The most frequently encountered non-pigmented tumor of the ocular surface is ocular surface squamous neoplasia(OSSN).Over the past two decades,the pharmacological management of OSSN has grown,with topical 5-fluorourac...The most frequently encountered non-pigmented tumor of the ocular surface is ocular surface squamous neoplasia(OSSN).Over the past two decades,the pharmacological management of OSSN has grown,with topical 5-fluorouracil,mitomycin,and interferon alpha 2b all being successfully used to treat this disease.Other agents,such as anti-vascular endothelial growth factor(VEGF),retinoic acid,cidofovir and Aloe vera,have less frequently been used in the treatment of OSSN.This review will discuss these pharmacologic agents,summarizing available data and presenting the approach to the treatment of these tumors.展开更多
基金Supported by the Department of Veterans Affairs,Veterans Health Administration,Office of Research and Development,Clinical Sciences Research EPID-006-15S(Dr.Galor)R01EY026174(Dr.Galor)+7 种基金NIH Center Core Grant P30EY014801Research to Prevent Blindness,Unrestricted Grant(Dr.Galor)the Ronald and Alicia Lepke Grant,the Lee and Claire Hager Grant,the Elaine and Robert Baer Grantthe H.Scott Huizenga Grantthe Emilyn Page and Mark Feldberg Grant,the Jose Ferreira de Melo Grantthe Michele and Ted Kaplan Grantthe Kathy and Richard Lesser Grantthe Azar Family Grant(institutional grants).
文摘The most frequently encountered non-pigmented tumor of the ocular surface is ocular surface squamous neoplasia(OSSN).Over the past two decades,the pharmacological management of OSSN has grown,with topical 5-fluorouracil,mitomycin,and interferon alpha 2b all being successfully used to treat this disease.Other agents,such as anti-vascular endothelial growth factor(VEGF),retinoic acid,cidofovir and Aloe vera,have less frequently been used in the treatment of OSSN.This review will discuss these pharmacologic agents,summarizing available data and presenting the approach to the treatment of these tumors.
