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同时性多发早期胃癌的临床特征及主次病灶之间的相关性分析 被引量:3
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作者 陈达巍 傅孙亚 +3 位作者 诸娴 沈睿炜 任辉 沈建伟 《中国内镜杂志》 2020年第4期45-49,共5页
目的探究同时性多发早期胃癌(SMEGC)的临床病理学特征以及主要病灶与次要病灶之间的相关性。方法回顾性研究2016年1月-2019年4月在宁波市医疗中心李惠利医院经内镜黏膜下剥离术(ESD)治疗的305例早期胃癌患者的病历资料,收集患者的年龄... 目的探究同时性多发早期胃癌(SMEGC)的临床病理学特征以及主要病灶与次要病灶之间的相关性。方法回顾性研究2016年1月-2019年4月在宁波市医疗中心李惠利医院经内镜黏膜下剥离术(ESD)治疗的305例早期胃癌患者的病历资料,收集患者的年龄、性别、肿瘤宏观形态、位置、直径、有无溃疡、表面有无发红、组织病理学类型和浸润深度等情况,分析SMEGC与单发早期胃癌的临床病理特征的差异以及主次病灶之间的相关性。结果所有早期胃癌患者中,25例(8.2%)为SMEGC,280例(91.8%)为单发早期胃癌;SMEGC患者年龄>60岁的比例(76.0%,19/25)高于单发早期胃癌(52.9%,148/280);肿瘤直径≤2.00 cm的比例(68.0%,17/25)高于单发早期胃癌(46.1%,129/280),差异有统计学意义(P<0.05)。两组患者性别、肿瘤宏观形态、位置、有无溃疡、表面有无发红、组织病理学类型、浸润深度差异均无统计学意义(P>0.05)。SMEGC主要病灶直径明显大于次要病灶,差异有统计学意义(P<0.05)。而主次病灶的肿瘤宏观形态、位置、有无溃疡、表面有无发红、组织病理学类型和浸润深度差异均无统计学意义(P>0.05)。结论SMEGC的预测危险因素是60岁以上的患者、直径不超过2.00 cm的肿瘤,主次病灶的临床病理特征相似,包含这些因素的早期胃癌患者应该进行更仔细的内镜检查,注意主次病灶间的相关性,提高SMEGC的检出率。 展开更多
关键词 多发早期胃癌 内镜黏膜下剥离术 同时性 主要病灶 次要病灶
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预切开内镜下黏膜切除术与内镜黏膜下剥离术治疗十二指肠非壶腹部病变的疗效及安全性比较 被引量:6
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作者 陈达巍 傅孙亚 +2 位作者 陈达华 林洁琼 沈建伟 《中国内镜杂志》 2022年第5期27-32,共6页
目的比较预切开内镜下黏膜切除术(Pre-cut-EMR)与内镜黏膜下剥离术(ESD)治疗十二指肠非壶腹部病变的临床疗效及安全性。方法回顾性分析2015年6月-2021年6月宁波市医疗中心李惠利医院64例确诊为十二指肠非壶腹部病变的患者的临床资料。其... 目的比较预切开内镜下黏膜切除术(Pre-cut-EMR)与内镜黏膜下剥离术(ESD)治疗十二指肠非壶腹部病变的临床疗效及安全性。方法回顾性分析2015年6月-2021年6月宁波市医疗中心李惠利医院64例确诊为十二指肠非壶腹部病变的患者的临床资料。其中,30例行Pre-cut-EMR,34例行ESD。比较两组患者病灶特征、手术时间、并发症发生率、整块切除率、R0切除率和术后组织病理学结果。结果两组患者病灶宏观形态、迟发性出血、整块切除率、R0切除率和术后病理等比较,差异均无统计学意义(P>0.05)。所有患者均成功完成内镜下切除,整块切除率为100.0%,总体R0切除率为96.9%,术后均未发生迟发性穿孔。Pre-cut-EMR组手术时间为(24.6±6.5)min,明显短于ESD组的(37.5±9.5)min,术中穿孔率为3.3%(1/30),明显低于ESD组的23.5%(8/34),差异均有统计学意义(P<0.05)。Pre-cut-EMR组病灶直径为1.40(1.30,1.70)cm,小于ESD组的1.45(1.30,2.00)cm,但差异无统计学意义(P>0.05);Pre-cut-EMR组病灶直径≥2.0 cm的比例为10.0%(3/30),低于ESD组的32.4%(11/34),差异有统计学意义(P<0.05)。结论Pre-cut-EMR和ESD治疗十二指肠非壶腹部病变的疗效相当,但Pre-cut-EMR手术时间更短,术中穿孔率更低,治疗直径<2.0 cm的病灶是安全有效的。 展开更多
关键词 十二指肠非壶腹病变 预切开内镜下黏膜切除术 内镜黏膜下剥离术 并发症
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Numerical study on wake characteristics of high-speed trains 被引量:20
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作者 Shuan-Bao Yao Zhen-Xu Sun +2 位作者 Di-Long Guo da-wei chen Guo-Wei Yang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2013年第6期811-822,共12页
Intensive turbulence exists in the wakes of high speed trains, and the aerodynamic performance of the trailing car could deteriorate rapidly due to complicated features of the vortices in the wake zone. As a result, t... Intensive turbulence exists in the wakes of high speed trains, and the aerodynamic performance of the trailing car could deteriorate rapidly due to complicated features of the vortices in the wake zone. As a result, the safety and amenity of high speed trains would face a great challenge. This paper considers mainly the mechanism of vortex formation and evolution in the train flow field. A real CRH2 model is studied, with a leading car, a middle car and a trailing car included. Different running speeds and cross wind conditions are considered, and the approaches of un- steady Reynold-averaged Navier-Stokes (URANS) and de- tached eddy simulation (DES) are utilized, respectively. Re- suits reveal that DES has better capability of capturing small eddies compared to URANS. However, for large eddies, the effects of two approaches are almost the same. In conditions without cross winds, two