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1α羟维生素D_(3)对去卵巢大鼠的松质骨和密质骨的影响 被引量:1
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作者 夏维波 孟迅吾 +9 位作者 邢小平 胡莹莹 刘怀成 周学瀛 邱贵兴 杨新宇 Victor Shen dadong wu David Dempster Robert Lindsay 《中国医学科学院学报》 CAS CSCD 北大核心 2000年第6期542-547,共6页
目的探讨 1α (OH)D3对去卵巢( OVX)大鼠密质骨和松质骨的影响。方法将 41只雌性健康 Wistar大鼠分为 5组,于不同时间予以处死。( 1)基线组: 6月龄时处死;( 2)假手术组:施行手术,未切卵巢;( 3) OVXb组: 6月龄切除卵巢, ... 目的探讨 1α (OH)D3对去卵巢( OVX)大鼠密质骨和松质骨的影响。方法将 41只雌性健康 Wistar大鼠分为 5组,于不同时间予以处死。( 1)基线组: 6月龄时处死;( 2)假手术组:施行手术,未切卵巢;( 3) OVXb组: 6月龄切除卵巢, 6周后处死;( 4) OVXe组:切除卵巢后 14周处死;( 5) O+ VD组 :于去卵巢 6周后经胃肠道给予 0.1μ g/(kg· d) 1α (OH)D3,共 8周。( 2)、( 4)和( 5)组均于手术后 14周时处死。对以上各组动物分别进行胫骨近端骨组织计量学、股骨 pQCT、骨生物力学测定和血尿骨转换指标的测定。结果去卵巢后大鼠的骨转换增加,骨小梁破坏,松质骨骨小梁减少,力学特性降低。经 1α (OH)D3治疗组血钙浓度有轻度升高,尿脱氧吡啶啉 /肌酐比率较未治疗组降低 67.0% [(43.50± 11.20)nmol· L- 1/mmol· L- 1vs(131.80± 14.90)nmol· L- 1/mmol· L- 1, P< 0.01],骨小梁的面积( 11.03± 0.73)比 OVXe组( 5.81± 1.29)增加 89.8%( P< 0.05)。股骨远端松质骨骨量和骨密度分别比 OVXe组增加 77.3%和 91.3%( P< 0.05)。 OVX和 1α (OH)D3均未引起密质骨骨量、面积和厚度的显著变化,而主要是表现为增龄性积累现象。 O+ VD组的股骨密质骨的极性截面惯性矩 (PMI)? 展开更多
关键词 1α羟维生素D_(3) 去卵巢大鼠 骨质疏松症
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Implementing the free HPV vaccination for adolescent girls aged below 14 in Shenzhen,Guangdong Province of China:experience,challenges,and lessons 被引量:2
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作者 dadong wu Peiyi Liu +6 位作者 Danhong Song He Wang Siqi Chen Wanyi Tang Xuelian Zhao Fanghui Zhao Yueyun Wang 《Infectious Diseases of Poverty》 SCIE CAS CSCD 2023年第5期94-94,共1页
Cervical cancer is a major public health concern in China,accounting for almost one-fifth of the global incidence and mortality.The recently prequalified domestic bivalent human papillomavirus(HPV)vaccine offers a pra... Cervical cancer is a major public health concern in China,accounting for almost one-fifth of the global incidence and mortality.The recently prequalified domestic bivalent human papillomavirus(HPV)vaccine offers a practical and feasible preventive measure.In response to the global call for action,the National Health Commission issued an Action Plan to eliminate cervical cancer by 2030,with promotion of the HPV vaccination for school-aged girls as a critical step.Despite this,implementation of the vaccination has been patchy,with very low coverage among eligible girls.To address this,from December 2021 to December 2022,a demonstration project was launched in Shenzhen,Guangdong Province,to promote the inclusion of HPV vaccine in local immunisation programme and to address existing barriers to implementation.Using multiple sources of data,this article presents a case study of the demonstration project,analysing its impact on rolling out HPV vaccination among eligible girls and identifying any challenges encountered during implementation.The demonstration project has shown promising results in increasing the HPV vaccination rate,promoting public awareness and acceptance of the domestic HPV vaccine,and establishing a model for quickly scaling up the vaccination at the municipal level.The success of the project can be attributed to several factors,including strong governmental commitment,sufficient funding,multi-sectoral collaboration,ensured vaccine accessibility and affordability,improved vaccination services,and effective health education and communication strategies.Lessons learned from Shenzhen can provide valuable insights for future advocacy and implementation of the vaccination in other areas of China,but challenges must be addressed to achieve universal coverage.These include addressing vaccine hesitancy,expanding the programme to cover a broader age range,and ensuring consistent quality of vaccination services in primary care facilities.Overcoming these challenges will require innovative strategies,public-private partnerships,and sustained funding and resources.Future research should focus on evaluating the long-term effectiveness of the vaccination programme and identifying contextual factors that may impact its implementation in different settings.Overall,the effective control of cervical cancer in China will rely on the“political will”to ensure the incorporation of preventive interventions into policies and universal programme coverage. 展开更多
关键词 Cervical cancer Human papillomavirus VACCINATION ADOLESCENT Case study
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