In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is incomplete.In a recent article publ...In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is incomplete.In a recent article published in Cell,Mossmann et al.find a novel signalling role for accumulated arginine in hepato-cellular carcinoma(HCC)mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).展开更多
基金support from the National Institute of General Medical Sciences,R35GM147118 to LS and PHS NRSA T32GM007270 to DS.
文摘In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is incomplete.In a recent article published in Cell,Mossmann et al.find a novel signalling role for accumulated arginine in hepato-cellular carcinoma(HCC)mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).
