In order to assess the vascular integrity after heart transplantation (HTx), intracoronary Doppler was performed in 13 patients within 3 months after HTx and at one year follow up in all the 3 epicardial coronary art...In order to assess the vascular integrity after heart transplantation (HTx), intracoronary Doppler was performed in 13 patients within 3 months after HTx and at one year follow up in all the 3 epicardial coronary arteries (LAD, LCX, and RCA) For intracoronary Doppler flow mapping, a 0 014 inch,15 MHz FloWire (Cardiometrics) was used Coromary flow velocity reserve (CFR) was derived by calculating the ratio between average peak flow velocity (APV) at baseline and after intracoronary adenosine injection (LAD and LCX, 18?μg; RCA, 12?μg) All patients were found to have relatively normal coronary angiograms within 3 months and at one year follow up CFVR was increased significantly in LAD (2 87±0 59 vs 3 63±0 91, P <0 05) and LCX (2 38±0 76 vs 3 27±0 75, P <0 01) at 1 year follow up in comparison to the baseline No significant increase in the RCA was found (3 13±1 62 vs 3 33±1 10, P > 0 05) Reduction of CFR exists within 3 months after HTx and normalises within one year This indicates that microvascular dysfunction especially in LAD and LCX exists early after HTx which will be normalised at 1 year CFR of the RCA seems to recover early HTx展开更多
文摘In order to assess the vascular integrity after heart transplantation (HTx), intracoronary Doppler was performed in 13 patients within 3 months after HTx and at one year follow up in all the 3 epicardial coronary arteries (LAD, LCX, and RCA) For intracoronary Doppler flow mapping, a 0 014 inch,15 MHz FloWire (Cardiometrics) was used Coromary flow velocity reserve (CFR) was derived by calculating the ratio between average peak flow velocity (APV) at baseline and after intracoronary adenosine injection (LAD and LCX, 18?μg; RCA, 12?μg) All patients were found to have relatively normal coronary angiograms within 3 months and at one year follow up CFVR was increased significantly in LAD (2 87±0 59 vs 3 63±0 91, P <0 05) and LCX (2 38±0 76 vs 3 27±0 75, P <0 01) at 1 year follow up in comparison to the baseline No significant increase in the RCA was found (3 13±1 62 vs 3 33±1 10, P > 0 05) Reduction of CFR exists within 3 months after HTx and normalises within one year This indicates that microvascular dysfunction especially in LAD and LCX exists early after HTx which will be normalised at 1 year CFR of the RCA seems to recover early HTx
