The visible light induced multicomponent reaction of styrene,carbon disulfide,amine and ethyl difluorobromoacetate for the synthesis of thiodifluoroesters is disclosed.This developed protocol offers a facile and gener...The visible light induced multicomponent reaction of styrene,carbon disulfide,amine and ethyl difluorobromoacetate for the synthesis of thiodifluoroesters is disclosed.This developed protocol offers a facile and general route to access various valuable thiodifluoroesters in moderate to good yields.Preliminary mechanistic studies revealed that a radical process might be involved in this transformation.展开更多
Oximes derivatives have been vastly used in organic synthesis. In this review, C(sp^(3))-H bond functionalization of oximes derivatives via iminyl radical induced 1,5-hydrogen atom transfer was discussed. According to...Oximes derivatives have been vastly used in organic synthesis. In this review, C(sp^(3))-H bond functionalization of oximes derivatives via iminyl radical induced 1,5-hydrogen atom transfer was discussed. According to the different type of products, this review was divided into three parts: (1) C(sp^(3))-H bond functionalization for C-C bond formation. (2) C(sp^(3))-H bond functionalization for C-N bond formation. (3) C(sp^(3))-H bond functionalization for C-S, C-F bond formation.展开更多
An efficient and facile method for C-H amination of quinoxalinones with heteroaromatic amines under metal-free conditions has been described.In the presence of hypervalent PIDA reagent,the desired products with variou...An efficient and facile method for C-H amination of quinoxalinones with heteroaromatic amines under metal-free conditions has been described.In the presence of hypervalent PIDA reagent,the desired products with various groups were obtained with moderate to high yields.展开更多
A method of C(sp^3)-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologica...A method of C(sp^3)-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.展开更多
A novel and efficient method for the synthesis of amide has been developed. The reactions proceeded smoothly under aqueous conditions at room temperature and generated the corresponding products in good to excellent y...A novel and efficient method for the synthesis of amide has been developed. The reactions proceeded smoothly under aqueous conditions at room temperature and generated the corresponding products in good to excellent yields. It is worth noting that alkyl amines which did not react in known approaches are well tolerated in our system.展开更多
基金supported by the National Natural Science Foundation of China (21402103, 21772107)the China Postdoctoral Science Foundation (150030)+1 种基金the Research Fund of Qingdao Agricultural University’s Highlevel Person (631303)Shandong province key research and development plan(GG201809130228)~~
基金financial support from National Natural Science Foundation of China(No.21772107)Shandong Province Key Research and Development Plan(No.2019GSF108017)Youth Innovation Team Project for Talent Introduction and Cultivation in Universities of Shandong Province(2021)。
文摘The visible light induced multicomponent reaction of styrene,carbon disulfide,amine and ethyl difluorobromoacetate for the synthesis of thiodifluoroesters is disclosed.This developed protocol offers a facile and general route to access various valuable thiodifluoroesters in moderate to good yields.Preliminary mechanistic studies revealed that a radical process might be involved in this transformation.
基金supported by the National Natural Science Foundation of China (Nos. 21772107, 21901010)Shandong Province Key Research and Development Plan (No. 2019GSF108017)。
文摘Oximes derivatives have been vastly used in organic synthesis. In this review, C(sp^(3))-H bond functionalization of oximes derivatives via iminyl radical induced 1,5-hydrogen atom transfer was discussed. According to the different type of products, this review was divided into three parts: (1) C(sp^(3))-H bond functionalization for C-C bond formation. (2) C(sp^(3))-H bond functionalization for C-N bond formation. (3) C(sp^(3))-H bond functionalization for C-S, C-F bond formation.
基金supported by the National Natural Science Foundation of China (No.21772107)Shandong Province Key Research and Development Plan (No.2019GSF108017)。
文摘An efficient and facile method for C-H amination of quinoxalinones with heteroaromatic amines under metal-free conditions has been described.In the presence of hypervalent PIDA reagent,the desired products with various groups were obtained with moderate to high yields.
基金Financial support from the National Natural Science Foundation of China(No.21402103)the research fund of Qingdao Agricultural University's High-level Person(No.631303)the Scientific Research Foundation of Shandong Province Outstanding Young Scientist Award(No.BS2013YY024) were gratefully acknowledged
文摘A method of C(sp^3)-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.
基金The National Natural Science Foundation of China(No.21402103)the China Postdoctoral Science Foundation(No.150030)+1 种基金the Scientific Research Foundation of Shandong Province Outstanding Young Scientist Award(No.BS2013YY024)the research fund of Qingdao Agricultural University’s High-level Person(No.631303)
文摘A novel and efficient method for the synthesis of amide has been developed. The reactions proceeded smoothly under aqueous conditions at room temperature and generated the corresponding products in good to excellent yields. It is worth noting that alkyl amines which did not react in known approaches are well tolerated in our system.