Conventional craniotomy versus conservative treatment in patients with minor spontaneous intracerebral hemorrhage in the basal ganglia

Background:The treatment for spontaneous intracerebral hemorrhage(ICH)is still controversial,especially for hematomas in the basal ganglia.A retrospective case-control study with propensity score matching was performed to compare the outcomes of conventional craniotomy and conservative treatment for patients with minor ICH in the basal ganglia.Methods:We retrospectively collected the data of consecutive patients with minor basal ganglia hemorrhage from January 2018 to August 2019.We compared clinical outcomes of two groups using propensity score matching.The extended Glasgow outcome scale obtained by phone interviews based on questionnaires at a 12-month follow-up was used as the primary outcome measure.According to a previous prognosis algorithm,patients were divided into good and poor prognosis groups to obtain a dichotomized(favorable or unfavorable)outcome as the primary outcome.Secondary outcomes included hospitalized complications,mortality,and modified Rankin score at 12 months.Results:A total of 54 patients were analyzed,and the baseline characteristics of patients in the surgery and conservative treatment groups were well matched.The primary favorable outcome at 12 months was significantly higher in the conservative treatment group than in the surgery group(81%vs 44%;OR 1.833,95%CI 1.159-2.900;P=0.005).The incidence of pneumonia in the surgery group was significantly higher than that in the conservative treatment group(P=0.005).Conclusions:It is not recommended to undertake conventional craniotomy for patients with a minor hematoma(25-40 ml)in the basal ganglia.An open craniotomy might induce worse long-term functional outcomes than the conservative treatment.

Tandem cyclization/arylation of diaryliodoniums via in situ constructed benzoxazole as a directing group for atom-economical transformation

Linear diaryliodoniums often undergo only single arylation and leave equivalent aryl iodide as waste.Herein,we demonstrate that linear unsymmetrical diaryliodoniums could be tuned by a dual nickel/palla-dium metal system to accomplish one-pot cyclization/arylation.Of note,the in situ generated benzox-azole motifs could then be utilized as directing groups for subsequent C–H activated arylation from the often unwanted aryl iodide,exhibiting good reactions with atom economy and regioselectivity.