Pancreatic cancer is one of the deadliest malignancies,with limited effectiveness of standard therapies,resulting in little improvement in the 5-year survival rate over the past few decades.However,advanced radiothera...Pancreatic cancer is one of the deadliest malignancies,with limited effectiveness of standard therapies,resulting in little improvement in the 5-year survival rate over the past few decades.However,advanced radiotherapy techniques and emerging treatment modalities,such as immunotherapy and targeted therapy,are showing tremendous potential as effective treatment options for pancreatic cancer patients who were previously considered incurable.This review summarizes the current advances and challenges in pancreatic cancer treatment strategies and proposes further optimization directions,aiming to provide insights into the cure of incurable pancreatic cancer.展开更多
Pancreatic cancer is one of the most lethal malignancies.Significant progresses have been made in understanding of pancreatic cancer pathogenesis,including appreciation of precursor lesions or premalignant pancreatic ...Pancreatic cancer is one of the most lethal malignancies.Significant progresses have been made in understanding of pancreatic cancer pathogenesis,including appreciation of precursor lesions or premalignant pancreatic intraepithelial neoplasia(PanINs),description of sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and identification of major genetic and epigenetic events and the biological impact of those events on malignant behavior.However,the currently used therapeutic strategies targeting tumor epithelial cells,which are potent in cell culture and animal models,have not been successful in the clinic.Presumably,therapeutic resistance of pancreatic cancer is at least in part due to its drastic desmoplasis,which is a defining hallmark for and circumstantially contributes to pancreatic cancer development and progression.Improved understanding of the dynamic interaction between cancer cells and the stroma is important to better understanding pancreatic cancer biology and to designing effective intervention strategies.This review focuses on the origination,evolution and disruption of stromal molecular and cellular components in pancreatic cancer,and their biological effects on pancreatic cancer pathogenesis.展开更多
基金National Natural Science Foundation of China(82072632)Guangzhou Municipality Bureau of Science and Technology,Guangzhou,China(202102010033)Natural Science Foundation of Guangdong Province,China(2022A1515012585).
文摘Pancreatic cancer is one of the deadliest malignancies,with limited effectiveness of standard therapies,resulting in little improvement in the 5-year survival rate over the past few decades.However,advanced radiotherapy techniques and emerging treatment modalities,such as immunotherapy and targeted therapy,are showing tremendous potential as effective treatment options for pancreatic cancer patients who were previously considered incurable.This review summarizes the current advances and challenges in pancreatic cancer treatment strategies and proposes further optimization directions,aiming to provide insights into the cure of incurable pancreatic cancer.
基金The work was supported in part by grants R01-CA129956,R01-CA148954,R01CA152309 and R01CA172233(to K.Xie)from the National Cancer Institute,National Institutes of HealthThis research is supported in part by the National Institutes of Health through MD Anderson’s Cancer Center Support Grant CA016672.
文摘Pancreatic cancer is one of the most lethal malignancies.Significant progresses have been made in understanding of pancreatic cancer pathogenesis,including appreciation of precursor lesions or premalignant pancreatic intraepithelial neoplasia(PanINs),description of sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and identification of major genetic and epigenetic events and the biological impact of those events on malignant behavior.However,the currently used therapeutic strategies targeting tumor epithelial cells,which are potent in cell culture and animal models,have not been successful in the clinic.Presumably,therapeutic resistance of pancreatic cancer is at least in part due to its drastic desmoplasis,which is a defining hallmark for and circumstantially contributes to pancreatic cancer development and progression.Improved understanding of the dynamic interaction between cancer cells and the stroma is important to better understanding pancreatic cancer biology and to designing effective intervention strategies.This review focuses on the origination,evolution and disruption of stromal molecular and cellular components in pancreatic cancer,and their biological effects on pancreatic cancer pathogenesis.
