Two new triterpene esters, 2-O-caffeoylalphitolic acid (1) and methyl 2-O-caffeoyl- alphitolate (2), together with two known triterpenes were isolated from the shrub Daphniphyllum oldhami. The structures of new compou...Two new triterpene esters, 2-O-caffeoylalphitolic acid (1) and methyl 2-O-caffeoyl- alphitolate (2), together with two known triterpenes were isolated from the shrub Daphniphyllum oldhami. The structures of new compounds were elucidated on the basis of detailed spectroscopic analysis and compared with related compound.展开更多
In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase （ACHE） inhibition, two main ingredients, salvianolic acid B...In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase （ACHE） inhibition, two main ingredients, salvianolic acid B （1） and rosmarinic acid （2）, which were isolated from S. miltiorhiza water extract, were investigated in vitro by NMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have ACHE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.展开更多
A novel 8,4＇-oxyneolignan diglycoside,named ligusinenoside d（1）,was isolated from the rhizomes of Ligusticum sinensis, together with five known analogues 2-6.The absolute configurations of 1 and 2 were elucidated b...A novel 8,4＇-oxyneolignan diglycoside,named ligusinenoside d（1）,was isolated from the rhizomes of Ligusticum sinensis, together with five known analogues 2-6.The absolute configurations of 1 and 2 were elucidated by means of enzymatic hydrolysis and spectroscopic data.展开更多
基金supportd by the National Natural Science foundation for Outstanding Youth(30125044)partly funded by the"foundation for scholars come back from abroad"provided by Ministry of Education,Ministry of Personnel,and Chinese academy of Sciences.
文摘Two new triterpene esters, 2-O-caffeoylalphitolic acid (1) and methyl 2-O-caffeoyl- alphitolate (2), together with two known triterpenes were isolated from the shrub Daphniphyllum oldhami. The structures of new compounds were elucidated on the basis of detailed spectroscopic analysis and compared with related compound.
基金The authors are grateful for supports by the National Natural Science Foundation of China （No. 90409015 and 20473013）.
文摘In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase （ACHE） inhibition, two main ingredients, salvianolic acid B （1） and rosmarinic acid （2）, which were isolated from S. miltiorhiza water extract, were investigated in vitro by NMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have ACHE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.
基金financial support of this work by the science fund for scholars from Lanzhou University of Technology(No.BS08201001)
文摘A novel 8,4＇-oxyneolignan diglycoside,named ligusinenoside d（1）,was isolated from the rhizomes of Ligusticum sinensis, together with five known analogues 2-6.The absolute configurations of 1 and 2 were elucidated by means of enzymatic hydrolysis and spectroscopic data.
