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Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma 被引量:2
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作者 danfeng cao Jie Yang +7 位作者 Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第9期3206-3209,共4页
Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(... Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. 展开更多
关键词 METABOLISM MELANOMA Cancer
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