Pulmonary protozoal infections are rare. A 28-year-old woman was admitted to hospital with chief complains of cough, sputum, and dyspnea. The clinical laboratory tests for blood revealed an increased eosinophil percen...Pulmonary protozoal infections are rare. A 28-year-old woman was admitted to hospital with chief complains of cough, sputum, and dyspnea. The clinical laboratory tests for blood revealed an increased eosinophil percentage of 31.3%and significantly elevated total IgE. The chest computed tomography scan revealed that bilateral bronchial walls were thickening, accompanied with patchy spots scattered throughout bilateral lungs. A suspected multiflagellated protozoan was observed under a light microscope. But some different features were observed by electron microscopy, such as the orientation of flagella and nucleus. Besides, both bronchoalveolar lavage fluid and bronchoscopic brush smears underwent Gram staining and Pap staining, which revealed that numerous respiratory ciliated cells were scattered or accumulated in the sample.Finally, she was diagnosed with eosinophil pneumonia. Metronidazole,bronchodilators, and mucolytics were taken for 5 d and symptoms and pulmonary ventilation function improved. We herein report a case of chronic eosinophilic pneumonia, which was misdiagnosed as multiflagellated protozoan infection, and it is suggested that reliable diagnosis approaches are necessary,rather than clinical symptoms and morphological features.展开更多
The red giant branch(RGB)of globular clusters(GCs)is home to some exotic stars,which may provide clues on the formation of multiple stellar populations in GCs.It is well known that binary interactions are responsible ...The red giant branch(RGB)of globular clusters(GCs)is home to some exotic stars,which may provide clues on the formation of multiple stellar populations in GCs.It is well known that binary interactions are responsible for many exotic stars.Thus,it is important to understand what fraction of stars on the RGB of GCs is the result of binary interactions.In this paper,we performed a binary population synthesis study to track the number of post-binary-interaction(post-BI)stars that appear on the RGB,with particular emphasis on the evolved blue straggler stars(E-BSSs).Assuming an initial binary fraction of nearly 50%,we find that about half of the objects on the RGB(called giants)underwent the binary interactions,and that E-BSSs account for around 10%of the giants in our standard simulation.We also compare the properties of post-BI giants that evolved from different channels.We find that the initial orbital period and mass ratio distributions significantly affect the fraction of post-BI giants.Our results imply that the non-standard stars from binary interactions provide a non-negligible contribution to the RGB stars in GCs,which should be considered in future investigations of the origin of multiple stellar populations.展开更多
Bloodstream infections(BSIs)have emerged as a worldwide concern because of their increasing incidence,mortality,and associated healthcare cost.Strains in ESKAPE including Enterococcus faecium(E.faecium),Staphylococcus...Bloodstream infections(BSIs)have emerged as a worldwide concern because of their increasing incidence,mortality,and associated healthcare cost.Strains in ESKAPE including Enterococcus faecium(E.faecium),Staphylococcus aureus(S.aureus),Klebsiella pneumonia(K.pneumonia),Acinetobacter baumannii(A.baumannii),Pseudomonas aeruginosa(P.aeruginosa),and Enterobacter spp.,as well as Escherichia coli(E.coli),account for more than half of the causative pathogens of BSI.[1]Moreover,the incidences and resistance rates of ESKAPE and E.coli have changed in recent years.A study in Rome found that E.coli,followed by S.aureus,was the most frequently identified microorganism;further,the study revealed that,regardless of hospital or community-onset,the number of extended-spectrumβ-lactamases-producing E.coli was increasing,and carbapenemase-producing K.pneumoniae had become more prevalent during the study period.[1]A recent study suggested upward resistance trends of ESKAPE and E.coli organisms isolated from blood cultures from 2014 to 2018 in a hospital in Italy.[2]The frequencies and resistance rates of ESKAPE and E.coli are most likely interrelated with the spectrum of disease,geographical situation,antimicrobial management,and hand hygiene.Since 2012,some requirements have been gradually executed according to the Measures for the Administration of Clinical Application of Antibiotics(Decree No.84 of the Ministry of Health),the Guidelines for Clinical Application of Antibiotics(2015 edition),and the Notice on Continuous Management of Clinical Application of Antibiotics(General Office of the National Health Commission,2018)at our hospital.However,it is unclear whether these measures are effective to minimize the antibiotic resistance rate.This study investigated the resistance rates and antimicrobial resistance indexes(ARIs)of ESKAPE and E.coli isolated from blood samples at our hospital,and aimed to contribute to the research on ESKAPE and E.coli in China as well as the availability of methods for antibiotic administration.展开更多
基金Supported by the National Natural Science Foundation of China,No.81500430 and No.U1304802the Science and Technology Planning Project of Henan Province,No.182102310567,No.182102310544,and No.182102310566+1 种基金the Henan Medical Science and Technology Tackling Project,No.201702136Key Project of Science and Technology Research of Education Department of Henan Province,No.17A320019
文摘Pulmonary protozoal infections are rare. A 28-year-old woman was admitted to hospital with chief complains of cough, sputum, and dyspnea. The clinical laboratory tests for blood revealed an increased eosinophil percentage of 31.3%and significantly elevated total IgE. The chest computed tomography scan revealed that bilateral bronchial walls were thickening, accompanied with patchy spots scattered throughout bilateral lungs. A suspected multiflagellated protozoan was observed under a light microscope. But some different features were observed by electron microscopy, such as the orientation of flagella and nucleus. Besides, both bronchoalveolar lavage fluid and bronchoscopic brush smears underwent Gram staining and Pap staining, which revealed that numerous respiratory ciliated cells were scattered or accumulated in the sample.Finally, she was diagnosed with eosinophil pneumonia. Metronidazole,bronchodilators, and mucolytics were taken for 5 d and symptoms and pulmonary ventilation function improved. We herein report a case of chronic eosinophilic pneumonia, which was misdiagnosed as multiflagellated protozoan infection, and it is suggested that reliable diagnosis approaches are necessary,rather than clinical symptoms and morphological features.
