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经导管复制兔急性肠系膜动脉血栓栓塞模型的可行性研究 被引量:2
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作者 李娟 刘德斌 +4 位作者 何尤夫 许官学 刘西平 刘汉林 沈长银 《中国现代医学杂志》 CAS 2018年第5期18-22,共5页
目的探讨经导管复制兔急性肠系膜动脉栓塞模型的方法及可行性分析。方法新西兰大白兔20只,随机分为模型组和对照组,两组经股动脉置入6 F动脉鞘,模型组将自制的兔自体动脉血栓经指引导管注入肠系膜上动脉进行栓塞,血管造影证实栓塞成功后... 目的探讨经导管复制兔急性肠系膜动脉栓塞模型的方法及可行性分析。方法新西兰大白兔20只,随机分为模型组和对照组,两组经股动脉置入6 F动脉鞘,模型组将自制的兔自体动脉血栓经指引导管注入肠系膜上动脉进行栓塞,血管造影证实栓塞成功后2 h开腹观察腹腔肠管情况,行伊文思蓝染色,染色后处死动物切取标本行病理学检查。对照组只进行股动脉置管并行相应伊文思蓝染色及病理学检查。结果 (1)栓塞后2 h剖腹探查结果表明,与对照组对比,模型组栓塞肠管色泽变暗红,肠蠕动减弱或消失;对照组肠管颜色鲜红,肠蠕动正常。伊文思蓝染色观察表明,模型组栓塞肠管未着色。病理结果提示,模型组栓塞动脉供应区域肠管肠黏膜充血、局部区域出血,伴炎症细胞浸润,多数区域发生肠黏膜梗死;对照组肠管全蓝染色,无肠黏膜梗死。(2)D-2聚体、肌酸磷酸激酶(CK)水平在术前、术后1和2 h比较,差异有统计学意义(P<0.05),术后1 h的D-2聚体水平高于术前,而术后2 h低于术后1 h(P<0.05)。术后1和2 h的CK水平低于术前(P<0.05),而术后1 h与2 h比较,差异无统计学意义(P>0.05)。结论经导管可成功复制兔急性肠系膜动脉栓塞模型,该实验方法可控性好,成功率较高,能为急性肠系膜动脉栓塞基础研究及治疗提供可靠的动物模型。 展开更多
关键词 兔动脉阻塞 血栓 模型
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Minimally Invasive Perventricular Device Closure of Ventricular Septal Defect: a Comparative Study in 80 Patients 被引量:7
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作者 Xin-chao Yang de-bin liu 《Chinese Medical Sciences Journal》 CAS CSCD 2014年第2期98-102,共5页
Objective To evaluate the efficacy of minimally invasive perventricular device closure of ventricular septal defect(VSD). Methods Between September 2011 and February 2013, we collected 40 patients who underwent perven... Objective To evaluate the efficacy of minimally invasive perventricular device closure of ventricular septal defect(VSD). Methods Between September 2011 and February 2013, we collected 40 patients who underwent perventricular closure via a small lower sternal incision(minimally invasive group), aged 15.5±3.5 years(12 months to 32 years) with a body weight of 24.2±7.5 kg(10.8-58.0 kg). The mean size of VSD was 5.6±0.5 mm(2-14 mm). Another 40 patients were included as the surgical group, receiving the conventional surgical repair of VSD. The device of the minimally invasive group was released under the guidance of transesophageal echocardiography. Success rate, cardiac indicators, and clinical outcomes of the 2 groups were compared. Results The patients in the surgical group and those in the minimally invasive group showed similar results in success rate(both 97.5%). The procedure time, intensive care unit stay, hospital stay, and postoperative recovery time in the minimally invasive group were significantly shorter than those in the surgical group(58±21 minutes versus 145±26 minutes, 2±1 days versus 8±3 days, 5±1 days versus 16±6 days, 3±1 days versus 90±20 days, all P<0.05). The minimally invasive group had a higher incidence of conduction anomalies(17.5% versus 2.5%, P<0.05). In the follow-up period of 3-12 months, there was no new residual shunt, noticeable aortic regurgitation, significant arrhythmias, or device failure except for new complications in the surgical group. Conclusions The success rate of minimally invasive perventricular device closure of VSD under transesophageal echocardiography guidance is similar to that of conventional surgical repair, but the short-term outcomes of the minimally invasive approach is much better. Long-term follow-up is necessary to confirm the effectiveness of this technique. 展开更多
关键词 transesophageal echocardiography minimally invasive ventricular septal defect
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Transesophageal echocardiography-guided device occlusion of ventricular septal defects:a propensity score matching analysis of left anterior mini-thoracotomy vs.lower partial median sternotomy
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作者 Xiao-Feng Lu Shi-Lin Wei +3 位作者 Na-Na Li Peng-Bin Zhang Bing-Ren Gao de-bin liu 《Chinese Medical Journal》 SCIE CAS CSCD 2021年第22期2747-2749,共3页
To the Editor:Ventricular septal defect(VSD),as the most common congenital heart defect,accounts for up to 40%of all congenital cardiac malformations.[1]Traditional surgical repair on cardiopulmonary bypass produces s... To the Editor:Ventricular septal defect(VSD),as the most common congenital heart defect,accounts for up to 40%of all congenital cardiac malformations.[1]Traditional surgical repair on cardiopulmonary bypass produces substantial trauma and has a long recovery time,and percutaneous device closure is not suitable for all types of VSDs.As minimally invasive procedures have become more common in cardiac surgery,minimally invasive occluder device closure of VSDs under transesophageal echocardiography(TEE)guidance is widely used with excellent preliminary,midterm,and long-term results.[2-4]A small subxiphoid incision and the third/fourth left intercostal space beside the sternum are the two major incisions for device closure of VSDs.However,the differences between the two incisions are unknown.This report describes our experience with two incisions for device closure of VSDs. 展开更多
关键词 SEPTAL ECHOCARDIOGRAPHY ESOPHAGEAL
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