To solve the difficulties in exploration and development in Yuanba ultra-deep gas field in Sichuan Basin,SW China,the article studies the mechanism of quality reef reservoirs development and gas accumulation and innov...To solve the difficulties in exploration and development in Yuanba ultra-deep gas field in Sichuan Basin,SW China,the article studies the mechanism of quality reef reservoirs development and gas accumulation and innovates techniques in ultra-deep seismic exploration,drilling,completion and testing.Through the reconstruction of dynamic depositional evolution process and regional depositional framework of homoclinal ramp-rimmed platform in Upper Permian,three theories are put forward:first,"early beach-late reef,multiple stacking,arrangement in rows and belts"is the sedimentary mode for the reservoirs in the Changxing Formation of Yuanba area;second,"dissolution in early exposure stage and dolomitization during shallow burial giving rise to the pores in matrix,overpressure caused by cracking of liquid hydrocarbon during deep burial inducing fractures"is the reservoirs development mechanisms;third,"coupling of pores and fractures"controls the development of high quality reservoirs in deep formations.From correlation of oil and source rock,it is concluded that the Wujiaping Formation and Dalong Formation of deep-water continental shelf are the major source rocks in the Permian of northern Sichuan Basin.The hydrocarbon accumulation mode in ultra-deep formations of low-deformation zones is characterized by"three-micro(micro-fault,micro-fracture interbed crack)migration,near-source enrichment,and persistent preservation".Through seismic inversion using the pore structure parameters of pore-fracture diadactic structure model,the high production gas enrichment area in Yuanba gas field is 98.5 km^2.Moreover,special well structure and unconventional well structure were used to deal with multiple pressure systems and sealing of complex formations.A kind of integral,high pressure resistant FF-level gas wellhead and ground safety linkage device was developed to accomplish safe and environmentally friendly gas production.展开更多
目的:评价中医药治疗表皮生长因子受体抑制剂(EGFRIs)相关皮疹的疗效及安全性。方法:在外文Web of Science、PubMed、Cochrane Library和维普数据库(VIP)、中国学术期刊全文数据库(CNKI)、万方数据库中检索从创建以来至2018年3月关于中...目的:评价中医药治疗表皮生长因子受体抑制剂(EGFRIs)相关皮疹的疗效及安全性。方法:在外文Web of Science、PubMed、Cochrane Library和维普数据库(VIP)、中国学术期刊全文数据库(CNKI)、万方数据库中检索从创建以来至2018年3月关于中医药治疗EGFRIs相关皮疹的随机对照试验,并手工检索补充相应文献。由研究人员对文献进行筛选和数据提取,并用Rev Man5.3进行异质性检验、敏感性分析和Meta分析。结果:纳入21项研究,共1394例肿瘤患者,Meta分析结果显示中医药治疗EGFRIs相关皮疹的有效率、减轻皮肤瘙痒的有效率、中医症状缓解的有效率明显优于对照组(P<0.01),且中医药观察组的患者生命质量明显改善,极少出现治疗相关的不良反应。实体瘤治疗总有效率与未予中医药观察组相当(P>0.05)。结论:中医药治疗可明显缓解EGFRIs相关皮疹和瘙痒,明显缓解中医证候,提高患者的生命质量,且不影响EGFRI的抗肿瘤疗效。展开更多
基金Supported by the National Natural Science Foundation of China(U1663210)
文摘To solve the difficulties in exploration and development in Yuanba ultra-deep gas field in Sichuan Basin,SW China,the article studies the mechanism of quality reef reservoirs development and gas accumulation and innovates techniques in ultra-deep seismic exploration,drilling,completion and testing.Through the reconstruction of dynamic depositional evolution process and regional depositional framework of homoclinal ramp-rimmed platform in Upper Permian,three theories are put forward:first,"early beach-late reef,multiple stacking,arrangement in rows and belts"is the sedimentary mode for the reservoirs in the Changxing Formation of Yuanba area;second,"dissolution in early exposure stage and dolomitization during shallow burial giving rise to the pores in matrix,overpressure caused by cracking of liquid hydrocarbon during deep burial inducing fractures"is the reservoirs development mechanisms;third,"coupling of pores and fractures"controls the development of high quality reservoirs in deep formations.From correlation of oil and source rock,it is concluded that the Wujiaping Formation and Dalong Formation of deep-water continental shelf are the major source rocks in the Permian of northern Sichuan Basin.The hydrocarbon accumulation mode in ultra-deep formations of low-deformation zones is characterized by"three-micro(micro-fault,micro-fracture interbed crack)migration,near-source enrichment,and persistent preservation".Through seismic inversion using the pore structure parameters of pore-fracture diadactic structure model,the high production gas enrichment area in Yuanba gas field is 98.5 km^2.Moreover,special well structure and unconventional well structure were used to deal with multiple pressure systems and sealing of complex formations.A kind of integral,high pressure resistant FF-level gas wellhead and ground safety linkage device was developed to accomplish safe and environmentally friendly gas production.
文摘目的:评价中医药治疗表皮生长因子受体抑制剂(EGFRIs)相关皮疹的疗效及安全性。方法:在外文Web of Science、PubMed、Cochrane Library和维普数据库(VIP)、中国学术期刊全文数据库(CNKI)、万方数据库中检索从创建以来至2018年3月关于中医药治疗EGFRIs相关皮疹的随机对照试验,并手工检索补充相应文献。由研究人员对文献进行筛选和数据提取,并用Rev Man5.3进行异质性检验、敏感性分析和Meta分析。结果:纳入21项研究,共1394例肿瘤患者,Meta分析结果显示中医药治疗EGFRIs相关皮疹的有效率、减轻皮肤瘙痒的有效率、中医症状缓解的有效率明显优于对照组(P<0.01),且中医药观察组的患者生命质量明显改善,极少出现治疗相关的不良反应。实体瘤治疗总有效率与未予中医药观察组相当(P>0.05)。结论:中医药治疗可明显缓解EGFRIs相关皮疹和瘙痒,明显缓解中医证候,提高患者的生命质量,且不影响EGFRI的抗肿瘤疗效。
