Sox2 is a key transfer factor for maintaining pluripotency and self-renewal in embryonic stem cells(ESCs),1 though the mechanism of its transcriptional regulation in ESCs has not been fully addressed.Distal enhancer-p...Sox2 is a key transfer factor for maintaining pluripotency and self-renewal in embryonic stem cells(ESCs),1 though the mechanism of its transcriptional regulation in ESCs has not been fully addressed.Distal enhancer-promoter interactions are vital for Sox2 transcription activity in mammals.However,how these diverse interactions individually influence Sox2 gene regulation in mouse ESCs remains unclear.Previous studies found that three distal enhancers(termed E1,E2,and E3)interact with Sox2 promoter?(Fig.1A;Fig.S1A,and Table S1).展开更多
基金supported by the National Key Research and Development Program of China(No.2018YFA0903201)the National Natural Science Foundation of China(No.32202653 and 31970592)+3 种基金the Agricultural Science and Technology Innovation Program(33-AGIS-07)the China Postdoctoral Science Foundation(No.BX2021367 and 2021M703543)the Guangdong Basic and Applied Basic ResearchFoundation(No.2022A1515010766)the Shenzhen Science and Technology Program(No.KCXFZ2020122-1173205015 and RCBS20210609104512021).
文摘Sox2 is a key transfer factor for maintaining pluripotency and self-renewal in embryonic stem cells(ESCs),1 though the mechanism of its transcriptional regulation in ESCs has not been fully addressed.Distal enhancer-promoter interactions are vital for Sox2 transcription activity in mammals.However,how these diverse interactions individually influence Sox2 gene regulation in mouse ESCs remains unclear.Previous studies found that three distal enhancers(termed E1,E2,and E3)interact with Sox2 promoter?(Fig.1A;Fig.S1A,and Table S1).
