基于传统面向对象方法,提出了一种基于最优特征空间的损毁建筑物信息提取方法。采用ESP(Estimate of Scale Parameter)工具对图像进行最优尺度分割,之后通过选取样本,计算各类地物距离矩阵和最小分离距离寻求最优特征空间,最后运用最优...基于传统面向对象方法,提出了一种基于最优特征空间的损毁建筑物信息提取方法。采用ESP(Estimate of Scale Parameter)工具对图像进行最优尺度分割,之后通过选取样本,计算各类地物距离矩阵和最小分离距离寻求最优特征空间,最后运用最优特征空间对震后损毁建筑物影像进行提取实验,在QuickBird影像中提取总体精度达到了83.1%, Kappa系数达到了0.813,在无人机影像中提取总体精度为92.9%, Kappa系数达到了0.940。本文建立的提取方法与传统分类决策树方法相比,其提取精度和效率都有较大提高,在损毁建筑物信息提取方面具有较好的推广价值。展开更多
Objective To review the role of cyclic adenosine monophosphate （cAMP） signal pathway in the pathogenesis of iymphoma and explore a potential lymphoma therapy targeted on this signaling pathway. Data sources The data...Objective To review the role of cyclic adenosine monophosphate （cAMP） signal pathway in the pathogenesis of iymphoma and explore a potential lymphoma therapy targeted on this signaling pathway. Data sources The data cited in this review were mainly obtained from the articles listed in Medline and PubMed, published from January 1995 to June 2009. The search terms were ＂cAMP＂ and ＂lymphoma＂. Study selection Articles regarding the role of the cAMP pathway in apoptosis of lymphoma and associated cells and its potential role in targeted therapy of lymphoma. Results In the transformation of lymphocytic malignancies, several signal pathways are involved. Among of them, the cAMP pathway has attracted increasing attention because of its apoptosis-inducing role in several lymphoma cells, cAMP pathway impairment is found to influence the prognosis of lymphoma. Targeted therapy to the cAMP pathway seems to be a new direction for lymphoma treatment, aiming at restoring the cAMP function. Conclusions cAMP signal pathway has different effects on various lymphoma cells, cAMP analogues and phosphodiesterase 4B （PDE4B） inhibitors have potential clinical significance. However, many challenges remain in understandinq the various roles of such agents.展开更多
基金This study was supported by the grants from the Natural Science Foundation of Shandong Province, China （No. Y2007C053） and the Project of Scientific and Technological Development of Shandong Province, China （No. 2007GG10002008）.
文摘Objective To review the role of cyclic adenosine monophosphate （cAMP） signal pathway in the pathogenesis of iymphoma and explore a potential lymphoma therapy targeted on this signaling pathway. Data sources The data cited in this review were mainly obtained from the articles listed in Medline and PubMed, published from January 1995 to June 2009. The search terms were ＂cAMP＂ and ＂lymphoma＂. Study selection Articles regarding the role of the cAMP pathway in apoptosis of lymphoma and associated cells and its potential role in targeted therapy of lymphoma. Results In the transformation of lymphocytic malignancies, several signal pathways are involved. Among of them, the cAMP pathway has attracted increasing attention because of its apoptosis-inducing role in several lymphoma cells, cAMP pathway impairment is found to influence the prognosis of lymphoma. Targeted therapy to the cAMP pathway seems to be a new direction for lymphoma treatment, aiming at restoring the cAMP function. Conclusions cAMP signal pathway has different effects on various lymphoma cells, cAMP analogues and phosphodiesterase 4B （PDE4B） inhibitors have potential clinical significance. However, many challenges remain in understandinq the various roles of such agents.
