Rechargeable lithium-sulfur(Li-S)batteries are considered one of the most promising energy storage techniques owing to the high theoretical energy density.However,challenges still remain such as the shuttle effect of ...Rechargeable lithium-sulfur(Li-S)batteries are considered one of the most promising energy storage techniques owing to the high theoretical energy density.However,challenges still remain such as the shuttle effect of lithium polysulfides(LPSs)and the instability of lithium metal anode.Herein,we propose to use nitrogen-rich azoles,i.e.,triazole(Ta)and tetrazole(Tta),as trifunctional electrolyte additives for Li-S batteries.The azoles afford strong lithiophilicity for the chemisorption of LPSs.The density functional theory and experimental analysis verify the presence of Li bonds between the azoles and LPSs.The azoles can also interact with lithium salt in the electrolyte,leading to increase ionic conductivity and lithiumion transference number.Moreover,the azoles render particle-like lithium deposition on the lithium metal anode,leading to superlong cycling of a Li symmetric cell.The Li-S batteries with Ta and Tta exhibit the initial discharge capacity of 1425.5 and 1322.2 m Ah g^(-1),respectively,at 0.2 C rate,and promising cycling stability.They also enable enhanced cycling performance of a Li-organosulfide battery.展开更多
Objective: To investigate the azole susceptibility of Candida albicans(C.albicans)from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole resistan...Objective: To investigate the azole susceptibility of Candida albicans(C.albicans)from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole resistance.Methods: Three hundred and two clinical isolates of Candida species were collected.Azole susceptibility was tested in vitro in microdilution studies. The ERG11 genes of 17 isolates of C. albicans(2 susceptibles, 5 dose-dependent resistants and 10 resistants) were amplified and sequenced.Results: Of the 302 isolates collected, 70.2% were C. albicans, of which 8.5%, 3.8% and4.2% were resistant to fluconazole, itraconazole and voriconazole, respectively. In total,27 missense mutations were detected in ERG11 genes from resistant/susceptible dosedependent isolates. Among them, Y132 H, A114 S, and Y257 H substitutions were most prevalent and were known to cause fluconazole resistance. G464 S and F72 S also have been proved to cause fluconazole resistance. Two novel substitutions(T285A, S457P) in hotspot regions were identified.Conclusions: Twenty seven mutations in the ERG11 gene were identified in azoleresistant C. albicans isolates, which indicated a possible relation with the increase in resistance to azole drugs and the recurrence of vulvovaginal candidosis. The relationship of two novel substitutions(T285A, S457P) with fluconazole resistance needs to be further verified by site-directed mutagenesis.展开更多
AIM: To assess the effects of small incision lenticule extraction(SMILE) surgery on the corneal endothelium at1 d to 1mo postoperatively.·METHODS: A retrospective, observational study was conducted on 47 pati...AIM: To assess the effects of small incision lenticule extraction(SMILE) surgery on the corneal endothelium at1 d to 1mo postoperatively.·METHODS: A retrospective, observational study was conducted on 47 patients(47 eyes) who received SMILE surgery. Patients were grouped according to contact lens wear condition. The corneal endothelium was examined preoperatively and at 1d, 1wk and 1mo postoperatively.The corneal endothelium was analyzed for endothelial cell density(ECD), percentage of hexagonal cells, and coefficient of variation(CV) of cell size.·RESULTS: There were no significant decrease in the ECD, percentage of hexagonal cells or increase in CV at1 d, 1wk and 1mo postoperatively(P 〉0.05). However,there was a small increase of ECD by 2.88% in contact lens wearers(78.26±113.62 cell/mm2, P 〈0.05).· CONCLUSION: SMILE has no significant adverse effects on the corneal ECD and morphology during 1mo follow-up time.展开更多
Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almos...Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almost exclusively in young girls [1,2].Over 95%of RTT patients carry loss-of-function mutations in the X-linked MECP2gene,while the same mutations in males largely lead to infantile death.展开更多
We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(S...We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(SU-TX) that transmits confidential messages to another secondary user(SU-RX) equipped with M(M ≥ 1)antennas where the MRC technique is adopted to improve its received signal-to-noise ratio. Meanwhile, an eavesdropper equipped with N(N ≥ 1) antennas adopts the MRC scheme to overhear the information between SU-TX and SU-RX. SU-TX adopts the underlay strategy to guarantee the service quality of the primary user without spectrum sensing. We derive the closed-form expressions for an exact and asymptotic secrecy outage probability.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.U2004214,21975225,and 51902293)。
文摘Rechargeable lithium-sulfur(Li-S)batteries are considered one of the most promising energy storage techniques owing to the high theoretical energy density.However,challenges still remain such as the shuttle effect of lithium polysulfides(LPSs)and the instability of lithium metal anode.Herein,we propose to use nitrogen-rich azoles,i.e.,triazole(Ta)and tetrazole(Tta),as trifunctional electrolyte additives for Li-S batteries.The azoles afford strong lithiophilicity for the chemisorption of LPSs.The density functional theory and experimental analysis verify the presence of Li bonds between the azoles and LPSs.The azoles can also interact with lithium salt in the electrolyte,leading to increase ionic conductivity and lithiumion transference number.Moreover,the azoles render particle-like lithium deposition on the lithium metal anode,leading to superlong cycling of a Li symmetric cell.The Li-S batteries with Ta and Tta exhibit the initial discharge capacity of 1425.5 and 1322.2 m Ah g^(-1),respectively,at 0.2 C rate,and promising cycling stability.They also enable enhanced cycling performance of a Li-organosulfide battery.
