BACKGROUND Radical surgery is a common treatment for patients with gastric cancer;however,it can lead to postoperative complications and intestinal barrier dysfunction.Ultrasound-guided quadratus lumborum block is oft...BACKGROUND Radical surgery is a common treatment for patients with gastric cancer;however,it can lead to postoperative complications and intestinal barrier dysfunction.Ultrasound-guided quadratus lumborum block is often used for postoperative analgesia,but its effects on stress response and intestinal barrier function are not well understood.AIM To investigate the effects of an ultrasound-guided quadratus lumborum block on stress response and intestinal barrier function in patients undergoing radical surgery for gastric cancer.METHODS A total of 100 patients undergoing radical surgery for gastric cancer were randomly categorized into observation and control groups.Plasma adrenaline and cortisol levels,intestinal mucosal barrier indexes,and complication rates were compared between the two groups before,during,and 1 day after surgery.RESULTS The observation group had significantly lower plasma adrenaline and cortisol levels during surgery and at 1 day postoperatively than that of the control group(P<0.05).Additionally,intestinal barrier indexes(endotoxin and D-dimer)at 1 day postoperatively were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION Ultrasound-guided quadratus lumborum block could reduce stress response,protect intestinal barrier function,and decrease the incidence of complications in patients undergoing radical surgery for gastric cancer.This technique has the potential for clinical applications.展开更多
A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have examined whether nitration is also critical for diabetic pe...A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have examined whether nitration is also critical for diabetic peripheral neuropathy. Therefore, this study investigated the effects of high glucose on proliferation, apoptosis, and 3-nitrotyrosine levels of Schwann cells treated with butylphthalide. In addition, we explored potential protective mechanisms of butylphthalide on peripheral nerves. Schwann cells were cultured in vitro with high glucose then stimulated with the peroxynitrite anion inhibitors uric acid and 3-n-butylphthalide for 48 hours. Cell Counting Kit-8 and flow cytometry were used to investigate the effects of uric acid and 3-n-butylphthalide on proliferation and apoptosis of Schwann cells exposed to a high glucose environment. Effects of uric acid and 3-n-butylphthalide on levels of 3-nitrotyrosine in Schwann cells were detected by enzyme-linked immunosorbent assay. The results indicated that Schwann cells cultured in high glucose showed decreased proliferation, but increased apoptosis and intracellular 3-nitrotyrosine levels. However, intervention with uric acid or 3-n-butylphthalide could increase proliferation of Schwann cells cultured in high glucose, and inhibited apoptosis and intracellular 3-nitrotyrosine levels. According to our data, 3-n-butylphthalide may inhibit cell nitrification and apoptosis, and promote cell proliferation, thereby reducing damage to Schwann cells caused by high glucose.展开更多
Quantitative assessment of the impact of groundwater depletion on phreatophytes in(hyper-)arid regions is key to sustainable groundwater management.However,a parsimonious model for predicting the response of phreatoph...Quantitative assessment of the impact of groundwater depletion on phreatophytes in(hyper-)arid regions is key to sustainable groundwater management.However,a parsimonious model for predicting the response of phreatophytes to a decrease of the water table is lacking.A variable saturated flow model,HYDRUS-1D,was used to numerically assess the influences of depth to the water table(DWT)and mean annual precipitation(MAP)on transpiration of groundwater-dependent vegetation in(hyper-)arid regions of northwest China.An exponential relationship is found for the normalized transpiration(a ratio of transpiration at a certain DWT to transpiration at 1 m depth,T_(a)^(*))with increasing DWT,while a positive linear relationship is identified between T_(a)^(*)and annual precipitation.Sensitivity analysis shows that the model is insensitive to parameters,such as saturated soil hydraulic conductivity and water stress parameters,indicated by an insignificant variation(less than 20%in most cases)under±50%changes of these parameters.Based on these two relationships,a universal model has been developed to predict the response of phreatophyte transpiration to groundwater drawdown for(hyper-)arid regions using MAP only.The estimated T_(a)^(*)from the model is reasonable by comparing with published measured values.展开更多
From Rybicki’s analysis using the Fourier slice theorem,mathematically it is possible to reproduce uniquely an edge-on axisymmetric galaxy’s 3D light distribution from its 2D surface brightness.Utilizing galaxies fr...From Rybicki’s analysis using the Fourier slice theorem,mathematically it is possible to reproduce uniquely an edge-on axisymmetric galaxy’s 3D light distribution from its 2D surface brightness.Utilizing galaxies from a cosmological simulation,we examine the ability of Syer and Tremaine’s madeto-measure method and Schwarzschild’s method for stellar dynamical modeling to do so for edge-on oblate axisymmetric galaxies.Overall,we find that the methods do not accurately recover the 3D distributions,with the made-to-measure method producing more accurate estimates than Schwarzschild’s method.Our results have implications broader than just luminosity density,and affect other luminosity-weighted distributions within galaxies,for example,age and metallicity.展开更多
文摘BACKGROUND Radical surgery is a common treatment for patients with gastric cancer;however,it can lead to postoperative complications and intestinal barrier dysfunction.Ultrasound-guided quadratus lumborum block is often used for postoperative analgesia,but its effects on stress response and intestinal barrier function are not well understood.AIM To investigate the effects of an ultrasound-guided quadratus lumborum block on stress response and intestinal barrier function in patients undergoing radical surgery for gastric cancer.METHODS A total of 100 patients undergoing radical surgery for gastric cancer were randomly categorized into observation and control groups.Plasma adrenaline and cortisol levels,intestinal mucosal barrier indexes,and complication rates were compared between the two groups before,during,and 1 day after surgery.RESULTS The observation group had significantly lower plasma adrenaline and cortisol levels during surgery and at 1 day postoperatively than that of the control group(P<0.05).Additionally,intestinal barrier indexes(endotoxin and D-dimer)at 1 day postoperatively were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION Ultrasound-guided quadratus lumborum block could reduce stress response,protect intestinal barrier function,and decrease the incidence of complications in patients undergoing radical surgery for gastric cancer.This technique has the potential for clinical applications.
