A new DBU-catalyzed formal[4+2]cycloaddition between ortho-hydroxyphenyl-substituted para-quinone methides and electron-deficient dienophiles including 3-methyleneoxindoles and 2-aryldeneindene-1,3-diones was establis...A new DBU-catalyzed formal[4+2]cycloaddition between ortho-hydroxyphenyl-substituted para-quinone methides and electron-deficient dienophiles including 3-methyleneoxindoles and 2-aryldeneindene-1,3-diones was established.A wide range of functionalized spiro[chromane-3,30-indolines]and spiro[chromane-3,20-indenes]were successfully synthesized in good yields and with high diastereoselectivity.The features of the reaction included readily available substrates,mild reaction conditions,convenient methodology and good functional group tolerance.展开更多
基金We are grateful to the National Natural Science Foundation of China(Nos.21572196,21871227)the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.BK2013016)for financial support.
文摘A new DBU-catalyzed formal[4+2]cycloaddition between ortho-hydroxyphenyl-substituted para-quinone methides and electron-deficient dienophiles including 3-methyleneoxindoles and 2-aryldeneindene-1,3-diones was established.A wide range of functionalized spiro[chromane-3,30-indolines]and spiro[chromane-3,20-indenes]were successfully synthesized in good yields and with high diastereoselectivity.The features of the reaction included readily available substrates,mild reaction conditions,convenient methodology and good functional group tolerance.