large vortex streets stretch from the train nose and interact strongly with each other in the wake zone. With the reinforcement of the ground, a complicated wake vortex system generates and becomes strengthened as the running speed increases. However, the locations of flow separations on the train surface and the separation mechanism keep unchanged. In conditions with cross winds, three large vortices develop along the leeward side of the train, among which the weakest one has no obvious influence on the wake flow while the other two stretch to the tail of the train and combine with the helical vortices in the train wake. Thus, optimization of the aerodynamic performance of the trailing car should be aiming at reducing the intensity of the wake vortex system. 展开更多
关键词 Wake flow structures URANS DES High speed trains
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Aerodynamic modeling and stability analysis of a high-speed train under strong rain and crosswind conditions 被引量:14
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作者 Xue-ming SHAO Jun WAN +1 位作者 da-wei chen Hong-bing XIONG 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2011年第12期964-970,共7页
With the development of high-speed train,it is considerably concerned about the aerodynamic characteristics and operation safety issues of the high-speed train under extreme weather conditions.The aerodynamic performa... With the development of high-speed train,it is considerably concerned about the aerodynamic characteristics and operation safety issues of the high-speed train under extreme weather conditions.The aerodynamic performance of a high-speed train under heavy rain and strong crosswind conditions are modeled using the Eulerian two-phase model in this paper.The impact of heavy rainfall on train aerodynamics is investigated,coupling heavy rain and a strong crosswind.Results show that the lift force,side force,and rolling moment of the train increase significantly with wind speed up to 40 m/s under a rainfall rate of 60 mm/h.when considering the rain and wind conditions.The increases of the lift force,side force,and rolling moment may deteriorate the train operating safety and cause the train to overturn.A quasi-static stability analysis based on the moment balance is used to determine the limit safety speed of a train under different rain and wind levels.The results can provide a frame of reference for the train safe operation under strong rain and crosswind conditions. 展开更多
关键词 High-speed train Aerodynamic characteristics Multiphase flow RAIN CROSSWIND OVERTURNING
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Numerical study on the aerodynamic performance and safe running of high-speed trains in sandstorms 被引量:7
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作者 Hong-bing XIONG Wen-guang YU +1 位作者 da-wei chen Xue-ming SHAO 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2011年第12期971-978,共8页
The influence of sandstorms on train aerodynamic performance and safe running was studied in response to the frequent occurrence of sandstorm weather in north China.An Eulerian two-phase model in the computational flu... The influence of sandstorms on train aerodynamic performance and safe running was studied in response to the frequent occurrence of sandstorm weather in north China.An Eulerian two-phase model in the computational fluid dynamic (CFD) software FLUENT,validated with published data,was used to solve the gas-solid multiphase