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阿魏酸纳米醇质体的制备、表征及体外经皮吸收研究
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作者 邓梦洁 易国斌 +3 位作者 吕冉 柳亚锋 叶大威 陈佳志 《日用化学工业(中英文)》 CAS 北大核心 2023年第11期1285-1292,共8页
研究了微射流技术制备的阿魏酸纳米醇质体经皮递送和抗氧化性能。首先,采用响应面法研究了卵磷脂、边缘活化剂(蔗糖棕榈酸酯、吐温-80)对阿魏酸纳米醇质体包封率的影响,优化得到:卵磷脂、蔗糖棕榈酸酯与吐温-80为0.68%∶0.51%∶0.25%(w... 研究了微射流技术制备的阿魏酸纳米醇质体经皮递送和抗氧化性能。首先,采用响应面法研究了卵磷脂、边缘活化剂(蔗糖棕榈酸酯、吐温-80)对阿魏酸纳米醇质体包封率的影响,优化得到:卵磷脂、蔗糖棕榈酸酯与吐温-80为0.68%∶0.51%∶0.25%(w/%)时,所制备的阿魏酸纳米醇质体粒径小且分布均匀((104.5±0.7)nm),PDI为0.05±0.01,包封率高(88.8%±2.6%),稳定性高(25℃稳定存放60天)。其次,采用DPPH自由基清除实验和Franz扩散池体外透皮实验分别评价了阿魏酸纳米醇质体的抗氧化性能和经皮递送性能,阿魏酸纳米醇质体的IC_(50)值为8.7μg/mL,抗氧化活性略高于阿魏酸丙二醇水溶液(IC_(50)值为11.7μg/mL);阿魏酸纳米醇质体皮肤滞留量和累积透过量分别为(18.2±3.5)μg/cm^(2)和(25.3±3.2)μg/cm^(2),分别是阿魏酸丙二醇水溶液的1.2倍和1.4倍。研究发现,制备的阿魏酸纳米醇质体粒径均一、包封率高、稳定性好且抗氧化性高、经皮吸收性能好,有望用于酚酸类天然活性物经皮递送系统,及其抗氧化、抗衰老、美白等功效化妆品。 展开更多
关键词 阿魏酸 纳米醇质体 微射流 抗氧化 经皮吸收
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Experimental investigation on divertor tungsten sputtering with neon seeding in ELMy H-mode plasma in EAST tokamak
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作者 dawei ye Fang Ding +15 位作者 Kedong Li Zhenhua Hu Ling Zhang Xiahua Chen Qing Zhang Pingan Zhao Tao He Lingyi Meng Kaixuan ye Fubin Zhong Yanmin Duan Rui Ding Liang Wang Guosheng Xu Guangnan Luo EAST team 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第6期512-517,共6页
Neon(Ne)seeding is used to cool the edge plasma by radiation to protect the divertor tungsten(W)target in the Experimental Advanced Superconducting Tokamak(EAST).The W sputtering in the outer divertor target with Ne s... Neon(Ne)seeding is used to cool the edge plasma by radiation to protect the divertor tungsten(W)target in the Experimental Advanced Superconducting Tokamak(EAST).The W sputtering in the outer divertor target with Ne seeding is assessed by the divertor visible spectroscopy system.It is observed that the W sputtering flux initially increases with Ne concentration in the divertor despite the decreasing plasma temperature.After reaching a maximum around 25 eV,the W sputtering rate starts to decrease,presenting a suppression effect.The effect on the divertor W sputtering flux and yield due to the competition between the increase of the Ne concentration and the decrease of the plasma temperature is discussed.The results show that enough Ne seeding is essential to effectively reduce the electron temperature and thus to suppress W sputtering.Moreover,ELM suppression is observed when Ne and W impurities enter the core plasma,which could be correlated to the enhanced turbulence transport in the pedestal. 展开更多
关键词 neon seeding tungsten sputtering ELM suppression EAST tokamak
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