Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice

The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD.

中国监狱红色文化资源的保护与开发利用

新中国监狱在其发展历程中,取得了令人瞩目的成绩,也创造了独特而鲜明的监狱红色文化。中国监狱红色文化资源具有忠于党、忠于人民的政治忠诚性,百折不挠的坚韧性和攻坚克难的勇毅性。监狱红色文化资源对于推动社会主义精神文明建设具有重要作用。在推进社会主义精神文明建设的进程中,中国监狱红色文化资源的保护与开发利用可以从以下方面着手:将监狱红色文化融入地方特色文化,发挥红色文化的教育功能,加强监狱红色文化的话语体系建设具有重要的现实意义。

A Localization Method of High Energy Transients for All-sky Gamma-ray Monitor

Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up observations.Localization based on the relative counts of different detectors has been widely used for all-sky gamma-ray monitors.There are two major methods for this count distribution localization:χ^(2)minimization method and the Bayesian method.Here we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the χ^(2)method.With comprehensive simulations,we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than the χ^(2)method,especially for weak bursts.We further proposed a location-spectrum iteration approach based on the Bayesian inference,which could alleviate the problems caused by the spectral difference between the burst and location templates.Our method is very suitable for scenarios with limited computation resources or timesensitive applications,such as in-flight localization software,and low-latency localization for rapidly follow-up observations.

低熔点玻璃粉包覆FeSiAl合金的结构和电磁性能

将低熔点玻璃粉D250绝缘包覆剂与扁平化的FeSiAl合金粉末机械混合,进行热处理使D250熔融流动而包覆在片状FeSiAl粉末表面。借助XRD,SEM,XRF和EDS等手段研究了包覆后粉末的物相组成、表面形貌和元素组成;用矢量网络分析仪测试了材料在1~18 GHz频率范围内的电磁参数和反射损耗。结果表明,熔融包覆后的粉末形成均匀致密的包覆层,其复介电常数的实部降低到8左右。热处理温度为700℃时材料的最大反射损耗降至-40.10dB,有效频宽达到3.76 GHz。

FGF/FGFR signaling in health and disease

Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

Description of mixed symmetry states in 96Ru using IBM-2

We have investigated the properties of low-tyiag states iu 96Ru within the framework of the neutron-proton interacting boson model （IBM-2）, with special attention paid to the characteristics of the mixed symmetry states. By considering the relative energy of d proton boson to be different from that of neutron boson, the level energies and M1, E2 transition strengths have been calculated. The IBM-2 calculation is consistent with the experimental data of 96Ru both quantitatively and qualitatively. Particularly, the strong M1 transition between the 42^＋ and 41^＋ states has been reproduced nicely. The calculated results show that the M1 transition strength of B（M1,42^＋ → 41^＋） in 96Ru carl be described successfully by the IBM-2.

Nuclear structure of ^(76)Ge from proton-neutron interacting boson model calculations

The properties of low-lying states in 76Ge, especially the characteristics of the mixed-symmetry states, have been investigated within the neutron-proton interacting boson model （IBM-2）. By considering the relative energy of d proton boson to be different from that of neutron boson, the low-lying positive parity levels and M1, E2 transition strengths have been calculated. The IBM-2 calculated results are in good agreement with the experimental data. Particularly, the mixed-symmetry states have been reproduced quite well. The calculation and systematic analysis demonstrated that the collective character of 76Ge lies closest to the SUπv^＊（3）, with some possible Oπv（6） dynamic symmetry in IBM-2 viewpoint.

Description of spectrum and electromagnetic transitions in ^(94)Mo through the proton-neutron interacting boson model

We investigated the properties of low-lying states in ^(94)Mo within the framework of the proton-neutron interacting boson model(IBM-2), with special focus on the characteristics of mixed-symmetry states. We calculated level energies and M1 and E2 transition strengths. The IBM-2 results agree with the available quantitative and qualitative experimental data on ^(94)Mo. The properties of mixed-symmetry states can be well described by IBM-2 given that the energy of the d proton boson is different from that of the neutron boson, especially for the transition of B(M1, 4_2^+→ 4_1^+).

Result of proton beam energy calibration of GECAM satellite charged particle detector

Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the proton detection ability of a CPD and deriving the energy response to charged particles of the CPD in the two designed operating modes is important.Method The proton calibration tests of the CPD under diferent working modes were carried out at the Heavy Ion Research Facility in Lanzhou.Result and conclusion Through testing and analysis,it was concluded that when CPD works in semi-component mode,it can detect the maximum energy,and when working in full-component mode,it can provide better energy resolution.

Description of the shape coexistence in neutron-deficient ^(74,76)Kr with IBM2

The shape deformation and shape coexistence in ^(74,76) Kr isotopes are investigated within the framework of the proton-neutron interacting boson model(IBM2). By considering the relative energy of the d proton boson to be different from that of the neutron boson, the low-lying energy spectrum is in good agreement with experimental results both qualitatively and quantitatively. In particular, the low-lying 0_2^+ states associated with the shape-coexistence phenomenon are reproduced quite well. The calculated key sensitive quantities of B(E2) transition branch ratios are fairly consistent with the experimental data except for R_4. The predicated deformation parameter is very similar for the ground states in ^(74)Kr and ^(76)Kr, showing good agreement with the experimental result,and the calculated deformation parameter for the second 0^+ state in ^(74)Kr is close to the experimental data. The calculated results of the triaxiality parameter indicated an almost purely prolate shape for the ground state of ^(76)Kr and a mostly prolate shape with a little triaxiality for the ground state of ^(74)Kr. The calculations also show an oblate triaxial shape for the second 0^+ state in ^(76)Kr and maximum triaxiality for the second 0^+ state in ^(74)Kr. These results confirm the importance of the triaxial deformation for the description of such shape coexistence.

MAFLD was more easily diagnosed than NAFLD in liver transplant recipients with abnormal liver function

Background and aims:Nonalcoholic fatty liver disease(NAFLD)is hepatic steatosis that is require the exclusion of certain etiologies,including drug usage or alcoholic consumption.Conversely,metabolic dysfunction-associated fatty liver disease(MAFLD)needs not to.In this study,we aimed to examine whether MAFLD is more easily diagnosed than NAFLD in liver transplant(LT)recipients with abnormal liver function.Methods:In this cross-sectional study,LT recipients with abnormal liver function were investigated for the prevalence of MAFLD and NAFLD.Results:We recruited 57 LT recipients with abnormal liver function at a referral hospital.Among these patients,the prevalence of MAFLD and NAFLD was 37.8%and 11.1%,respectively.17 patients showed hepatic steatosis,with an average NAFLD activity score of 3.5 and a fibrosis score of 1.0.Compared with non-MAFLD patients,MAFLD patients had a significant difference in fasting blood glucose levels(p?0.009).Among 17 MAFLD patients,12 were overweight and four were diagnosed with diabetes mellitus.The majority of MAFLD diagnoses were based on body mass index(70.6%)and diabetes mellitus history(23.5%),biomarkers that are easily obtained.At 6,12,24,and 36 months after LT,MAFLD patients had higher levels of fasting blood glucose(6 months:p?0.004,12 months:p?0.038)and higher trend of body mass index value and plasma triglyceride level but no significance.Conclusions:MAFLD was more easily diagnosed in LT recipients with abnormal liver function and higher in prevalence than NAFLD.A larger sample size research is required to validate these conclusions.