The Treatment of Partial-Thickness Burns with a Hydroconductive Wound Dressing: Clinical and Mechanistic Effects

Objectives: Edema in partial-thickness burn wounds can decrease tissue perfusion, increase tissue ischemia, and deepen the burn injury. We report the results of a clinical trial comparing the effectiveness of a hydro-conductive dressing to our standard burn dressing at removing edema fluid from partial-thickness burns and present the proposed mechanisms of action of the hydroconductive dressing. Methods: An internally controlled comparison of two wound dressings was performed on 10 patients with non-contiguous partial-thickness burns. Each patient served as his/her own control. One burn was treated with our standard burn dressing and the other with hydroconductive dressing. Dressings were weighed prior to application, removed at 24 and 48 hours, weighed, and new pre-weighed dressings applied. Weight gain of each dressing at 24 and 48 hours was determined. Statistics were applied using the Student’s paired T-test. The VAS pain scale was measured prior to, during, and after each dressing change. Results: At 24 hours, the hydroconductive dressing had increased 85.6% ± 29.3% in weight compared with 61.3% ± 32.7% for the control (P = 0.053). For the second 24 hour period, the respective numbers were statistically significantly different at 59.7% ± 23.4% vs. 34.2% ± 19.1% (P = 0.038). Averaging the weight gain over the two dressing periods demonstrated that the differences were highly statistically significant as the hydroconductive dressing increased in weight by 71.0% ± 20.3% compared with 44.5% ± 17.4% for the gauze dressing (P = 0.005). VAS scores revealed no statistical differences. Mechanisms of action included capillary, hydroconductive, and electrostatic actions. Conclusions: A hydroconductive dressing designed to draw off excessive wound fluid removes more wound edema fluid than standard burn gauze dressings.

背阔肌皮瓣乳房再造术设计算法（摘要）

目的肿瘤外科医师对手术技术的改进，使乳腺癌切除术后残留的乳房形态得到改善。以背阔肌皮瓣行乳房再造术效果肯定。本研究将评估不同类型的用于乳房再造术的背阔肌皮瓣的皮岛设计，寻找一种广泛用于修复各种乳腺癌切除术后缺损的背阔肌皮瓣设计算法设计原则。方法本研究回顾性分析自2001年2月至2005年4月收治的单侧或双侧乳腺癌切除术后背阔肌皮瓣乳房再造患者的临床资料。在掌握如下情况的前提下进行再造手术：①术前组织是否经放疗处理；②体质量指数是否〉30；③当前有无吸烟习惯；④之前是否做过腹腔骨盆手术；⑤患者的要求。并对患者依据缺损形式进行分组：①乳房下皱襞完整但皮肤量不足；②乳房下皱襞完整且皮肤量足够；③乳房下皱襞缺损伴或不伴皮肤量不足。根据缺损的不同。设计不同的皮岛来优化手术效果，并减少供区瘢痕形成。结果本组患者54例，共应用64块背阔肌皮瓣行乳房再造术。各组间术后外观美学效果及供区瘢痕形成情况不同。结论本研究制定了一种背阔肌皮瓣乳房再造术的相关算法设计模式。通过对乳腺癌切除术后缺损的准确评价，在利用背阔肌皮瓣进行乳房再造术时，可定向切取皮岛，减少供区瘢痕形成，提高美学效果，获得疗效持久、外观自然、美观的乳房。

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

墙砍动人的液体在表面上施加的应力(WSS ) 关于脉管的功能包括那些影响许多过程。WSS 在正常生理学起一个重要作用(例如 angiogenesis ) 并且影响微脉管系统分子的运输的主要功能。波动的 WSS 的点在很多疾病显示出畸形；然而，为在生理的系统直接测量 WSS 没有确定的技术。所有当前的方法依靠大批从测量速度坡度获得的估计流动数据。在这个工作，我们报导能直接与亚微米在 microfluidic 房间测量 WSS 的 nanosensor 由使用病毒的一种特定的类型的空间分辨率，抗菌素 M13，它荧光灯地被标记并且抛锚到表面。nanosensor 能为生物织物被校准并且适应，这被表明，揭示 WSS 在不能从体积流动大小精确地计算的房间微域。这个方法在生物学和 microfluidics 把自己借给对许多应用程序适用的一个平台。