Activation of myeloid cells by human endogenous retroviral entities:While the exact causes of neurological diseases such as multiple sclerosis(MS)or amyotrophic lateral sclerosis(ALS)are still elusive,there is evidenc...Activation of myeloid cells by human endogenous retroviral entities:While the exact causes of neurological diseases such as multiple sclerosis(MS)or amyotrophic lateral sclerosis(ALS)are still elusive,there is evidence of a new category of pathogenic elements called human endogenous retroviruses(HERVs)which seem to contribute to their evolution and progression by exerting inflammatory and degenerative effects(Kury et al.,2018).HERVs are ancient retroviral elements which account for up to 8%of the human genome and it is known that environmental factors can trigger their(re-)expression(Kury et al.,2018).The resulting production of viral particles and/or proteins,especially from members of the HERV-W and HERV-K family,is strongly correlated with the onset and progression of neurological diseases,such as MS and ALS(Kury et al.,2018).展开更多
Multiple sclerosis （MS） is a chronic, inflammatory and neu- rodegenerative disease of the central nervous system （CNS） affecting at least 2.5 million people worldwide. While the relapsing subtypes of MS are well t...Multiple sclerosis （MS） is a chronic, inflammatory and neu- rodegenerative disease of the central nervous system （CNS） affecting at least 2.5 million people worldwide. While the relapsing subtypes of MS are well treatable, the disease per se remains incurable and results in progressive disability. Its etiology is complex and far from being understood.展开更多
基金supported by the French societies ARSEP(Fondation pour l’Aideàla Recherche sur la Sclérose en Plaques)and AFM(Association Fran?aise Contre les Myopathies)DMSG Ortsvereinigung Düsseldorf und Umgebung e.V.as well as by Geneuro.JG is a student of the i Brain graduate school+2 种基金PK and JG are supported by the Stifterverband/NovartisstiftungDK was funded by the Deutsche Forschungsgemeinschaft(DFG)while carrying research on HERVs at Cleveland ClinicThe MS Center at the Department of Neurology is supported in part by the Walter and Ilse Rose Foundation and the James and Elisabeth Cloppenburg,Peek,and Cloppenburg Düsseldorf Stiftung
文摘Activation of myeloid cells by human endogenous retroviral entities:While the exact causes of neurological diseases such as multiple sclerosis(MS)or amyotrophic lateral sclerosis(ALS)are still elusive,there is evidence of a new category of pathogenic elements called human endogenous retroviruses(HERVs)which seem to contribute to their evolution and progression by exerting inflammatory and degenerative effects(Kury et al.,2018).HERVs are ancient retroviral elements which account for up to 8%of the human genome and it is known that environmental factors can trigger their(re-)expression(Kury et al.,2018).The resulting production of viral particles and/or proteins,especially from members of the HERV-W and HERV-K family,is strongly correlated with the onset and progression of neurological diseases,such as MS and ALS(Kury et al.,2018).
基金supported by the Jürgen Manchot Foundation Düsseldorfby the research commission of the medical faculty of Heinrich-Heine-University of Düsseldorf+1 种基金by a grant of Sanofi Genzymesupported in part by the Walter and Ilse Rose Foundation and the James and Elisabeth Cloppenburg,Peek&Cloppenburg Düsseldorf Stiftung
文摘Multiple sclerosis （MS） is a chronic, inflammatory and neu- rodegenerative disease of the central nervous system （CNS） affecting at least 2.5 million people worldwide. While the relapsing subtypes of MS are well treatable, the disease per se remains incurable and results in progressive disability. Its etiology is complex and far from being understood.
