Objective:To study the effect of papaverine combined with tirofiban intracoronary injection on the degree of myocardial injury in patients with no reflow during percutaneous coronary intervention (PCI).Methods: Patien...Objective:To study the effect of papaverine combined with tirofiban intracoronary injection on the degree of myocardial injury in patients with no reflow during percutaneous coronary intervention (PCI).Methods: Patients who underwent PCI in Ankang Central Hospital between March 2014 and May 2017 were retrospectively studied and divided into two groups according to the intravascular drugs they received during PCI, combined group received papaverine combined with tirofiban intracoronary injection and control group received tirofiban intracoronary injection. The changes in myocardial injury indexes, platelet activation indexes and inflammatory molecules were measured before PCI as well as 24 h and 48 h after PCI.Results:Serum CK-MB, cTnI, MYO, IMA, CD62p, GPIIb/IIIa, MIP-1α, sICAM-1 and HMGB-1 levels as well as peripheral blood Lp-PLA2, PAF, P-selectin, ERK and NF-κB fluorescence intensity of both groups 24 h and 48 h after PCI were significantly lower than those before PCI, and serum CK-MB, cTnI, MYO, IMA, CD62p, GPIIb/IIIa, MIP-1α, sICAM-1 and HMGB-1 levels as well as peripheral blood Lp-PLA2, PAF, P-selectin, ERK and NF-κB fluorescence intensity of combined group 24 h and 48 h after PCI were significantly lower than those of control group.Conclusion: papaverine combined with tirofiban intracoronary injection for PCI can reduce the degree of myocardial injury.展开更多
Objective:To study the effect of serum miR-208 on platelet function, inflammatory response and myocardial injury in patients with acute myocardial infarction.Methods: Patients with acute myocardial infarction and thos...Objective:To study the effect of serum miR-208 on platelet function, inflammatory response and myocardial injury in patients with acute myocardial infarction.Methods: Patients with acute myocardial infarction and those with unstable angina pectoris who were treated in Ankang Central Hospital between June 2015 and October 2017 were selected as the AMI group and UAP group of the research respectively;the healthy volunteers who received physical examination in Ankang Central Hospital during the same period were selected as the control group. The miR-208 expression, platelet parameters, inflammatory response cytokines and myocardial injury markers were measured.Results: Serum miR-208 expression, PAF, TGF-β1, IL-10, TNF-α, sICAM1, sVCAM1, Myo, CK-MB, LDH and H-FABP contents as well as platelet surface C3aR, C5aR and GPIIb/IIIa expression intensity of AMI group and UAP group were significantly higher than those of control group, and serum miR-208 expression, PAF, TGF-β1, IL-10, TNF-α, sICAM1, sVCAM1, Myo, CK-MB, LDH and H-FABP contents as well as platelet surface C3aR, C5aR and GPIIb/IIIa expression intensity of AMI group were significantly higher than those of UAP group.Conclusion: The high expression of serum miR-208 can aggravate the platelet activation, inflammatory response activation and myocardial injury in patients with acute myocardial infarction.展开更多
文摘Objective:To study the effect of papaverine combined with tirofiban intracoronary injection on the degree of myocardial injury in patients with no reflow during percutaneous coronary intervention (PCI).Methods: Patients who underwent PCI in Ankang Central Hospital between March 2014 and May 2017 were retrospectively studied and divided into two groups according to the intravascular drugs they received during PCI, combined group received papaverine combined with tirofiban intracoronary injection and control group received tirofiban intracoronary injection. The changes in myocardial injury indexes, platelet activation indexes and inflammatory molecules were measured before PCI as well as 24 h and 48 h after PCI.Results:Serum CK-MB, cTnI, MYO, IMA, CD62p, GPIIb/IIIa, MIP-1α, sICAM-1 and HMGB-1 levels as well as peripheral blood Lp-PLA2, PAF, P-selectin, ERK and NF-κB fluorescence intensity of both groups 24 h and 48 h after PCI were significantly lower than those before PCI, and serum CK-MB, cTnI, MYO, IMA, CD62p, GPIIb/IIIa, MIP-1α, sICAM-1 and HMGB-1 levels as well as peripheral blood Lp-PLA2, PAF, P-selectin, ERK and NF-κB fluorescence intensity of combined group 24 h and 48 h after PCI were significantly lower than those of control group.Conclusion: papaverine combined with tirofiban intracoronary injection for PCI can reduce the degree of myocardial injury.
文摘Objective:To study the effect of serum miR-208 on platelet function, inflammatory response and myocardial injury in patients with acute myocardial infarction.Methods: Patients with acute myocardial infarction and those with unstable angina pectoris who were treated in Ankang Central Hospital between June 2015 and October 2017 were selected as the AMI group and UAP group of the research respectively;the healthy volunteers who received physical examination in Ankang Central Hospital during the same period were selected as the control group. The miR-208 expression, platelet parameters, inflammatory response cytokines and myocardial injury markers were measured.Results: Serum miR-208 expression, PAF, TGF-β1, IL-10, TNF-α, sICAM1, sVCAM1, Myo, CK-MB, LDH and H-FABP contents as well as platelet surface C3aR, C5aR and GPIIb/IIIa expression intensity of AMI group and UAP group were significantly higher than those of control group, and serum miR-208 expression, PAF, TGF-β1, IL-10, TNF-α, sICAM1, sVCAM1, Myo, CK-MB, LDH and H-FABP contents as well as platelet surface C3aR, C5aR and GPIIb/IIIa expression intensity of AMI group were significantly higher than those of UAP group.Conclusion: The high expression of serum miR-208 can aggravate the platelet activation, inflammatory response activation and myocardial injury in patients with acute myocardial infarction.
