In recent years,the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the di...In recent years,the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the diverse synthesis of important S-containing derivatives.These 1,n-thiosulfonylation reactions usually feature simple procedures,100%atom economy,and high regioselectivity.This review focuses on the recent advancements in the transformations of thiosulfonates through 1,n-thiosulfonylation involving the formation of two distinct C-S bonds under transition-metal-catalyzed or metal-free conditions,where thiosulfonates act as both a sulfonyl and a sulfenyl component.展开更多
This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroam...This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide derivatives.The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.展开更多
Different from the conventional synthesis methods and substrates, we designed a brand new method for synthesizing amides with platinum nanowires as catalysts and tert-butylhydroperoxide(TBHP) as the oxidant. Influence...Different from the conventional synthesis methods and substrates, we designed a brand new method for synthesizing amides with platinum nanowires as catalysts and tert-butylhydroperoxide(TBHP) as the oxidant. Influence of factors, such as the catalyst, solvents, and the reaction temperature, were studied to determine the optimal reaction conditions. In addition, we explored the substrate generality and observed excellent yields.展开更多
基金financial support from the Natural Science Foundation of China(No.22001121)Natural Science Foundation of Jiangsu Province(No.BK20180690)+1 种基金Nanjing Tech University(Start-up Grant Nos.39837118 and39837146)Xuzhou Medical University(Start-up Grant No.RC20552038)。
文摘In recent years,the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the diverse synthesis of important S-containing derivatives.These 1,n-thiosulfonylation reactions usually feature simple procedures,100%atom economy,and high regioselectivity.This review focuses on the recent advancements in the transformations of thiosulfonates through 1,n-thiosulfonylation involving the formation of two distinct C-S bonds under transition-metal-catalyzed or metal-free conditions,where thiosulfonates act as both a sulfonyl and a sulfenyl component.
基金We gratefully acknowledge the financial support from the Start-up Grant in Nanjing Tech University(Nos.39837118,39837146)the National Natural Science Foundation of China(No.22001121).
文摘This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide derivatives.The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.
基金supported by the National Natural Science Foundation of China (21373006, 51402203)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Different from the conventional synthesis methods and substrates, we designed a brand new method for synthesizing amides with platinum nanowires as catalysts and tert-butylhydroperoxide(TBHP) as the oxidant. Influence of factors, such as the catalyst, solvents, and the reaction temperature, were studied to determine the optimal reaction conditions. In addition, we explored the substrate generality and observed excellent yields.
