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外观健康的癌症生存者的运动能力
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作者 de caro e. Fioredda F. +2 位作者 Calevo M.G. G. Pongiglione 张振 《世界核心医学期刊文摘(儿科学分册)》 2006年第5期9-9,共1页
Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appa rently healthy paediatric cancer survivors in order to determine their participa tion in sporting activities. Methods: A total of 84 young... Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appa rently healthy paediatric cancer survivors in order to determine their participa tion in sporting activities. Methods: A total of 84 young (< 21 years) asy- mptomatic childhood cancer survivors, who had been exposed to anthracyclines ( mean dose 212 mg/m2) and/or chest irradiation (median dose 2000 cGy), with norma l left ventricular systolic function at rest (fractional shortening > 29%), and 79 healthy controls were studied. Exercise testing was performed on a treadmill ergometer. Gas exchange analysis and derived variables were measured on a breat h-by-breath basis. Pulmonary functional evaluation was performed before exerci se. Echocardiographic evaluation at rest was performed within one month before t he exercise test. Results: There were no differences in exercise responses betwe en patients and controls. In boys < 13 years, mean VO2 max was slightly but sign ificantly lower than in controls. This finding was thought to be a result of dec reased physical fitness as all the other exercise parameters were similar to those in the controls. Conclusions: Results show that apparently healthy survivors of paediatric cancer can take part in dynamic sporting activities if they exhibi t a normal response to cardiopulmonary exercise testing, while those that exhibi t a reduced VO2 max should be re-evaluated after an aerobic training programme, and should undergo tailored dynamic physical activity if the VO2 max does not n ormalise. 展开更多
关键词 癌症生存者 运动能力 健康 外观 左室收缩功能正常 左室短轴缩短率 平均剂量 蒽环类药物 体育活动 运动耐量
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