The widespread outbreak of SARS-CoV-2 was declared a public health emergency by the World Health Organization and various governments worldwide.This prompted the implementation of stringent infection control measures ...The widespread outbreak of SARS-CoV-2 was declared a public health emergency by the World Health Organization and various governments worldwide.This prompted the implementation of stringent infection control measures to curb the spread of the virus.Amidst this,the medical community faced the challenge of treating the virus without specific therapies or a vaccine,leading to reliance on empirical treatment approaches.In this context,hydroxychloroquine,an antimalarial and antirheumatic drug,gained attention as a potential treatment option.Despite its theoretical benefits,such as inhibiting viral entry,reducing inflammation,and modulating immune responses,empirical studies yielded inconsistent results.Some indicated a potential for symptom relief,while others showed no significant improvement in patient outcomes.The initial enthusiasm waned as the lack of substantial evidence led to revoking its Emergency Use Authorization,and several clinical trials were prematurely halted.The review in question critically examines the factors contributing to the ineffectiveness of hydroxychloroquine in treating SARS-CoV-2 infection,highlighting the complexities of drug repurposing during a rapidly evolving pandemic.展开更多
Objective:To assess the preparedness for handling injuries by female primary school teachers based on their knowledge,attitude,practice and their willingness to learn first aid.Methods:A cross-sectional questionnaire ...Objective:To assess the preparedness for handling injuries by female primary school teachers based on their knowledge,attitude,practice and their willingness to learn first aid.Methods:A cross-sectional questionnaire on first aid was provided to female primary school teachers,and the knowledge,attitude,practice and their willingness to learn first aid were investigated.Data were analyzed using SPSS version 23.Quantitative data were analyzed by one-way ANOVA,categorical variables were analyzed by the Chi-square test.The level of significance was set at P<0.05.Results:In total,464 teachers of different age groups and education responded.The mean knowledge score was low but the mean attitude score was high.Parental consent was sought by one-fourth of the teachers,and 25.6%of teachers documented the health status of children.Most of the teachers desired to have a first aider,and they were keen on training(62.3%)and educating children(88.1%)on first aid.Knowledge scores were significantly impacted by age(P<0.05)and experience(P<0.01),while specialization impacted mean practice scores(P<0.001).Teachers'qualification(P<0.05),first action to be taken at the accident site(P<0.05),and frequency of training(P<0.05),were significantly associated with the need of a first aider.Conclusions:Based on the paucity of awareness and expertise,on priority basis,it is important to strengthen teachers'skills.Child safety is an important public health issue and can be improved by educating and training teachers.展开更多
It is challenging for many drugs to be transported across various biological membranes. Furthermore, development of many drugs gets thwarted owing to their hydrophilic nature. The bioavailability of such drugs, which ...It is challenging for many drugs to be transported across various biological membranes. Furthermore, development of many drugs gets thwarted owing to their hydrophilic nature. The bioavailability of such drugs, which is the function of their ability to cross the membrane, tends to be low and exhibit high intra and inter subject variability. At present, formulation scientists are pursuing many projects for transdermal, nasal, target delivery of many active compounds, and it is prudent to explore alternative possibilities. Cubosomes offer transportation and tailoring of active compounds intended for both systemic and dermal delivery. Cubosomes are dispersed, self-assembled nanoparticles of bicontinuous cubic liquid crystalline phase formed from lipid and surfactant systems. Monoolein, poloxamer 407 and polyvinyl alcohol are the mostly used ingredients in the formulation of cubosomes. The adjustment in lipid composition can control the internal and structural changes of cubosomes. Based on the nodal surfaces, three structures of cubosomes proposed are Pn3m, Ia3d and Im3m. Top-down and bottom-up techniques are widely considered in the formulation process of extreme viscous bulk phase and aggregate from a precursor respectively. This article gives a bird's eye view about the engineering, characterization and evaluation of cubosomes, covering researches and applications of cubosomes done till date.展开更多
文摘The widespread outbreak of SARS-CoV-2 was declared a public health emergency by the World Health Organization and various governments worldwide.This prompted the implementation of stringent infection control measures to curb the spread of the virus.Amidst this,the medical community faced the challenge of treating the virus without specific therapies or a vaccine,leading to reliance on empirical treatment approaches.In this context,hydroxychloroquine,an antimalarial and antirheumatic drug,gained attention as a potential treatment option.Despite its theoretical benefits,such as inhibiting viral entry,reducing inflammation,and modulating immune responses,empirical studies yielded inconsistent results.Some indicated a potential for symptom relief,while others showed no significant improvement in patient outcomes.The initial enthusiasm waned as the lack of substantial evidence led to revoking its Emergency Use Authorization,and several clinical trials were prematurely halted.The review in question critically examines the factors contributing to the ineffectiveness of hydroxychloroquine in treating SARS-CoV-2 infection,highlighting the complexities of drug repurposing during a rapidly evolving pandemic.
文摘Objective:To assess the preparedness for handling injuries by female primary school teachers based on their knowledge,attitude,practice and their willingness to learn first aid.Methods:A cross-sectional questionnaire on first aid was provided to female primary school teachers,and the knowledge,attitude,practice and their willingness to learn first aid were investigated.Data were analyzed using SPSS version 23.Quantitative data were analyzed by one-way ANOVA,categorical variables were analyzed by the Chi-square test.The level of significance was set at P<0.05.Results:In total,464 teachers of different age groups and education responded.The mean knowledge score was low but the mean attitude score was high.Parental consent was sought by one-fourth of the teachers,and 25.6%of teachers documented the health status of children.Most of the teachers desired to have a first aider,and they were keen on training(62.3%)and educating children(88.1%)on first aid.Knowledge scores were significantly impacted by age(P<0.05)and experience(P<0.01),while specialization impacted mean practice scores(P<0.001).Teachers'qualification(P<0.05),first action to be taken at the accident site(P<0.05),and frequency of training(P<0.05),were significantly associated with the need of a first aider.Conclusions:Based on the paucity of awareness and expertise,on priority basis,it is important to strengthen teachers'skills.Child safety is an important public health issue and can be improved by educating and training teachers.
文摘It is challenging for many drugs to be transported across various biological membranes. Furthermore, development of many drugs gets thwarted owing to their hydrophilic nature. The bioavailability of such drugs, which is the function of their ability to cross the membrane, tends to be low and exhibit high intra and inter subject variability. At present, formulation scientists are pursuing many projects for transdermal, nasal, target delivery of many active compounds, and it is prudent to explore alternative possibilities. Cubosomes offer transportation and tailoring of active compounds intended for both systemic and dermal delivery. Cubosomes are dispersed, self-assembled nanoparticles of bicontinuous cubic liquid crystalline phase formed from lipid and surfactant systems. Monoolein, poloxamer 407 and polyvinyl alcohol are the mostly used ingredients in the formulation of cubosomes. The adjustment in lipid composition can control the internal and structural changes of cubosomes. Based on the nodal surfaces, three structures of cubosomes proposed are Pn3m, Ia3d and Im3m. Top-down and bottom-up techniques are widely considered in the formulation process of extreme viscous bulk phase and aggregate from a precursor respectively. This article gives a bird's eye view about the engineering, characterization and evaluation of cubosomes, covering researches and applications of cubosomes done till date.
