Background. Luteinized thecoma of the ovary associated with sclerosing peritonitis is a rare pathologic condition without a standard strategy of treatment. Case. We present the case of an ovarian luteinizing sclerosin...Background. Luteinized thecoma of the ovary associated with sclerosing peritonitis is a rare pathologic condition without a standard strategy of treatment. Case. We present the case of an ovarian luteinizing sclerosing thecoma in a 39- year- old woman. The patient underwent three laparotomic operations for subocclusive symptoms, revealing in both occasions the presence of sclerosing peritonitis, with large abdominal masses, including cysts containing clear fluid. Treatment with toremifene 20 mg/day and leuprolide resulted in a dramatic improvement of the performance status and complete remission of all the abdominal lesions. After 60 months follow- up, the patient is still disease- free. Discussion. Antiestrogens plus LHRH agonists might be a noninvasive, effective and well- tolerated therapy for sclerosing peritonitis in patient operated for luteinized thecomas.展开更多
Purpose: To determine the efficacy of echography with new generation contrast agents in visualizing vascularization of choroidal malignant melanomas. Methods: An echographic contrast medium consisting of phospholipidi...Purpose: To determine the efficacy of echography with new generation contrast agents in visualizing vascularization of choroidal malignant melanomas. Methods: An echographic contrast medium consisting of phospholipidic microbubbles filled with sulphur hexafluoride (Sonovue(r)) was used to visualize microcirculation i n 25 cases of choroidal lesions already diagnosed with standardized echography ( 21 choro- idal malignant melanomas, four disciform lesions). Results: In untreated malig nant melanomas contrast agent echography revealed the presence of a dense microc irculation inside the mass. In one case vitreal seeding of the contrast agent wa s detectable before enucleation and histological examination revealed the presen ce of tumoral cells. In 12 cases treated with transpupillary thermotherapy, cont rast agent echographic evaluation showed heavy regression of microcirculation af ter l week, confirmed in one case by histology, and a reduction of 70-80%in di mensions after 6 months (which appeared to have stabilized at subsequent examina tions). In four cases treated with proton beam brachytherapy 2 years prior to ou r examination, contrast agent echography showed the absence of a microvascular n etwork and the presence of large vessels and blood lakes. In four cases of disci form lesion, deep and superficial retina-associated vascularization was observe d, with a weak spread of contrast agent inside the lesion. Conclusion: Live repr esentation with good resolution of choroidal malignant melanoma microcirculation was obtained.展开更多
文摘Background. Luteinized thecoma of the ovary associated with sclerosing peritonitis is a rare pathologic condition without a standard strategy of treatment. Case. We present the case of an ovarian luteinizing sclerosing thecoma in a 39- year- old woman. The patient underwent three laparotomic operations for subocclusive symptoms, revealing in both occasions the presence of sclerosing peritonitis, with large abdominal masses, including cysts containing clear fluid. Treatment with toremifene 20 mg/day and leuprolide resulted in a dramatic improvement of the performance status and complete remission of all the abdominal lesions. After 60 months follow- up, the patient is still disease- free. Discussion. Antiestrogens plus LHRH agonists might be a noninvasive, effective and well- tolerated therapy for sclerosing peritonitis in patient operated for luteinized thecomas.
文摘Purpose: To determine the efficacy of echography with new generation contrast agents in visualizing vascularization of choroidal malignant melanomas. Methods: An echographic contrast medium consisting of phospholipidic microbubbles filled with sulphur hexafluoride (Sonovue(r)) was used to visualize microcirculation i n 25 cases of choroidal lesions already diagnosed with standardized echography ( 21 choro- idal malignant melanomas, four disciform lesions). Results: In untreated malig nant melanomas contrast agent echography revealed the presence of a dense microc irculation inside the mass. In one case vitreal seeding of the contrast agent wa s detectable before enucleation and histological examination revealed the presen ce of tumoral cells. In 12 cases treated with transpupillary thermotherapy, cont rast agent echographic evaluation showed heavy regression of microcirculation af ter l week, confirmed in one case by histology, and a reduction of 70-80%in di mensions after 6 months (which appeared to have stabilized at subsequent examina tions). In four cases treated with proton beam brachytherapy 2 years prior to ou r examination, contrast agent echography showed the absence of a microvascular n etwork and the presence of large vessels and blood lakes. In four cases of disci form lesion, deep and superficial retina-associated vascularization was observe d, with a weak spread of contrast agent inside the lesion. Conclusion: Live repr esentation with good resolution of choroidal malignant melanoma microcirculation was obtained.
