Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brai...Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and stroke.The functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair(Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.展开更多
基金supported by Ministerio de Ciencia e Innovación(Spain),under project No.PID2020-118120RB-I00European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No.813851European Union’s FET-Open program grant agreement,No.9648877(to DT).
文摘Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and stroke.The functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair(Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.
