骨疏方治疗绝经后骨质疏松症及抗氧化应激作用的临床研究

目的:观察骨疏方治疗女性绝经后骨质疏松症(Postmenopausal Osteoporosis,PMOP)的临床疗效,并探讨其抗氧化应激介导骨质疏松的作用机制。方法:选取患者共150例,随机分为五组,每组30例。4个治疗组予骨疏方,对照组予阿尔法骨化醇软胶囊。结果:6个月后五组疗效指数均≥70%(P<0.05),治疗组疗效更为显著,与对照组相比差异具有统计学意义(P<0.05)。各组总有效率:肾阳虚组83.33%、肝肾阴虚组90.00%、脾肾阳虚组86.67%、肾虚血瘀组83.33%,对照组73.33%,差异有统计学意义(P<0.05)。五组骨密度均有增加,各组治疗后与治疗前比较差异有统计学意义(P<0.05)。4个治疗组较对照组骨密度增加更加明显,差异有统计学意义(P<0.05)。五组骨代谢相关指标均有不同程度的改善,各组与治疗前比较差异有统计学意义(P<0.05)。4个治疗组较对照组骨代谢相关指标改善更为明显,差异有统计学意义(P<0.05)。五组患者活性氧相关指标均与治疗前相比均有不同程度的改善,差异有统计学意义(P<0.05)。治疗后4个治疗组活性氧指标相比对照组改善更加明显,差异有统计学意义(P<0.05)。五组共有9例受试者发生不良反应,全部耐受未退出试验。结论:骨疏方具有较好的抗氧化应激作用且治疗PMOP具有良好的疗效,及较高的安全性。

Thermal conductivity behavior of SPS consolidated AlN/Al composites for thermal management applications

A1N/A1 composites are a potentially new kind of thermal management material for electronic packaging and heat sink applications. The spark plasma sintering （SPS） technique was used for the first time to prepare the A1N/A1 composites, and attention was focused on the effects of sintefing parameters on the relative density, microstructure and, in particular, thermal conductivity behavior of the composites. The results showed that the relative density and thermal conductivity of the composites increased with increasing sintering temperature and pressure. The composites sintered at 1550℃ for 5 min under 70 MPa showed the maximum relative density and thermal conductivity, corresponding to 99% and 97.5 W.m-1.K-1, respectively. However, the thermal conductivity of present A1N/A1 composites is still far below the theoretical value. Possible reasons for this deviation were discussed.