Introduction: Predictors of lung function decline in systemic sclerosis (SSc) are unknown. Serum pneumoprotein levels, surfactant protein-D (SP-D) and Krebs von den Lungen-6 (KL-6), correlate with pulmonary damage. We...Introduction: Predictors of lung function decline in systemic sclerosis (SSc) are unknown. Serum pneumoprotein levels, surfactant protein-D (SP-D) and Krebs von den Lungen-6 (KL-6), correlate with pulmonary damage. We aimed to test whether levels can predict rapid lung function decline in SSc. Methods: SSc patients who had serial pulmonary function tests (PFT) were analyzed for SP-D and KL-6 levels by enzyme linked immunosorbent assay. Levels were correlated with an annual rate of decline in % predicted forced vital capacity (FVC) of >﹣2% (out-come);controls did not experience this FVC decline. Uni- and multi-variate analysis, adjusting for age, disease duration, gender, baseline % predicted FVC, SP-D, and KL-6, was performed. Results are reported as mean ± SD. Results: Thirty three cases and 25 controls had a disease duration of 8.8 ± 7.3 and 8.3 ± 6.1 years, respectively. In adjusted analyses, lung function decline correlated with greater baseline FVC OR = 1.03 [95% CI of 1.00-1.07];a trend towards significance was observed for greater levels of SP-D with FVC decline, OR = 1.37 [95% CI of 0.96-2.12]. Conclusion: Our data provide evidence that SSc patients with long-standing disease are still at risk for lung function decline and SP-D levels may predict lung function decline.展开更多
We report an efficient power tapping device working in near infra-red (800 nm) wavelength region based on UV-in- scribed 45° tilted fiber grating (45°-TFG) structure. Five 45°-TFGs were UV-inscribed in ...We report an efficient power tapping device working in near infra-red (800 nm) wavelength region based on UV-in- scribed 45° tilted fiber grating (45°-TFG) structure. Five 45°-TFGs were UV-inscribed in hydrogenated PS750 fiber using a custom-designed phase mask with different grating lengths of 3 mm, 5 mm, 9 mm, 12 mm and 15 mm, showing polarization dependent losses (PDLs) of 1 dB, 3 dB, 7 dB, 10 dB and 13 dB, respectively. The power side-tapping efficiency is clearly depending on the grating strength. It has been identified that the power tapping efficiency increases with the grating strength and deceases along the grating length. The side-tapped power profile has also been examined in azimuthal direction, showing a near-Gaussian distribution. These experimental results clearly demonstrated that 45°- TFGs may be used as in-fiber power tapping devices for applications requiring in-line signal monitoring.展开更多
目的 营养液可延长移植物的存储时间。本文将探讨应用Wisconsin大学保存液（UW液）灌注组织（皮瓣），使其耐受缺血，以延长皮片保存时间和提高延期移植的成活率。方法设计小鼠模型，评估待植断层皮片及全厚皮片在普通生理盐水、UW液和R...目的 营养液可延长移植物的存储时间。本文将探讨应用Wisconsin大学保存液（UW液）灌注组织（皮瓣），使其耐受缺血，以延长皮片保存时间和提高延期移植的成活率。方法设计小鼠模型，评估待植断层皮片及全厚皮片在普通生理盐水、UW液和Roswell Park Memorial Institute（RPMI）-1640培养基中的活力。将取下的皮片在4℃下分别储存1，2，4，7，10d，然后回植并分别测定其成活百分率。结果在储存期内，保存在UW液中的断层皮片与在生理盐水和RPMI—1640中的相比，植皮效果明显改善；而3种液体保存的全厚皮片无明显差异。结论选用UW液储存断层皮片进行异体植皮或延期植皮可延长储皮时间，并可在保质期内明显改善植皮效果。本研究发现，更厚的皮片厚度会限制保存液的渗透力，从而限制储存全厚皮片的能力。展开更多
文摘Introduction: Predictors of lung function decline in systemic sclerosis (SSc) are unknown. Serum pneumoprotein levels, surfactant protein-D (SP-D) and Krebs von den Lungen-6 (KL-6), correlate with pulmonary damage. We aimed to test whether levels can predict rapid lung function decline in SSc. Methods: SSc patients who had serial pulmonary function tests (PFT) were analyzed for SP-D and KL-6 levels by enzyme linked immunosorbent assay. Levels were correlated with an annual rate of decline in % predicted forced vital capacity (FVC) of >﹣2% (out-come);controls did not experience this FVC decline. Uni- and multi-variate analysis, adjusting for age, disease duration, gender, baseline % predicted FVC, SP-D, and KL-6, was performed. Results are reported as mean ± SD. Results: Thirty three cases and 25 controls had a disease duration of 8.8 ± 7.3 and 8.3 ± 6.1 years, respectively. In adjusted analyses, lung function decline correlated with greater baseline FVC OR = 1.03 [95% CI of 1.00-1.07];a trend towards significance was observed for greater levels of SP-D with FVC decline, OR = 1.37 [95% CI of 0.96-2.12]. Conclusion: Our data provide evidence that SSc patients with long-standing disease are still at risk for lung function decline and SP-D levels may predict lung function decline.
文摘We report an efficient power tapping device working in near infra-red (800 nm) wavelength region based on UV-in- scribed 45° tilted fiber grating (45°-TFG) structure. Five 45°-TFGs were UV-inscribed in hydrogenated PS750 fiber using a custom-designed phase mask with different grating lengths of 3 mm, 5 mm, 9 mm, 12 mm and 15 mm, showing polarization dependent losses (PDLs) of 1 dB, 3 dB, 7 dB, 10 dB and 13 dB, respectively. The power side-tapping efficiency is clearly depending on the grating strength. It has been identified that the power tapping efficiency increases with the grating strength and deceases along the grating length. The side-tapped power profile has also been examined in azimuthal direction, showing a near-Gaussian distribution. These experimental results clearly demonstrated that 45°- TFGs may be used as in-fiber power tapping devices for applications requiring in-line signal monitoring.
文摘目的 营养液可延长移植物的存储时间。本文将探讨应用Wisconsin大学保存液（UW液）灌注组织（皮瓣），使其耐受缺血，以延长皮片保存时间和提高延期移植的成活率。方法设计小鼠模型，评估待植断层皮片及全厚皮片在普通生理盐水、UW液和Roswell Park Memorial Institute（RPMI）-1640培养基中的活力。将取下的皮片在4℃下分别储存1，2，4，7，10d，然后回植并分别测定其成活百分率。结果在储存期内，保存在UW液中的断层皮片与在生理盐水和RPMI—1640中的相比，植皮效果明显改善；而3种液体保存的全厚皮片无明显差异。结论选用UW液储存断层皮片进行异体植皮或延期植皮可延长储皮时间，并可在保质期内明显改善植皮效果。本研究发现，更厚的皮片厚度会限制保存液的渗透力，从而限制储存全厚皮片的能力。
