Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing.In sub-Saharan Africa,for example,the landscape is becoming ever more heteroge...Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing.In sub-Saharan Africa,for example,the landscape is becoming ever more heterogeneous as there are several species of Schistosoma that respond in different ways to ongoing preventive chemotherapy and the inter-sectoral interventions currently applied.The major focus of preventive chemotherapy is delivery of praziquantel by mass drug administration to those shown to be,or presumed to be,at-risk of infection and disease.In some countries,regional progress may be uneven but in certain locations there are very real prospects to transition from control into interruption of transmission,and ultimately elimination.To manage this transition requires reconsideration of some of the currently deployed diagnostic tools used in surveillance and downward realignment of existing prevalence thresholds to trigger mass treatment.A key challenge will be maintaining and if possible,expanding the current donation of praziquantel to currently overlooked groups,then judging when appropriate to move from mass drug administration to selective treatment.In so doing,this will ensure the health system is adapted,primed and shown to be cost-effective to respond to these changing disease dynamics as we move forward to 2020 targets and beyond.展开更多
More than 100 million people are facing a return to extreme poverty because of coronavirus disease 2019(COVID-19),while new estimates suggest that three nations—India,Nigeria,and the Democratic Republic of the Congo-...More than 100 million people are facing a return to extreme poverty because of coronavirus disease 2019(COVID-19),while new estimates suggest that three nations—India,Nigeria,and the Democratic Republic of the Congo-may suffer the greatest economic contractions.Such findings will have profound consequences in terms of our ability to control or eliminate the most widely prevalent neglected tropical diseases.展开更多
With the coronavirus disease 2019(COVID-19)pandemic showing no signs of abating,resuming neglected tropical disease(NTD)activities,particularly mass drug administration(MDA)Z is vital.Failure to resume activities will...With the coronavirus disease 2019(COVID-19)pandemic showing no signs of abating,resuming neglected tropical disease(NTD)activities,particularly mass drug administration(MDA)Z is vital.Failure to resume activities will not only enhance the risk of NTD transmission,but will fail to leverage behaviour change messaging on the importance of hand and face washing and improved sanitation--a common strategy for several NTDs that also reduces the risk of COVID-19 spread.This so-called"hybrid approach"will dem on strate best practices for mitigating the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by incorporating physical distancing,use of masks,and frequent hand-washing in the delivery of medicines to endemic communities and support action against the transmission of the virus through water,sanitation and hygiene interventions promoted by NTD programmes.Unless MDA and morbidity management activities resume,achievement of NTD targets as projected in the WHO/NTD Roadmap(2021-2030)will be deferred,the aspirational goal of NTD programmes to enhance universal health coverage jeopardised and the call to leave no one behind'a hollow one.We outline what implementing this hybrid approach,which aims to strengthen health systems,and facilitate integration and cross-sector collaboration,can achieve based on work undertaken in several African countries.展开更多
基金The COUNTDOWN consortium receives funding from the Research and Evidence Division,Department for International Development,UKLATT received financial support from the Bill&Melinda Gates Foundation,Grand Challenges Explorations.
文摘Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing.In sub-Saharan Africa,for example,the landscape is becoming ever more heterogeneous as there are several species of Schistosoma that respond in different ways to ongoing preventive chemotherapy and the inter-sectoral interventions currently applied.The major focus of preventive chemotherapy is delivery of praziquantel by mass drug administration to those shown to be,or presumed to be,at-risk of infection and disease.In some countries,regional progress may be uneven but in certain locations there are very real prospects to transition from control into interruption of transmission,and ultimately elimination.To manage this transition requires reconsideration of some of the currently deployed diagnostic tools used in surveillance and downward realignment of existing prevalence thresholds to trigger mass treatment.A key challenge will be maintaining and if possible,expanding the current donation of praziquantel to currently overlooked groups,then judging when appropriate to move from mass drug administration to selective treatment.In so doing,this will ensure the health system is adapted,primed and shown to be cost-effective to respond to these changing disease dynamics as we move forward to 2020 targets and beyond.
文摘More than 100 million people are facing a return to extreme poverty because of coronavirus disease 2019(COVID-19),while new estimates suggest that three nations—India,Nigeria,and the Democratic Republic of the Congo-may suffer the greatest economic contractions.Such findings will have profound consequences in terms of our ability to control or eliminate the most widely prevalent neglected tropical diseases.
基金The Ascend West and Central Project receives a grant from the Foreign,Common wealth and Developme nt Office of the UK Gover nment Grant/Contract No.PO 8476.
文摘With the coronavirus disease 2019(COVID-19)pandemic showing no signs of abating,resuming neglected tropical disease(NTD)activities,particularly mass drug administration(MDA)Z is vital.Failure to resume activities will not only enhance the risk of NTD transmission,but will fail to leverage behaviour change messaging on the importance of hand and face washing and improved sanitation--a common strategy for several NTDs that also reduces the risk of COVID-19 spread.This so-called"hybrid approach"will dem on strate best practices for mitigating the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by incorporating physical distancing,use of masks,and frequent hand-washing in the delivery of medicines to endemic communities and support action against the transmission of the virus through water,sanitation and hygiene interventions promoted by NTD programmes.Unless MDA and morbidity management activities resume,achievement of NTD targets as projected in the WHO/NTD Roadmap(2021-2030)will be deferred,the aspirational goal of NTD programmes to enhance universal health coverage jeopardised and the call to leave no one behind'a hollow one.We outline what implementing this hybrid approach,which aims to strengthen health systems,and facilitate integration and cross-sector collaboration,can achieve based on work undertaken in several African countries.