flow of a sandstorm around a train.The train aerodynamic performance under different sandstorm levels and no sand conditions was then simulated.Results showed that in sandstorm weather,the drag,lift,side forces and overturning moment increase by variable degrees.Based on a numerical analysis of aerodynamic characteristics,an equation of train stability was also derived using the theory of moment balance from the view of dynamics.A recommended speed limit of a train under different sandstorm levels was calculated based on the stability analysis. 展开更多
关键词 High-speed train SANDSTORM Gas-solid multiphase Eulerian two-phase model Aerodynamic Safety Speed limit
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Unsteady simulation for a high-speed train entering a tunnel 被引量:9
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作者 Xin-hua LI Jian DENG +2 位作者 da-wei chen Fang-fang XIE Yao ZHENG 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2011年第12期957-963,共7页
In order to study the unsteady aerodynamics effects in railway tunnels,the 3D Reynolds average Navier-Stokes equations of a viscous compressible fluid are solved,and the two-equation k-ε model is used in the simulati... In order to study the unsteady aerodynamics effects in railway tunnels,the 3D Reynolds average Navier-Stokes equations of a viscous compressible fluid are solved,and the two-equation k-ε model is used in the simulation of turbulence,while the dynamic grid technique is employed for moving bodies.We focus on obtaining the changing tendencies of the aerodynamic force of the train and the aerodynamic pressures on the tunnel wall and train surface,and discovering the relationship between the velocity of the train and the intensity of the micro pressure wave at the tunnel exit.It is shown that the amplitudes of the pressure changes in the tunnel and on the train surface are both approximately proportional to the square of the train speed,so are the microwave and the drag of the train. 展开更多
关键词 High-speed train AERODYNAMICS Railway tunnel Numerical analysis
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Imprinting methylation and assisted reproductive technology
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作者 Yan HAO Zhi-guo ZHANG +8 位作者 Dan HAN Ping ZHOU Yun-xia CAO Zhao-lian WEI Dong-mei JI Bei-li chen Wei-wei ZOU da-wei chen Fu-xi ZHU 《Journal of Reproduction and Contraception》 CAS CSCD 2015年第2期112-120,共9页
Assisted reproductive technology (ART) is an important treatment for infertile people of reproductive age and is also known as fertility treatment. The processes of ART involves the isolation, handling and culture o... Assisted reproductive technology (ART) is an important treatment for infertile people of reproductive age and is also known as fertility treatment. The processes of ART involves the isolation, handling and culture of early embryos, which may result in alterations in genomic methylation at specific loci and influence the proper establishment and maintenance of genomic imprints. Recent studies have identified an increased incidence of imprinting disorders via ART. In this article, we reviewed that the ART may be prone to induction of imprinting methylation errors during embryonic development. Further studies are necessary to elucidate the safety of ART in this field. 展开更多
关键词 IMPRINTING METHYLATION assisted reproductive technology (ART) disoder EPIGENETICS
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