On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dim...On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dimensional S-wave velocity model from ambient noise tomography using data from a newly deployed dense seismic array around the epicenter,by extracting and jointly inverting the Rayleigh phase and group velocities in the period of 1.6–7.2 s.The results showed that the velocity model varied significantly beneath different geological units.The Yujiasi syncline is characterized by low velocity at depths of~3.0–4.0 km,corresponding to the stable sedimentary layer in the Sichuan Basin.The eastern and western branches of the Huayingshan fault belt generally exhibit high velocities in the NE-SW direction,with a few local low-velocity zones.The Luxian MS6.0 earthquake epicenter is located at the boundary between the high-and low-velocity zones,and the earthquake sequences expand eastward from the epicenter at depths of 3.0–5.0 km.Integrated with the velocity variations around the epicenter,distribution of aftershock sequences,and focal mechanism solution,it is speculated that the seismogenic mechanism of the main shock might be interpreted as the reactivation of pre-existing faults by hydraulic fracturing.展开更多
On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again att...On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone.展开更多
The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unkno...The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury.展开更多
基金This work was supported by the Special Fund of the Institute of Geophysics,China Earthquake Administration(Nos.DQJB22B19,DQJB22R29 and DQJB22B26)the National Natural Science Foundation of China(Nos.41974066,U1839209 and 42074053)。
文摘On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dimensional S-wave velocity model from ambient noise tomography using data from a newly deployed dense seismic array around the epicenter,by extracting and jointly inverting the Rayleigh phase and group velocities in the period of 1.6–7.2 s.The results showed that the velocity model varied significantly beneath different geological units.The Yujiasi syncline is characterized by low velocity at depths of~3.0–4.0 km,corresponding to the stable sedimentary layer in the Sichuan Basin.The eastern and western branches of the Huayingshan fault belt generally exhibit high velocities in the NE-SW direction,with a few local low-velocity zones.The Luxian MS6.0 earthquake epicenter is located at the boundary between the high-and low-velocity zones,and the earthquake sequences expand eastward from the epicenter at depths of 3.0–5.0 km.Integrated with the velocity variations around the epicenter,distribution of aftershock sequences,and focal mechanism solution,it is speculated that the seismogenic mechanism of the main shock might be interpreted as the reactivation of pre-existing faults by hydraulic fracturing.
基金This research was supported by the National Natural Science Foundation of China(No.41974066,No.41474057)ChinArray Project-Northern Section of South-North Seismic Belt(201308011)+1 种基金Project of Science for Earthquake Resilience(XH20051)the Science and Technology Innovation Fund of Sichuan Earthquake Administration(201804).
文摘On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone.
基金supported by the National Natural Science Foundation of China(31401000 and 81430044)the Youth Medicine Program of the People’s Liberation Army of China(13QNP148)+1 种基金the National Basic Research Development Program(973 Program)of China(2012CB518200)the Integrated Drug Discovery Technology Platform of National Science and Technology Major Projects for‘‘Major New Drugs Innovation and Development’’,China(2012ZX09J12201-005)
文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury.