Rejection is one of the key factors that determine the long-term allograft function and survival in renal transplant patients. Reliable and timely diagnosis is important to treat rejection as early as possible. Allogr...Rejection is one of the key factors that determine the long-term allograft function and survival in renal transplant patients. Reliable and timely diagnosis is important to treat rejection as early as possible. Allograft biopsies are not suitable for continuous monitoring of rejection. Thus, there is an unmet need for non-invasive methods to diagnose acute and chronic rejection. Proteomics in urine and blood samples has been explored for this purpose in 29 studies conducted since 2003. This review describes the different proteomic approaches and summarizes the results from the studies that examined proteomics for the rejection diagnoses. The potential limitations and open questions in establishing proteomic markers for rejection are discussed, including ongoing trials and future challenges to this topic.展开更多
Upstream-downstream relationships of annual streamflow discharges and severity and frequency of stream-flow drought events are critical in understanding how streamflow droughts propagate over time and space. Such info...Upstream-downstream relationships of annual streamflow discharges and severity and frequency of stream-flow drought events are critical in understanding how streamflow droughts propagate over time and space. Such information can be used to resolve water disputes, trigger mitigation strategies, and understand how streamflow changes due to changes in the environment. During drought years, such information is even more critical as water resources are contested. The objective of this research is to study the upstream-downstream relationships of streamflow in Nebraska along four major river systems with diverse hydrologic characteris-tics and human activities: North Platte, Big Blue, Republican, and Niobrara. The relationships among the upstream and downstream stations along the four rivers are investigated by comparing several statistics de-rived from the annual flow discharge and on drought events. Trend analysis and coefficient of variation are applied to annual flow discharge values, and a host of drought-related parameters (e.g., annual maximum drought duration, annual accumulated drought duration, number of drought events) are also computed with respect to five different levels of streamflow drought events: water shortage, mild drought, moderate drought, significant drought, and extreme drought. The paired-t test and ANOVA with MIXED procedure are subse-quently applied to the statistics to observe whether there is a significant difference between upstream and downstream stations along a river. The analysis allows us to characterize the upstream-downstream relation-ships of the four river systems, laying the groundwork for further investigations to identify the reasons for some of the trends and observations. These findings will be essential in water resources management during or prior to hydrological droughts.展开更多
基金Supported by The Deutsche Forschungsgemeinschaft,No.GW 4/6-1
文摘Rejection is one of the key factors that determine the long-term allograft function and survival in renal transplant patients. Reliable and timely diagnosis is important to treat rejection as early as possible. Allograft biopsies are not suitable for continuous monitoring of rejection. Thus, there is an unmet need for non-invasive methods to diagnose acute and chronic rejection. Proteomics in urine and blood samples has been explored for this purpose in 29 studies conducted since 2003. This review describes the different proteomic approaches and summarizes the results from the studies that examined proteomics for the rejection diagnoses. The potential limitations and open questions in establishing proteomic markers for rejection are discussed, including ongoing trials and future challenges to this topic.
文摘Upstream-downstream relationships of annual streamflow discharges and severity and frequency of stream-flow drought events are critical in understanding how streamflow droughts propagate over time and space. Such information can be used to resolve water disputes, trigger mitigation strategies, and understand how streamflow changes due to changes in the environment. During drought years, such information is even more critical as water resources are contested. The objective of this research is to study the upstream-downstream relationships of streamflow in Nebraska along four major river systems with diverse hydrologic characteris-tics and human activities: North Platte, Big Blue, Republican, and Niobrara. The relationships among the upstream and downstream stations along the four rivers are investigated by comparing several statistics de-rived from the annual flow discharge and on drought events. Trend analysis and coefficient of variation are applied to annual flow discharge values, and a host of drought-related parameters (e.g., annual maximum drought duration, annual accumulated drought duration, number of drought events) are also computed with respect to five different levels of streamflow drought events: water shortage, mild drought, moderate drought, significant drought, and extreme drought. The paired-t test and ANOVA with MIXED procedure are subse-quently applied to the statistics to observe whether there is a significant difference between upstream and downstream stations along a river. The analysis allows us to characterize the upstream-downstream relation-ships of the four river systems, laying the groundwork for further investigations to identify the reasons for some of the trends and observations. These findings will be essential in water resources management during or prior to hydrological droughts.
