Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematologi...Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematological malignancies. Tw o cases of mantle cell lymphoma (MCL), one associated with an insect bite-like reaction and the other with a true hypersensitivity to mosquito bites, have pre viously been reported in the English language literature. The pathogenesis of th e skin eruption may be related to the release of different cytokines that also t rigger an IgE elevation and dermal eosinophils. Case report. We describe two add itional cases of MCL associated with an insect bite-like reaction. One patient had been diagnosed with MCL 4.5 years prior to the appearance of the skin erupt ion, and in the other patient the skin symptoms preceded the diagnosis of the MC L by 2 years and led to its diagnosis. Conclusions. Insect bite-like reaction may appear in patients with MCL. It is important to recognize this entity becaus e it may be the presenting sign of MCL.展开更多
文摘Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematological malignancies. Tw o cases of mantle cell lymphoma (MCL), one associated with an insect bite-like reaction and the other with a true hypersensitivity to mosquito bites, have pre viously been reported in the English language literature. The pathogenesis of th e skin eruption may be related to the release of different cytokines that also t rigger an IgE elevation and dermal eosinophils. Case report. We describe two add itional cases of MCL associated with an insect bite-like reaction. One patient had been diagnosed with MCL 4.5 years prior to the appearance of the skin erupt ion, and in the other patient the skin symptoms preceded the diagnosis of the MC L by 2 years and led to its diagnosis. Conclusions. Insect bite-like reaction may appear in patients with MCL. It is important to recognize this entity becaus e it may be the presenting sign of MCL.
