Prevention and early diagnosis are the best and most effective ways for defeating HIV.There is still no vaccine,but treatments with antiretroviral drugs are now available which,in many cases,allow the infection to bec...Prevention and early diagnosis are the best and most effective ways for defeating HIV.There is still no vaccine,but treatments with antiretroviral drugs are now available which,in many cases,allow the infection to become chronic.However,research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is stopped.In recent years,the presence of virus reserves located in various parts of the body,including the brain,has been hypothesized.The possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied,proposing optimal control strategies.展开更多
In the last decades several epidemic emergencies have been affecting the world,influencing the social relationships,the economics and the habits.In particular,starting in the early 080,the Acquired Immunodeficiency Sy...In the last decades several epidemic emergencies have been affecting the world,influencing the social relationships,the economics and the habits.In particular,starting in the early 080,the Acquired Immunodeficiency Syndrome,AIDS,is representing one of the most worrying sanitary emergency,that has caused up to now more than 25 million of dead patients.The infection is caused by the Human Immunodeficiency Virus,HIV,that may be transmitted by body fluids;therefore with wise behaviours the epidemic spread could rapidly be contained.This sanitary emergency is peculiar for the long incubation time:it can reach even 10 years,a long period in which the individual can unconsciously infect other subjects.The identification of the number of infected unaware people,mandatory to define suitable containment measures,is here obtained by using the extended Kalman filter applied to a noisy model in which,reasonably,only the number of infected diagnosed patients is available.Numerical simulations and real data analysis support the effectiveness of the approach.展开更多
文摘Prevention and early diagnosis are the best and most effective ways for defeating HIV.There is still no vaccine,but treatments with antiretroviral drugs are now available which,in many cases,allow the infection to become chronic.However,research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is stopped.In recent years,the presence of virus reserves located in various parts of the body,including the brain,has been hypothesized.The possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied,proposing optimal control strategies.
文摘In the last decades several epidemic emergencies have been affecting the world,influencing the social relationships,the economics and the habits.In particular,starting in the early 080,the Acquired Immunodeficiency Syndrome,AIDS,is representing one of the most worrying sanitary emergency,that has caused up to now more than 25 million of dead patients.The infection is caused by the Human Immunodeficiency Virus,HIV,that may be transmitted by body fluids;therefore with wise behaviours the epidemic spread could rapidly be contained.This sanitary emergency is peculiar for the long incubation time:it can reach even 10 years,a long period in which the individual can unconsciously infect other subjects.The identification of the number of infected unaware people,mandatory to define suitable containment measures,is here obtained by using the extended Kalman filter applied to a noisy model in which,reasonably,only the number of infected diagnosed patients is available.Numerical simulations and real data analysis support the effectiveness of the approach.
