rural areas is becoming increasingly prominent. There is frequent occurrence of violation of laws and disciplines,such as the use of power for personal gain,and corruption and bribery. Main causes for the corruption in China's rural areas include imperfect rural supervision mechanism,imperfect financial system,and low crime cost. How to deal with the increasingly serious corruption situation is a topic faced at present and in the future. It is required to continue to reinforce the democratic supervision and education of village cadres,improve the comprehensive quality of villagers,and increase the crackdown and punishment of corrupt practices,so as to guarantee healthy operation of rural authorities.

A Study on the Reform of China's Agricultural Administration System

After various reforms,China's agricultural administration system has been changing functions and improving structure,and it has basically met the requirements of agricultural and rural economic development,but in some areas,it can not be adapted to modern agricultural development. Based on the analysis of the necessity of improving agricultural administration system and the problems in current agricultural administration system,this paper comes up with the viable path choice of China's agricultural administration system reform.

System Factors for Land Corruption in China

In China,institutional factors for the land corruption include:(i)implementation of land policy lacking proper security mechanism;(ii)weak supervision system;(iii)vacancy in supervision due to dual land management system;(iv)corruption of land finance resulted from system of tax allocation;(v)imperfect land management system;(vi)poor coordination between central and local government in land policy;(vii)unreasonable land allocation system;(viii)vacancy in unified procedure and standard of land transfer.In view of these factors,this paper came up with pertinent countermeasures:(i)improving land operation mechanism and establishing sunshine land market;(ii)improving corresponding supervision mechanism and verification system;(iii)taking advantage of the audit system.

Legal Control Paths for Corruption of China's Rural Cadres

The corruption problem of China's rural cadres has exposed the weakness of the absence of legal control in rural administration. In the face of the problems in the legal control of corruption in rural cadres,it is required to improve the laws and regulations,strengthen law enforcement,and strengthen the supervision and guidance of higher-level party committee and governments to bring the corruption of rural cadres into the rule of law.

Problems and Causes of Land Corruption in China

In recent years,the land corruption in China is very serious. The amount of corruption cases is high,the links involved are various,harbor cases and fraud cases are many,the corruption subjects are mainly concentrated in government officials with high administrative level.The causes for land corruption include objective corruption opportunities and subjective corruption motivations. Only when information on land transfer is made public and accepted by the public,can it play a role in preventing land corruption.

Corruption of Village Cadres and Construction of Clean Government in Rural Land Management in China

This paper analyzed the types and causes of corruption of village cadres in rural land management in China. On the basis of current corruption situation,it came up with recommendations including improving the financial system at the village level,establishing land information network,and reforming functions of village committees in the land management,in order to prevent corruption of village cadres in the land management and establish and improve the clean government mechanism for village cadres.

On the Government's Responsibility in China's Rural Land Transfer

There is an urgent need for China's rural land transfer in order to develop modern agriculture,ensure food security,transfer rural population,and accelerate industrialization and urbanization.At present,there is still disordered transfer of rural land in China,making the interests of the transferors and transferees difficult to be effectively guaranteed;there is inefficient transfer,leading to decline in actual agricultural production level after transfer;there is jobless transfer,leading to difficult placement for rural surplus labor after transfer,seriously restricting rural land transfer.Therefore,the Chinese government's legal responsibility,economic responsibility and social responsibility in rural land transfer should be further strengthened.

Regulating electronic structure of CoN_(4)with axial Co-S for promoting oxygen reduction and Zn-air battery performance

Regulating the coordination environment of transition-metal based materials in the axial direction with heteroatoms has shown great potential in boosting the oxygen reduction reaction(ORR).The coordination configuration and the regulation method are pivotal and elusive.Here,we report a combined strategy of matrix-activization and controlled-induction to modify the CoN_(4)site by axial coordination of Co-S(Co1N_(4)-S_(1)),which was validated by the aberration-corrected electron microscopy and X-ray absorption fine structure analysis.The optimal Co1N_(4)-S_(1)exhibits an excellent alkaline ORR activity,according to the half-wave potential(0.897 V vs.reversible hydrogen electrode(RHE)),Tafel slope(24.67 mV/dec),and kinetic current density.Moreover,the Co1N_(4)-S_(1)based Zn-air battery displays a high power density of 187.55 mW/cm^(2)and an outstanding charge-discharge cycling stability for 160 h,demonstrating the promising application potential.Theoretical calculations indicate that the better regulation of CoN_(4)on electronic structure and thus the highly efficient ORR performance can be achieved by axial Co-S.

TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization

The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages,and plays a critical role in regulating inflammatory response.Our previous work has shown its role in promoting the progression of non-small cell lung cancer(NSCLC),yet the mechanism remains unclear.Here,using Tgr5-knockout mice,we show that TGR5 is required for M2 polarization of tumorassociated macrophages(TAMs)and suppresses antitumor immunity in NSCLC via involving TAMsmediated CD8+T cell suppression.Mechanistically,we demonstrate that TGR5 promotes TAMs into protumorigenic M2-like phenotypes via activating c AMP-STAT3/STAT6 signaling.Induction of c AMP production restores M2-like phenotypes in TGR5-deficient macrophages.In NSCLC tissues from human patients,the expression of TGR5 is associated with the infiltration of TAMs.The co-expression of TGR5 and high TAMs infiltration are associated with the prognosis and overall survival of NSCLC patients.Together,this study provides molecular mechanisms for the protumor function of TGR5 in NSCLC,highlighting its potential as a target for TAMs-centric immunotherapy in NSCLC.

Cobalt-based oxygen electrocatalysts for zinc-air batteries:Recent progress,challenges,and perspectives

With the rapid economic growth and the deepening awareness of sustainable development,the demand for green and efficient energy storage equipment increases.As a promising energy storage and conversion device,zinc-air batteries(ZABs)have the advantages of high theoretical specific energy density,low cost,and environmental friendliness.Nevertheless,the efficiency of ZABs is closely related to the electrocatalytic capacity of the air electrode due to its sluggish kinetics for oxygen reduction and evolution reaction(ORR/OER).Therefore,it is necessary to develop efficient catalysts to promote the reaction rate.Recently,cobalt-based materials have become a research hotspot for oxygen electrocatalysts owing to their rich natural content,high catalytic activity,and stability.In this review,the mechanisms of the OER/ORR reaction process,the catalyst's performance characterization,and the various combination methods with the current collector are systematically introduced and analyzed.Further,a broad overview of cobalt-based materials used as electrocatalysts for ZABs is presented,including cobalt-based perovskite,cobalt-nitrogen-carbon(Co-N-C)materials,cobalt oxides,cobalt-containing composite oxides,and cobalt sulfides/phosphides.Finally,various strategies for developing efficient electrocatalysts for ZABs are summarized,highlighting the challenges and future perspectives in designing novel catalysts.