Objective:To evaluate the clinical application of proton magnetic resonance spectroscopy(1HMRS)in patients with radiotherapy treated intracranial tumors.Methods:Forty patients with intracranial tumors underwent multiv...Objective:To evaluate the clinical application of proton magnetic resonance spectroscopy(1HMRS)in patients with radiotherapy treated intracranial tumors.Methods:Forty patients with intracranial tumors underwent multivoxel 1HMRS examination before and after radiotherapy.The concentrations of N-acetyl aspartate(NAA),choline(Cho)and creatine(Cr) were obtained both in the tumors and the contralateral normal brain regions.The ratios of NAA/Cr,Cho/Cr and Cho/NAA were calculated at the same time and follow-up one year.Results:(1)After radiotherapy,tumors inhibited by radiation had decreased Cho,NAA and Cr on proton MRS.Some cases showed necrotic wave.(2)During the one year follow-up,local tumor recurred in 8 cases and their Cho and Cho/NAA increased high again.Other cases without recurrence,1HMRS showed no change.Conclusion:Multivoxel proton MR spectroscopy is available for study of tumor metabolites after radiotherapy and it is a valuable method in the evaluation of radiotherapy treated tumors.展开更多
基金a grant from the Medical Foundation of Wu Jieping(No.32067000501).
文摘Objective:To evaluate the clinical application of proton magnetic resonance spectroscopy(1HMRS)in patients with radiotherapy treated intracranial tumors.Methods:Forty patients with intracranial tumors underwent multivoxel 1HMRS examination before and after radiotherapy.The concentrations of N-acetyl aspartate(NAA),choline(Cho)and creatine(Cr) were obtained both in the tumors and the contralateral normal brain regions.The ratios of NAA/Cr,Cho/Cr and Cho/NAA were calculated at the same time and follow-up one year.Results:(1)After radiotherapy,tumors inhibited by radiation had decreased Cho,NAA and Cr on proton MRS.Some cases showed necrotic wave.(2)During the one year follow-up,local tumor recurred in 8 cases and their Cho and Cho/NAA increased high again.Other cases without recurrence,1HMRS showed no change.Conclusion:Multivoxel proton MR spectroscopy is available for study of tumor metabolites after radiotherapy and it is a valuable method in the evaluation of radiotherapy treated tumors.
