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Immunohistochemical Evaluation of Vascular Endothelial Growth Factor(VEGF)in Splenic Hemangiomas and Hemangiosarcomas in Dogs
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作者 Andressa Gianotti Campos Juliana Alvares Duarte Bonini Campos +2 位作者 daniel soares sanches Maria Lucia Zaidan Dagli Julia Maria Matera 《Open Journal of Veterinary Medicine》 2012年第4期191-195,共5页
Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to e... Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P < 0.05). These findings suggest the presence of high VEGF levels may be related to the malignant vascular proliferation seen in hemangiosarcomas. 展开更多
关键词 CANINE SPLEEN Angiogenesis HEMANGIOSARCOMA Immunohistochemistry Vascular Endothelial Growth Factor
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