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The Effect of Torsion Deformity and Medial Knee Osteoarthritis on Lower Limb Extensor Moments during Gait 被引量:1
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作者 david s. mandeville Kenneth A. Krackow +1 位作者 sridhar R. Rachala Mary Bayers-Thering 《Open Journal of Rheumatology and Autoimmune Diseases》 2013年第2期119-124,共6页
The aim of this study was to quantify the effect of torsion deformity on the lower limb kinetics during the loading response phase of gait. A total of 24 subjects: 6 end-staged medial knee OA with torsion deformity (T... The aim of this study was to quantify the effect of torsion deformity on the lower limb kinetics during the loading response phase of gait. A total of 24 subjects: 6 end-staged medial knee OA with torsion deformity (TKO), 8 without torsion deformity (KOA), and 10 controls (CON) were imaged using computed tomography (CT). Internal moment of support and sagittal hip, knee and ankle joint moments were assessed using gait analysis. TKO showed greater external rotations of the proximal tibia and the distal femur compared to subjects with medial knee OA without torsion deformity and controls. TKO showed greater moment of support and a greater knee extensor moment when compared to controls when supporting the weight of the body during gait. The TKO intorsion deformity occurred as a result of a proximal malrotation of the tibia. In the presence of torsion deformity, the kinetic synergy of the lower limb showed increased total moment of support for subjects with medial knee OA. The greater extensor output from TKO may be the result of an increased muscular response to overcome an interrupted inter-segmental exchange of accelerations during the loading response phase of gait. 展开更多
关键词 Knee Osteoarthritis TIBIAL TORSION Computed Tomography GAIT Analysis Total Moment of Support
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Associations between Hormonal and Mechanical Factors of Knee Osteoarthritis in Women—A Preliminary Study
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作者 david s. mandeville Gretchen A. Casazza +3 位作者 Andrea C. Alvarez Julia sheremet Brandee L. Waite Brian A. Davis 《Open Journal of Rheumatology and Autoimmune Diseases》 2013年第2期79-85,共7页
The purpose of this study was to determine the associations between urinary estradiol (E2) metabolite concentration and medial knee loading with radiographic disease severity in middle aged women with initial stage kn... The purpose of this study was to determine the associations between urinary estradiol (E2) metabolite concentration and medial knee loading with radiographic disease severity in middle aged women with initial stage knee osteoarthritis (OA). Women presenting with knee pain were recruited into a cross-sectional correlation study (KOA, n = 9, age = 52 ± 4 yrs). Self report menstrual history, the Modified Baecke Questionnaire and the Knee Injury and Osteoarthritis Outcome Score (KOOS) subjective data were collected. A fasting blood sample (follicle stimulating hormone (FSH) and Tumor Necrosis Factor-α (TNF-α)), and urine catch (16α-hydroxyestrone and 2-hydroxyestrone) were collected. Gait analysis using an 8-camera motion analysis system assessed internal knee varus moment and foot progression angle. Pearson Product moments tested for associations between urinary 16α-hydroxyestrone and 2-hydroxyestrone, TNF-α, medial knee loading, and radiographic disease severity (Kellgren/Lawrence (K/L) radiographic score). Significant correlations were found within the hormonal biomarkers (r = 0.94, p p p = 0.31). No correlations were found for radiographic disease severity or TNF-α. The lack of association between hormonal and biomechanical variables could be due to large variability of the E2 metabolites seen in the menopause transition and the limited structural changes of initial staged knee OA. 展开更多
关键词 KNEE OSTEOARTHRITIS 2-Hydroxyestrone Follicle Stimulating HORMONE Gait Analysis MEDIAL KNEE Loading Tumor NECROSIS Factor-α
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