基金the National Natural Science Foundation of China(Grant Nos.12073070,11733008,11873085,11521303,12073071,11873016,11903075,12003027 and 11973081)the Natural Science Foundation of Yunnan Province(Nos.2017HC018,202001AT070058 and 202001AU070054)+8 种基金Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant Nos.2018076 and 2012048)the Chinese Academy of Sciences(CASKJZDEW-M06-01)for supportsupported by CAS‘Light of West China’Programsupported by the National Key Basic R&D Program of China(2019YFA0405500)the LAMOST Fellow project,funded by China Postdoctoral Science Foundation(Grant Nos.2019M653504 and 2020T130563)Yunnan province postdoctoral Directed culture Foundationthe Cultivation Project for LAMOST Scientific Payoff and Research Achievement of CAMS-CASthe science research grants from the China Manned Space Project(No.CMS-CSST-2021-A08)。
文摘The red giant branch(RGB)of globular clusters(GCs)is home to some exotic stars,which may provide clues on the formation of multiple stellar populations in GCs.It is well known that binary interactions are responsible for many exotic stars.Thus,it is important to understand what fraction of stars on the RGB of GCs is the result of binary interactions.In this paper,we performed a binary population synthesis study to track the number of post-binary-interaction(post-BI)stars that appear on the RGB,with particular emphasis on the evolved blue straggler stars(E-BSSs).Assuming an initial binary fraction of nearly 50%,we find that about half of the objects on the RGB(called giants)underwent the binary interactions,and that E-BSSs account for around 10%of the giants in our standard simulation.We also compare the properties of post-BI giants that evolved from different channels.We find that the initial orbital period and mass ratio distributions significantly affect the fraction of post-BI giants.Our results imply that the non-standard stars from binary interactions provide a non-negligible contribution to the RGB stars in GCs,which should be considered in future investigations of the origin of multiple stellar populations.
文摘Bloodstream infections(BSIs)have emerged as a worldwide concern because of their increasing incidence,mortality,and associated healthcare cost.Strains in ESKAPE including Enterococcus faecium(E.faecium),Staphylococcus aureus(S.aureus),Klebsiella pneumonia(K.pneumonia),Acinetobacter baumannii(A.baumannii),Pseudomonas aeruginosa(P.aeruginosa),and Enterobacter spp.,as well as Escherichia coli(E.coli),account for more than half of the causative pathogens of BSI.[1]Moreover,the incidences and resistance rates of ESKAPE and E.coli have changed in recent years.A study in Rome found that E.coli,followed by S.aureus,was the most frequently identified microorganism;further,the study revealed that,regardless of hospital or community-onset,the number of extended-spectrumβ-lactamases-producing E.coli was increasing,and carbapenemase-producing K.pneumoniae had become more prevalent during the study period.[1]A recent study suggested upward resistance trends of ESKAPE and E.coli organisms isolated from blood cultures from 2014 to 2018 in a hospital in Italy.[2]The frequencies and resistance rates of ESKAPE and E.coli are most likely interrelated with the spectrum of disease,geographical situation,antimicrobial management,and hand hygiene.Since 2012,some requirements have been gradually executed according to the Measures for the Administration of Clinical Application of Antibiotics(Decree No.84 of the Ministry of Health),the Guidelines for Clinical Application of Antibiotics(2015 edition),and the Notice on Continuous Management of Clinical Application of Antibiotics(General Office of the National Health Commission,2018)at our hospital.However,it is unclear whether these measures are effective to minimize the antibiotic resistance rate.This study investigated the resistance rates and antimicrobial resistance indexes(ARIs)of ESKAPE and E.coli isolated from blood samples at our hospital,and aimed to contribute to the research on ESKAPE and E.coli in China as well as the availability of methods for antibiotic administration.