基金supported by the Natural Science Foundation of Anhui Province,China,No.1608085MH209(to YBW)New Medicine of University of Science and Techology of China,No.WK110000036(to YBW)
文摘A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have examined whether nitration is also critical for diabetic peripheral neuropathy. Therefore, this study investigated the effects of high glucose on proliferation, apoptosis, and 3-nitrotyrosine levels of Schwann cells treated with butylphthalide. In addition, we explored potential protective mechanisms of butylphthalide on peripheral nerves. Schwann cells were cultured in vitro with high glucose then stimulated with the peroxynitrite anion inhibitors uric acid and 3-n-butylphthalide for 48 hours. Cell Counting Kit-8 and flow cytometry were used to investigate the effects of uric acid and 3-n-butylphthalide on proliferation and apoptosis of Schwann cells exposed to a high glucose environment. Effects of uric acid and 3-n-butylphthalide on levels of 3-nitrotyrosine in Schwann cells were detected by enzyme-linked immunosorbent assay. The results indicated that Schwann cells cultured in high glucose showed decreased proliferation, but increased apoptosis and intracellular 3-nitrotyrosine levels. However, intervention with uric acid or 3-n-butylphthalide could increase proliferation of Schwann cells cultured in high glucose, and inhibited apoptosis and intracellular 3-nitrotyrosine levels. According to our data, 3-n-butylphthalide may inhibit cell nitrification and apoptosis, and promote cell proliferation, thereby reducing damage to Schwann cells caused by high glucose.
基金This research was funded by projects of the China Geological Survey(12120113104100 and DD20190351)National Natural Science Foundation of China(41877199)Shaanxi Science and Technology Department(2019TD-040,2021ZDLSF05-01).
文摘Quantitative assessment of the impact of groundwater depletion on phreatophytes in(hyper-)arid regions is key to sustainable groundwater management.However,a parsimonious model for predicting the response of phreatophytes to a decrease of the water table is lacking.A variable saturated flow model,HYDRUS-1D,was used to numerically assess the influences of depth to the water table(DWT)and mean annual precipitation(MAP)on transpiration of groundwater-dependent vegetation in(hyper-)arid regions of northwest China.An exponential relationship is found for the normalized transpiration(a ratio of transpiration at a certain DWT to transpiration at 1 m depth,T_(a)^(*))with increasing DWT,while a positive linear relationship is identified between T_(a)^(*)and annual precipitation.Sensitivity analysis shows that the model is insensitive to parameters,such as saturated soil hydraulic conductivity and water stress parameters,indicated by an insignificant variation(less than 20%in most cases)under±50%changes of these parameters.Based on these two relationships,a universal model has been developed to predict the response of phreatophyte transpiration to groundwater drawdown for(hyper-)arid regions using MAP only.The estimated T_(a)^(*)from the model is reasonable by comparing with published measured values.
基金partly supported by the National Key Basic Research and Development Program of China(No.2018YFA0404501 to Shude Mao)the National Natural Science Foundation of China(NSFC,Grant Nos.11821303,11761131004 and 11761141012 to Shude Mao)。
文摘From Rybicki’s analysis using the Fourier slice theorem,mathematically it is possible to reproduce uniquely an edge-on axisymmetric galaxy’s 3D light distribution from its 2D surface brightness.Utilizing galaxies from a cosmological simulation,we examine the ability of Syer and Tremaine’s madeto-measure method and Schwarzschild’s method for stellar dynamical modeling to do so for edge-on oblate axisymmetric galaxies.Overall,we find that the methods do not accurately recover the 3D distributions,with the made-to-measure method producing more accurate estimates than Schwarzschild’s method.Our results have implications broader than just luminosity density,and affect other luminosity-weighted distributions within galaxies,for example,age and metallicity.
