Age-related macular degeneration(AMD)has been classified in two groups,neovascular and non-neovascular,which historically has been synonymous with exudative and non-exudative,respectively.Neovascular AMD occurs when p...Age-related macular degeneration(AMD)has been classified in two groups,neovascular and non-neovascular,which historically has been synonymous with exudative and non-exudative,respectively.Neovascular AMD occurs when pathologic blood vessels,choroidal展开更多
The cause of glaucoma,a disease defined by degeneration of retinal ganglion cells associated with cupping of the optic nerve head(ONH)and progressive vision loss,continues to be debated despite numerous advances in op...The cause of glaucoma,a disease defined by degeneration of retinal ganglion cells associated with cupping of the optic nerve head(ONH)and progressive vision loss,continues to be debated despite numerous advances in ophthalmic imaging and diagnostics.Although elevated intraocular pressure is often implicated,many studies,using a variety of imaging techniques including plain fundus photography,fluorescein angiography,laser Doppler flowmetry,and color Doppler ultrasound(1-4),have suggested that insufficiencies of ONH circulation may play a role in glaucoma pathogenesis.While all of these imaging modalities have been informative,each has a set of limitations,including low spatial resolution,invasiveness,restriction to superficial vessels,lack of repeatability,and modality specific artifacts.Optical coherence tomography angiography(OCTA),an imaging technology that can produce high resolution,three-dimensional images of fundus microcirculation,is well suited to overcome many of these limitations(5).展开更多
Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucag...Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucagon-like peptide 1(GLP-1)is of significant clinical interest for the treatment of type-2 diabetes mellitus,but its in vivo instability and short half-life have largely prevented its therapeutic application.Here,we describe the rational design of a series of a/sulfono-γ-AA peptide hybrid analogues of GLP-1 as the GLP-1R agonists.Certain GLP-1 hybrid analogues exhibited enhanced stability(t_(1/2)>14 days)compared to t_(1/2)(<1 day)of GLP-1 in the blood plasma and in vivo.These newly developed peptide hybrids may be viable alternative of semaglutide for type-2 diabetes treatment.Additionally,our findings suggest that sulfono-γ-AA residues could be adopted to substitute canonical amino acids residues to improve the pharmacological activity of peptide-based drugs.展开更多
To the Editor:Due to the highly complex nature of intensity-modulated radiotherapy(IMRT)planning and delivery,patient specific quality assurance(PSQA)should be implemented to assure the reliability of treatment delive...To the Editor:Due to the highly complex nature of intensity-modulated radiotherapy(IMRT)planning and delivery,patient specific quality assurance(PSQA)should be implemented to assure the reliability of treatment delivery and improve the treatment efficacy.展开更多
基金supported by grant DP3 DK104397,R01 EY024544,P30 EY010572 from the National Institutes of Health(Bethesda,MD)by unrestricted departmental funding from Research to Prevent Blindness(New York,NY)
文摘Age-related macular degeneration(AMD)has been classified in two groups,neovascular and non-neovascular,which historically has been synonymous with exudative and non-exudative,respectively.Neovascular AMD occurs when pathologic blood vessels,choroidal
文摘The cause of glaucoma,a disease defined by degeneration of retinal ganglion cells associated with cupping of the optic nerve head(ONH)and progressive vision loss,continues to be debated despite numerous advances in ophthalmic imaging and diagnostics.Although elevated intraocular pressure is often implicated,many studies,using a variety of imaging techniques including plain fundus photography,fluorescein angiography,laser Doppler flowmetry,and color Doppler ultrasound(1-4),have suggested that insufficiencies of ONH circulation may play a role in glaucoma pathogenesis.While all of these imaging modalities have been informative,each has a set of limitations,including low spatial resolution,invasiveness,restriction to superficial vessels,lack of repeatability,and modality specific artifacts.Optical coherence tomography angiography(OCTA),an imaging technology that can produce high resolution,three-dimensional images of fundus microcirculation,is well suited to overcome many of these limitations(5).
基金supported by NIH R01AI152416(to Jianfeng Cai,USA)NIH R01 AG056569(to Jianfeng Cai,USA)。
文摘Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucagon-like peptide 1(GLP-1)is of significant clinical interest for the treatment of type-2 diabetes mellitus,but its in vivo instability and short half-life have largely prevented its therapeutic application.Here,we describe the rational design of a series of a/sulfono-γ-AA peptide hybrid analogues of GLP-1 as the GLP-1R agonists.Certain GLP-1 hybrid analogues exhibited enhanced stability(t_(1/2)>14 days)compared to t_(1/2)(<1 day)of GLP-1 in the blood plasma and in vivo.These newly developed peptide hybrids may be viable alternative of semaglutide for type-2 diabetes treatment.Additionally,our findings suggest that sulfono-γ-AA residues could be adopted to substitute canonical amino acids residues to improve the pharmacological activity of peptide-based drugs.
基金National Key Research and Development Program of China(Nos.2021YFE0202500 and 2019YFF01014403)Beijing Municipal Commission of Science and Technology Collaborative Innovation Project(No.Z221100003522028)+1 种基金the National Natural Science Foundation of China(Nos.11735003,11975041,and 11961141004)the fundamental Research Funds for the Central Universities.
文摘To the Editor:Due to the highly complex nature of intensity-modulated radiotherapy(IMRT)planning and delivery,patient specific quality assurance(PSQA)should be implemented to assure the reliability of treatment delivery and improve the treatment efficacy.
