An environmentally benign process was devel-oped for the transesterification of Jatropha curcas L. seed oil with methanol using artificial zeolites loaded with potassium acetate as a heterogeneous catalyst. After calc...An environmentally benign process was devel-oped for the transesterification of Jatropha curcas L. seed oil with methanol using artificial zeolites loaded with potassium acetate as a heterogeneous catalyst. After calcination for 5 h at 823 K, the catalyst loaded with 47 wt.% CH3COOK exhibited the highest efficiency and best catalytic activity. The easily prepared cata-lysts were characterized by means of X-ray dif-fraction and IR spectroscopy, as well as Hammett indicator titration. The results revealed a strong dependence of catalytic activity on ba-sicity. The optimum reaction conditions for transesterification of J. curcas oil were also in-vestigated. The methyl ester content in the bio-diesel product exceeded 91% after 4h reaction at reflux temperature in the presence of 2% solid catalyst and no water washing process is needed during workup.展开更多
A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cuc...A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cucumber mosaic virus(CMV) in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin(409.3 mg/m L).展开更多
A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activit...A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus(TMV) at 500 mg/m L. Among the target compounds,compound 7h showed the highest in vivo inactivation activity against TMV with the EC50 and EC90value of 45.6 and 327.5 mg/m L, respectively, which was similar to that of Ningnanmycin(46.9 and 329.4 mg/m L)and superior to that of Ribavirin(145.1 and 793.1 mg/m L). Meanwhile, the microscale thermophoresis and fluorescence spectroscopy experiments showed that the compound 7h had a strong interaction with the tobacco mosaic virus coat protein.展开更多
A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) were evaluated in viv...A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 30, 3s, 3w, and 3x exhibited excellent curative activity against CMV, with ECso values of 301.1 μg/mL, 315.7 μg/mL, 282.3 μg/mL, 230.5 μg/mL, respectively, which were better than that of Dufulin (373.7 μg/mL) and Ribavirin (726.3 μg/mL). In addition, the fluorescence spectroscopy experiment results showed that compound 3o showed strong combining capacity to tobacco mosaic virus coat orotein.展开更多
文摘An environmentally benign process was devel-oped for the transesterification of Jatropha curcas L. seed oil with methanol using artificial zeolites loaded with potassium acetate as a heterogeneous catalyst. After calcination for 5 h at 823 K, the catalyst loaded with 47 wt.% CH3COOK exhibited the highest efficiency and best catalytic activity. The easily prepared cata-lysts were characterized by means of X-ray dif-fraction and IR spectroscopy, as well as Hammett indicator titration. The results revealed a strong dependence of catalytic activity on ba-sicity. The optimum reaction conditions for transesterification of J. curcas oil were also in-vestigated. The methyl ester content in the bio-diesel product exceeded 91% after 4h reaction at reflux temperature in the presence of 2% solid catalyst and no water washing process is needed during workup.
基金assistance from the National Natural Science Foundation of China (No. 21302025)the Special Funds for Training object of Outstanding Young Scientific & Technological Talents in Guizhou Province (No. 2015-15#)the Science & Technology Foundation of Guizhou Province (No. J[2014]2056#)
文摘A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cucumber mosaic virus(CMV) in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin(409.3 mg/m L).
基金supported by the National Natural Science Foundation of China(Nos.21362004,21562013)Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China(20154004)
文摘A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus(TMV) at 500 mg/m L. Among the target compounds,compound 7h showed the highest in vivo inactivation activity against TMV with the EC50 and EC90value of 45.6 and 327.5 mg/m L, respectively, which was similar to that of Ningnanmycin(46.9 and 329.4 mg/m L)and superior to that of Ribavirin(145.1 and 793.1 mg/m L). Meanwhile, the microscale thermophoresis and fluorescence spectroscopy experiments showed that the compound 7h had a strong interaction with the tobacco mosaic virus coat protein.
基金supported by the National Natural Science Foundation of China(Nos. 21562013 and 21362004)Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China(No. 20154004)+1 种基金the Provincial University Cooperation Plan of Guizhou Province in China(No. 20147001)Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan
文摘A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 30, 3s, 3w, and 3x exhibited excellent curative activity against CMV, with ECso values of 301.1 μg/mL, 315.7 μg/mL, 282.3 μg/mL, 230.5 μg/mL, respectively, which were better than that of Dufulin (373.7 μg/mL) and Ribavirin (726.3 μg/mL). In addition, the fluorescence spectroscopy experiment results showed that compound 3o showed strong combining capacity to tobacco mosaic virus coat orotein.