The first synthesis of pillar[7]arene is reported with two methods.Method A：the FeCl_3-catalyzed condensation reaction of 1,4- dimethoxybenzene（1） with paraformaldehyde in CHCl_3 gave dimethoxypillar[7]arene（3）.M...The first synthesis of pillar[7]arene is reported with two methods.Method A：the FeCl_3-catalyzed condensation reaction of 1,4- dimethoxybenzene（1） with paraformaldehyde in CHCl_3 gave dimethoxypillar[7]arene（3）.Method B：the p-toluenesulfonic acid catalyzed condensation reaction of 2,5-bis（benzyloxymethyl）-1,4-dimethoxybenzene（2） in CH_2Cl_2 gave compound 3.Demethylation of 3 with BBr_3 gave pillar[7]arene（4）.The pillar[7]arene might be a perspective macrocyclic host in host-guest chemistry.展开更多
基金supported by the National Natural Science Foundation of China(Nos20872038 and 21072064)
文摘The first synthesis of pillar[7]arene is reported with two methods.Method A：the FeCl_3-catalyzed condensation reaction of 1,4- dimethoxybenzene（1） with paraformaldehyde in CHCl_3 gave dimethoxypillar[7]arene（3）.Method B：the p-toluenesulfonic acid catalyzed condensation reaction of 2,5-bis（benzyloxymethyl）-1,4-dimethoxybenzene（2） in CH_2Cl_2 gave compound 3.Demethylation of 3 with BBr_3 gave pillar[7]arene（4）.The pillar[7]arene might be a perspective macrocyclic host in host-guest chemistry.
