Goals: To determine the long-term efficacy of endoluminal gastroplication (ELGP) and the most effective plication configuration. Background: Endoluminal gast roplication is an intriguing therapy for gastroesophageal r...Goals: To determine the long-term efficacy of endoluminal gastroplication (ELGP) and the most effective plication configuration. Background: Endoluminal gast roplication is an intriguing therapy for gastroesophageal reflux disease. We con ducted a retrospective review of a prospective experience of patient cohorts com paring outcomes of the circumferential and helical plication patterns. Study: Tw enty patients underwent ELGP, with 9 receiving the circumferential (Group 1) and 11 the helical pattern (Group 2). Manometry, endoscopy, and 24-hour pH monitor ing were performed at baseline and at 6 months. Symptom scores and medication us age were assessed at baseline, 1, 3, 6, 12, and 18months. Results: Both groups d id not differ significantly from each other with respect to symptom improvement, medication usage, or other variables measured. At 6 months, symptom scores, his tamine-2 receptor antagonist (H2RA), proton pump inhibitor usage,and hernia siz e decreased significantly. No other parameter showed a significant change. At th e 18-month follow-up, symptom scores and H2RA usage decreased significantly. C onclusion: ELGP improves heartburn and regurgitation scores at 18 months. Our st udy suggests that there is no benefit to additional placations when using the he lical pattern.展开更多
文摘Goals: To determine the long-term efficacy of endoluminal gastroplication (ELGP) and the most effective plication configuration. Background: Endoluminal gast roplication is an intriguing therapy for gastroesophageal reflux disease. We con ducted a retrospective review of a prospective experience of patient cohorts com paring outcomes of the circumferential and helical plication patterns. Study: Tw enty patients underwent ELGP, with 9 receiving the circumferential (Group 1) and 11 the helical pattern (Group 2). Manometry, endoscopy, and 24-hour pH monitor ing were performed at baseline and at 6 months. Symptom scores and medication us age were assessed at baseline, 1, 3, 6, 12, and 18months. Results: Both groups d id not differ significantly from each other with respect to symptom improvement, medication usage, or other variables measured. At 6 months, symptom scores, his tamine-2 receptor antagonist (H2RA), proton pump inhibitor usage,and hernia siz e decreased significantly. No other parameter showed a significant change. At th e 18-month follow-up, symptom scores and H2RA usage decreased significantly. C onclusion: ELGP improves heartburn and regurgitation scores at 18 months. Our st udy suggests that there is no benefit to additional placations when using the he lical pattern.
