A new ionone glycoside （6R,9R）-blumenyl α-L-rhamnopyranosyl-（1 → 6）-β-D-gluco-pyranoside （1）, together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-（1 → 6）-β-D-glucopy...A new ionone glycoside （6R,9R）-blumenyl α-L-rhamnopyranosyl-（1 → 6）-β-D-gluco-pyranoside （1）, together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-（1 → 6）-β-D-glucopyranoside （2）, was isolated from the leaves ofNeoalsomitra integrifoliola. Their structures were elucidated by chemical and spectral analysis. Compound 1 showed weak anti-inflammatory and low-level antioxidant activities.展开更多
Triptophenolide methyl ether and iso-triptophenolidemethl ether were synthesized from triptophenolide .It is comfirmed that the triptophenolide structure which DFYu reported in 1990 is not corect by analysis of 1HNMR...Triptophenolide methyl ether and iso-triptophenolidemethl ether were synthesized from triptophenolide .It is comfirmed that the triptophenolide structure which DFYu reported in 1990 is not corect by analysis of 1HNMR and (13)CNMR data of these two compounds.展开更多
A new isoprenylated flavonol, named broussonol A (1) was isolated from the leaves of Broussonetia kazinoki Sieb. The structure of broussonol A was characterized by chemical and spectral methods.
A new dihydroflavone (1), named macrophyllol A, was isolated from the roots of Uvaria macrophylla. Its structure was elucidated on the basis of spectroscopic evidence.
A new sesquiterpenoid compound named ligustilone was isolated from the roots of Ligusticum sinense Oliv. Based on the chemical and spectral studies especially 2DNMR including H-1, H-1 COSY, H-1, C-13 COSY and COLOC te...A new sesquiterpenoid compound named ligustilone was isolated from the roots of Ligusticum sinense Oliv. Based on the chemical and spectral studies especially 2DNMR including H-1, H-1 COSY, H-1, C-13 COSY and COLOC techniques, its structure has been established as a bisabolane derivative and showed as 1. The absolute configuration was determined by CD data.展开更多
A new diterpene lactone with an ent--kaurane skeleton, named antriptolactone(1) was isolated from the roots of Tripterygium wilfordii cellected in Anhui province. Its structure was elucidated by spectral data and chem...A new diterpene lactone with an ent--kaurane skeleton, named antriptolactone(1) was isolated from the roots of Tripterygium wilfordii cellected in Anhui province. Its structure was elucidated by spectral data and chemical transformtion.展开更多
Ligustiphenol (1), a new sesquiterpenoid with bisabolane skeleton, has beenisolated from the alcohol extract of roots of Ligusticum silence Oliv, and its strcutureincluding absolute configuration established on the ba...Ligustiphenol (1), a new sesquiterpenoid with bisabolane skeleton, has beenisolated from the alcohol extract of roots of Ligusticum silence Oliv, and its strcutureincluding absolute configuration established on the basis of spectral and chemicalevidences.展开更多
One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting...One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting materials.展开更多
By means of variable temperature NMR spectra, conformation of 8-C-glucosyl prunetin, isolated from the leaves of Dalbergia hainanensis (Leguminosae), was studied. The restricted rotation around the C (sp3)-C (sp2) bo...By means of variable temperature NMR spectra, conformation of 8-C-glucosyl prunetin, isolated from the leaves of Dalbergia hainanensis (Leguminosae), was studied. The restricted rotation around the C (sp3)-C (sp2) bond in the C-glucosides isoflavonoid results in two main conformers (syn and anti). With the help of MM calculation, the preferred conformation A has H-1 gauche to the 7-OCH3. The barrier to rotation was 18.1 kcal/mol. This result agrees with the calculated value 16.2 kcal/mol of free energy of activation for the interconversion between the conformers.展开更多
Two new compounds, gonioquinone (1) and goniofufurone acetonide (2), have been isolated from the roots of Goniothalamus cheliensis Hu. Their structures were determined on the basis of spectral and chemical evidence.
Two new styryllactones, iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone, were isolated from the roots of Goniothalamus cheliensis. Their structure were elucidated on the basis of spectroscopic and chemical eviden...Two new styryllactones, iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone, were isolated from the roots of Goniothalamus cheliensis. Their structure were elucidated on the basis of spectroscopic and chemical evidences.展开更多
A new flavanone named macrouroine C (1) was isolated from the bark of Morus macroura Miq.. The structure of 1 was elucidated mainly on the basis of spectroscopic evidence.