基金Supported by the National Natural Science Foundation of China(No.31072125 and 31272549)by a National Science and Technology Project (China) grant (2008ZX-10004-011)
文摘Objective: To investigate the azole susceptibility of Candida albicans(C.albicans)from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole resistance.Methods: Three hundred and two clinical isolates of Candida species were collected.Azole susceptibility was tested in vitro in microdilution studies. The ERG11 genes of 17 isolates of C. albicans(2 susceptibles, 5 dose-dependent resistants and 10 resistants) were amplified and sequenced.Results: Of the 302 isolates collected, 70.2% were C. albicans, of which 8.5%, 3.8% and4.2% were resistant to fluconazole, itraconazole and voriconazole, respectively. In total,27 missense mutations were detected in ERG11 genes from resistant/susceptible dosedependent isolates. Among them, Y132 H, A114 S, and Y257 H substitutions were most prevalent and were known to cause fluconazole resistance. G464 S and F72 S also have been proved to cause fluconazole resistance. Two novel substitutions(T285A, S457P) in hotspot regions were identified.Conclusions: Twenty seven mutations in the ERG11 gene were identified in azoleresistant C. albicans isolates, which indicated a possible relation with the increase in resistance to azole drugs and the recurrence of vulvovaginal candidosis. The relationship of two novel substitutions(T285A, S457P) with fluconazole resistance needs to be further verified by site-directed mutagenesis.
基金Supported by the National Natural Science Foundation of China(No.81261130021)Henry G Leong Endowed Professorship fund,PolyU research grant GUA32 for supporting the analysis work in Hong Kong
文摘AIM: To assess the effects of small incision lenticule extraction(SMILE) surgery on the corneal endothelium at1 d to 1mo postoperatively.·METHODS: A retrospective, observational study was conducted on 47 patients(47 eyes) who received SMILE surgery. Patients were grouped according to contact lens wear condition. The corneal endothelium was examined preoperatively and at 1d, 1wk and 1mo postoperatively.The corneal endothelium was analyzed for endothelial cell density(ECD), percentage of hexagonal cells, and coefficient of variation(CV) of cell size.·RESULTS: There were no significant decrease in the ECD, percentage of hexagonal cells or increase in CV at1 d, 1wk and 1mo postoperatively(P 〉0.05). However,there was a small increase of ECD by 2.88% in contact lens wearers(78.26±113.62 cell/mm2, P 〈0.05).· CONCLUSION: SMILE has no significant adverse effects on the corneal ECD and morphology during 1mo follow-up time.
文摘Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almost exclusively in young girls [1,2].Over 95%of RTT patients carry loss-of-function mutations in the X-linked MECP2gene,while the same mutations in males largely lead to infantile death.
基金Project supported in part by the National Natural Science Foundation of China(Nos.61401372 and 61531016)the Research Fund for the Doctoral Program of Higher Education of China(No.20130182120017)+1 种基金the Natural Science Foundation of CQ CSTC(No.cstc2013jcyj A40040)the Fundamental Research Funds for the Central Universities,China(No.XDJK2015B023)
文摘We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(SU-TX) that transmits confidential messages to another secondary user(SU-RX) equipped with M(M ≥ 1)antennas where the MRC technique is adopted to improve its received signal-to-noise ratio. Meanwhile, an eavesdropper equipped with N(N ≥ 1) antennas adopts the MRC scheme to overhear the information between SU-TX and SU-RX. SU-TX adopts the underlay strategy to guarantee the service quality of the primary user without spectrum sensing. We derive the closed-form expressions for an exact and asymptotic secrecy outage probability.