Three new compounds, suspenolic acid (1), forsythenside A (2), and forsythenside B (3) have been isolated from the fruits of Forsythia suspensa. Their structures were elucidated by spectral methods including IR, H-1- ...Three new compounds, suspenolic acid (1), forsythenside A (2), and forsythenside B (3) have been isolated from the fruits of Forsythia suspensa. Their structures were elucidated by spectral methods including IR, H-1- and C-13-NMR, DEPT, H-1-H-1 COSY, H-1-C-13 COSY, NOE difference, HMBC, FABMS, CIMS, and chemical reactions.展开更多
An unexpected reduction of dimethyl pyridine-2,3-dicarboxylate to 1,2,3,4-tetrahydrofuro[3,4-b]pyridin-5（7H）-one with sodium borohydride in ethanol and tetrahydrofuran, respectively, is described, a hypothetic mecha...An unexpected reduction of dimethyl pyridine-2,3-dicarboxylate to 1,2,3,4-tetrahydrofuro[3,4-b]pyridin-5（7H）-one with sodium borohydride in ethanol and tetrahydrofuran, respectively, is described, a hypothetic mechanism for the unusual reductive product is proposed.展开更多
A novel peptide designated secapin-1, was purified and characterized from Apis mellifera. The molecular weight of 25 amino acid peptide secapin-1 was found to be 2821.5625 Da by ESI-FTICR-MS. It showed high identity t...A novel peptide designated secapin-1, was purified and characterized from Apis mellifera. The molecular weight of 25 amino acid peptide secapin-1 was found to be 2821.5625 Da by ESI-FTICR-MS. It showed high identity to secapin. The sequence of secapin-1 was determined to be YIINVPPRCPPGSKFVKNKCRVIVP by automatic Edman degradation. A disulfide bond was formed between Cys9 and Cys20 residues. In addition, an analogue of secapin-1 was synthesized by solid phase peptide synthesis method. The synthesis product was successfully purified and identified to homogeneity by using a combination of SEC, IEC, and RP-HPLC techniques.展开更多
基金the National science fund for Distinguished Young Scholars (No.30625040)the Key Project of Natural Science Foundation of China (No.20432030)+1 种基金"973"Project (No.2004CB518906)PCSIRT (No.IRT0514).
文摘A new ionone glycoside （6R,9R）-blumenyl α-L-rhamnopyranosyl-（1 → 6）-β-D-gluco-pyranoside （1）, together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-（1 → 6）-β-D-glucopyranoside （2）, was isolated from the leaves ofNeoalsomitra integrifoliola. Their structures were elucidated by chemical and spectral analysis. Compound 1 showed weak anti-inflammatory and low-level antioxidant activities.
文摘Triptophenolide methyl ether and iso-triptophenolidemethl ether were synthesized from triptophenolide .It is comfirmed that the triptophenolide structure which DFYu reported in 1990 is not corect by analysis of 1HNMR and (13)CNMR data of these two compounds.
文摘A new isoprenylated flavonol, named broussonol A (1) was isolated from the leaves of Broussonetia kazinoki Sieb. The structure of broussonol A was characterized by chemical and spectral methods.
文摘A new dihydroflavone (1), named macrophyllol A, was isolated from the roots of Uvaria macrophylla. Its structure was elucidated on the basis of spectroscopic evidence.
文摘A new sesquiterpenoid compound named ligustilone was isolated from the roots of Ligusticum sinense Oliv. Based on the chemical and spectral studies especially 2DNMR including H-1, H-1 COSY, H-1, C-13 COSY and COLOC techniques, its structure has been established as a bisabolane derivative and showed as 1. The absolute configuration was determined by CD data.
文摘A new diterpene lactone with an ent--kaurane skeleton, named antriptolactone(1) was isolated from the roots of Tripterygium wilfordii cellected in Anhui province. Its structure was elucidated by spectral data and chemical transformtion.
文摘Ligustiphenol (1), a new sesquiterpenoid with bisabolane skeleton, has beenisolated from the alcohol extract of roots of Ligusticum silence Oliv, and its strcutureincluding absolute configuration established on the basis of spectral and chemicalevidences.
基金the National Natural Science Foundation of China （No 20372085） .
文摘One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting materials.
文摘By means of variable temperature NMR spectra, conformation of 8-C-glucosyl prunetin, isolated from the leaves of Dalbergia hainanensis (Leguminosae), was studied. The restricted rotation around the C (sp3)-C (sp2) bond in the C-glucosides isoflavonoid results in two main conformers (syn and anti). With the help of MM calculation, the preferred conformation A has H-1 gauche to the 7-OCH3. The barrier to rotation was 18.1 kcal/mol. This result agrees with the calculated value 16.2 kcal/mol of free energy of activation for the interconversion between the conformers.
基金This research was supported by National 973 Project(G1998051120).
文摘Two new compounds, gonioquinone (1) and goniofufurone acetonide (2), have been isolated from the roots of Goniothalamus cheliensis Hu. Their structures were determined on the basis of spectral and chemical evidence.
文摘Two new styryllactones, iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone, were isolated from the roots of Goniothalamus cheliensis. Their structure were elucidated on the basis of spectroscopic and chemical evidences.
文摘A new flavanone named macrouroine C (1) was isolated from the bark of Morus macroura Miq.. The structure of 1 was elucidated mainly on the basis of spectroscopic evidence.
文摘Three new compounds, suspenolic acid (1), forsythenside A (2), and forsythenside B (3) have been isolated from the fruits of Forsythia suspensa. Their structures were elucidated by spectral methods including IR, H-1- and C-13-NMR, DEPT, H-1-H-1 COSY, H-1-C-13 COSY, NOE difference, HMBC, FABMS, CIMS, and chemical reactions.
文摘An unexpected reduction of dimethyl pyridine-2,3-dicarboxylate to 1,2,3,4-tetrahydrofuro[3,4-b]pyridin-5（7H）-one with sodium borohydride in ethanol and tetrahydrofuran, respectively, is described, a hypothetic mechanism for the unusual reductive product is proposed.
文摘A novel peptide designated secapin-1, was purified and characterized from Apis mellifera. The molecular weight of 25 amino acid peptide secapin-1 was found to be 2821.5625 Da by ESI-FTICR-MS. It showed high identity to secapin. The sequence of secapin-1 was determined to be YIINVPPRCPPGSKFVKNKCRVIVP by automatic Edman degradation. A disulfide bond was formed between Cys9 and Cys20 residues. In addition, an analogue of secapin-1 was synthesized by solid phase peptide synthesis method. The synthesis product was successfully purified and identified to homogeneity by using a combination of SEC, IEC, and RP-HPLC techniques.
